Apoptosis as a Therapeutic Target in Chronic Lymphocytic Leukemia

2015 ◽  
Vol 5 ◽  
pp. 11-15 ◽  
Author(s):  
Christian Billard
2013 ◽  
Vol 13 (23) ◽  
pp. 2955-2964 ◽  
Author(s):  
Tiziana Vaisitti ◽  
Valentina Audrito ◽  
Sara Serra ◽  
Cinzia Bologna ◽  
Francesca Arruga ◽  
...  

2008 ◽  
Vol 14 (12) ◽  
pp. 3984-3992 ◽  
Author(s):  
Elaine Willmore ◽  
Sarah L. Elliott ◽  
Tryfonia Mainou-Fowler ◽  
Geoffrey P. Summerfield ◽  
Graham H. Jackson ◽  
...  

2012 ◽  
Vol 103 (12) ◽  
pp. 2056-2063 ◽  
Author(s):  
Ling Liu ◽  
Lei Fan ◽  
Cheng Fang ◽  
Zhi-Jian Zou ◽  
Shu Yang ◽  
...  

Leukemia ◽  
2012 ◽  
Vol 27 (5) ◽  
pp. 1090-1099 ◽  
Author(s):  
D E Spaner ◽  
E Lee ◽  
Y Shi ◽  
F Wen ◽  
Y Li ◽  
...  

Author(s):  
Hadeer A. Abbassy ◽  
Reham A. Aboelwafa ◽  
Omar M. Ghallab

Background: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that has a highly variable clinical course. Genomic features as zeta-chain-associated protein kinase 70 (ZAP70) expression and CD38 expression provide further differentiation of disease prognosis. Extensive studies have confirmed the oncogenic activities of IL-9 in lymphoma. The aim of the current study was to investigate the contribution of IL-9 expression to the pathogenesis of CLL and its correlation to other prognostic parameters.Methods: This study was conducted on 80 patients at diagnosis with CLL and 80 healthy controls. Using real time polymerase chain reaction and enzyme linked immunosorbant assay, IL-9 mRNA expression and its serum level were compared between patients and controls. They were both correlated with other prognostic factors.Results: There was an overexpression of IL-9 in CLL patients that correlated with modified Rai staging, ZAP70, CD38 and all hallmarks of an active and aggressive disease. The correlation between IL-9 upregulation and patient characteristics provided a direct clinical evidence for its contribution to the pathogenesis of CLL.Conclusions: Significantly higher expression of IL -9 measured at both the mRNA and the protein levels in patients with CLL that correlates with more complex course of the disease and worse prognosis may allow one to speculate its importance in the pathogenesis of the disease and its possible role as a potential therapeutic target.


2013 ◽  
Vol 93 (3) ◽  
pp. 425-435 ◽  
Author(s):  
Huayuan Zhu ◽  
Wei Wu ◽  
Yuan Fu ◽  
Wenyi Shen ◽  
Kourong Miao ◽  
...  

2019 ◽  
Vol 10 (1) ◽  
pp. 23
Author(s):  
MohamedMahmoud El-Khawanky ◽  
MohamedHanfy Morsy ◽  
AminaMohamed Elnaggar ◽  
OlaAli Hussin ◽  
MohgaMahmoud Zaewer ◽  
...  

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