scholarly journals Interleukin-6/signal transducer and activator of transcription 3 promotes prostate cancer resistance to androgen deprivation therapy via regulating pituitary tumor transforming gene 1 expression

2018 ◽  
Vol 109 (3) ◽  
pp. 678-687 ◽  
Author(s):  
Shengquan Huang ◽  
Qian Liu ◽  
Qianjin Liao ◽  
Qingjian Wu ◽  
Bishao Sun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Interleukin 6 ◽  
Pituitary Tumor ◽  
Androgen Deprivation ◽  
Signal Transducer ◽  
Cancer Resