scholarly journals The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer

2019 ◽  
Vol 51 (4) ◽  
pp. 1411-1419 ◽  
Author(s):  
Se-Il Go ◽  
Gyung Hyuck Ko ◽  
Won Sup Lee ◽  
Jeong-Hee Lee ◽  
Sang-Ho Jeong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Ki 67 ◽  
Cd44 Variant ◽  
Single Use ◽  
Better Than

A deep neural network improves endoscopic detection of early gastric cancer without blind spots

Endoscopy ◽  
2019 ◽  
Vol 51 (06) ◽  
pp. 522-531 ◽  
Author(s):  
Lianlian Wu ◽  
Wei Zhou ◽  
Xinyue Wan ◽  
Jun Zhang ◽  
Lei Shen ◽  
...  
Keyword(s):  
Neural Network ◽  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Predictive Value ◽  
The Third ◽  
Visual Tasks ◽  
Deep Convolution Neural Network ◽  
Different Parts ◽  
Better Than ◽  
Blind Spots

Abstract Background Gastric cancer is the third most lethal malignancy worldwide. A novel deep convolution neural network (DCNN) to perform visual tasks has been recently developed. The aim of this study was to build a system using the DCNN to detect early gastric cancer (EGC) without blind spots during esophagogastroduodenoscopy (EGD). Methods 3170 gastric cancer and 5981 benign images were collected to train the DCNN to detect EGC. A total of 24549 images from different parts of stomach were collected to train the DCNN to monitor blind spots. Class activation maps were developed to automatically cover suspicious cancerous regions. A grid model for the stomach was used to indicate the existence of blind spots in unprocessed EGD videos. Results The DCNN identified EGC from non-malignancy with an accuracy of 92.5 %, a sensitivity of 94.0 %, a specificity of 91.0 %, a positive predictive value of 91.3 %, and a negative predictive value of 93.8 %, outperforming all levels of endoscopists. In the task of classifying gastric locations into 10 or 26 parts, the DCNN achieved an accuracy of 90 % or 65.9 %, on a par with the performance of experts. In real-time unprocessed EGD videos, the DCNN achieved automated performance for detecting EGC and monitoring blind spots. Conclusions We developed a system based on a DCNN to accurately detect EGC and recognize gastric locations better than endoscopists, and proactively track suspicious cancerous lesions and monitor blind spots during EGD.

Abstract 4930: Ki-67 serves as a prognostic marker in early gastric cancer, but not in advanced gastric cancer

2016 ◽  
Author(s):  
Won Sup Lee ◽  
Gyung Hyuck Ko ◽  
Se-Il Go ◽  
Jeong-Hee Lee ◽  
Sang-Ho Jeong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Prognostic Marker ◽  
Ki 67

The significance of p53 and Ki-67 expression rate in adenoma and adenocarcinoma of the stomach.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 32-32
Author(s):  
I. Baek
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Tumor Tissue ◽  
Subtotal Gastrectomy ◽  
Tissue Expression ◽  
Endoscopic Biopsy ◽  
Low Grade ◽  
Gastric Adenoma ◽  
Ki 67 ◽  
Low Grade Dysplasia

32 Background: Endoscopic submucosal dissection (ESD) is used for the treatment of gastric adenoma as well as early gastric cancer. Gastric adenoma is a well-known precursor of gastric cancer. The aim of this study is to investigate the expression degree of p53 and Ki-67 in gastric adenoma can predict progression to gastric cancer. Methods: We analyzed p53 and Ki-67 expression degree in the tumor tissue of 16 gastric adenoma patients treated by ESD and 11 early gastric cancer patients treated by subtotal gastrectomy at Kangnam Sacred Heart Hospital of Hallym University between November 2008 and May 2009. According to the fraction of stained nuclei in tumor tissue, expression degree was classified as < 10% = negative, 10%∼33% = 1+, 34%∼66% = 2+, > 66% = 3+. Results: Mean age was 65.1 ± 11.5 years and mean tumor size was 33.7 ± 20.2mm. Among 16 gastric adenoma patients, low-grade dysplasia were 11 and high grade dysplasia were 5. p53 positivity was not different between gastric adenoma and gastric cancer, but Ki-67 positivity was significantly different between adenoma and cancer (p < 0.05). In addition, Ki-67 positivity was increasing tendency as the pathology progress from low grade dysplasia to cancer. Conclusions: Ki-67 positivity grade seems to be correlated with malignancy. High Ki-67 positivity in gastric adenoma can predict progression to gastric cancer. Even if endoscopic biopsy showed low grade dysplasia, additional ESD should be preferentially considered in lesions with high Ki-67 positivity. No significant financial relationships to disclose.

Laparoscopy-Assisted Pylorus-Preserving Gastrectomy Is Better Than Laparoscopy-Assisted Distal Gastrectomy for Middle-Third Early Gastric Cancer

2014 ◽  
Vol 259 (3) ◽  
pp. 485-493 ◽  
Author(s):  
Yun-Suhk Suh ◽  
Dong-Seok Han ◽  
Seong-Ho Kong ◽  
Sebastianus Kwon ◽  
Cheong-Il Shin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Distal Gastrectomy ◽  
Better Than

scholarly journals Clinical and Histopathological Features of Early Gastric Cancer With Unclear Lateral Demarcation

2021 ◽  
Author(s):  
Kengo Nagai ◽  
Yoshito Hayashi ◽  
Ryotaro Uema ◽  
Takanori Inoue ◽  
Keiichi Kimura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Narrow Band Imaging ◽  
Ki 67 ◽  
Histopathological Features ◽  
Gastric Cancers ◽  
Antibody Staining ◽  
Gastric Phenotype ◽  
History Of ◽  
Superficial Epithelium

Abstract Background Magnifying-endoscopy with narrow band imaging (M-NBI) is useful to determine lateral demarcation of early gastric cancers, but determining the lateral demarcation is sometimes difficult. Features related to the unclear lateral demarcation remain unknown. We evaluated the clinical and histopathological features of early gastric cancers with unclear lateral demarcation by M-NBI. Methods This single-center retrospective cohort study analyzed early gastric cancer treated by endoscopic submucosal dissection (ESD) from January 2013 to August 2015. We evaluated clinicopathological and immunohistochemical features using anti-p53, -Ki-67, -MUC5AC, -MUC6, -MUC2, and -CD10 antibody staining. We compared the lateral demarcation between the demarcation clear (DC) and demarcation unclear (DU) lesions by using M-NBI. Results A total of 224 differentiated adenocarcinomas (DU group: 18 lesions; DC group: 206 lesions) were analyzed. The history of successful Helicobacter pylori eradication was significantly more frequent in the DU group (p = 0.001). We examined tissues of 72 lesions immunohistochemically, including 18 lesions in the DU group and 54 randomly selected lesions in the DC group. Non-neoplastic superficial epithelium is more frequently observed in the DU group (p = 0.0058). Additionally, the DU group showed a significantly higher expression of gastric phenotype marker (p = 0.023), lower p53 score (p = 0.0002), and lower Ki-67 labeling index (p = 0.0293). The non-neoplastic superficial epithelium and low p53 score were significant independent variables associated with unclear lateral demarcation by M-NBI in the multivariate analysis. Conclusions Non-neoplastic superficial epithelium and low p53 score were associated with the difficultly in determining lateral demarcation in early gastric cancers by M-NBI.

scholarly journals CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer

2016 ◽  
Vol 48 (1) ◽  
pp. 142-152 ◽  
Author(s):  
Se-Il Go ◽  
Gyung Hyuck Ko ◽  
Won Sup Lee ◽  
Rock Bum Kim ◽  
Jeong-Hee Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Prognostic Marker ◽  
Cd44 Variant

scholarly journals CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence

2013 ◽  
Vol 109 (2) ◽  
pp. 379-386 ◽  
Author(s):  
K Hirata ◽  
H Suzuki ◽  
H Imaeda ◽  
J Matsuzaki ◽  
H Tsugawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Predictive Marker ◽  
Cd44 Variant

scholarly journals CHARACTERIZATION OF THE MUCIN PHENOTYPE CAN PREDICT GASTRIC CANCER RECURRENCE AFTER ENDOSCOPIC MUCOSAL RESECTION

2017 ◽  
Vol 54 (4) ◽  
pp. 308-314 ◽  
Author(s):  
Fabio Yuji HONDO ◽  
Humberto KISHI ◽  
Adriana Vaz SAFATLE-RIBEIRO ◽  
Fernanda Cristina Simões PESSORRUSSO ◽  
Ulysses RIBEIRO JR ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Local Recurrence ◽  
Endoscopic Mucosal Resection ◽  
Gastric Adenocarcinoma ◽  
Biological Behavior ◽  
Ki 67 ◽  
Mucin Phenotype ◽  
Mucosal Resection ◽  
Mixed Phenotype

ABSTRACT BACKGROUND: Endoscopic mucosal resection is still considered an accepted treatment for early gastric cancer for selected cases. Histopathologic criteria for curative endoscopic resection are intramucosal well-differentiated adenocarcinoma, lateral and deep margins free of tumor, no histological ulceration, and no venous or lymphatic embolism. A 5% local recurrence rate has been described even when all the above-mentioned criteria are met. On the other hand, antigen expression by tumoral cells has been related to the biological behavior of several tumors. OBJECTIVE: To evaluate whether early gastric cancer mucin immunoexpression, p53 and Ki-67, can predict recurrence after endoscopic mucosal resection, even when standard histopathologic criteria for curative measures have been attempted. METHODS: Twenty-two patients with early gastric cancer were considered to have been completely resected by endoscopic mucosal resection. Local recurrence occurred in 5/22 (22.7%). Immunohistochemical study was possible in 18 (81.8%) resected specimens. Patients were divided in two groups: those with and those without local recurrence. They were compared across demographic, endoscopic, histologic data, and immunohistochemical factors for MUC2, MUC5a, CD10, p53, and Ki-67. RESULTS: Mucin immunoexpression allowed a reclassification of gastric adenocarcinoma in intestinal (10), gastric (2), mixed (4), and null phenotypes (2). Mixed phenotype (positive for both MUC2 and MUC5a) was found in 80% of cases in the local recurrence group, while the intestinal type (positive MUC2 and negative MUC5a) was found in 76.9% of cases without local recurrence (P=0.004). Other observed features did not correlate with neoplastic recurrence. CONCLUSION: The mixed phenotype of early gastric adenocarcinoma is associated with a higher probability of local recurrence after endoscopic mucosal resection.

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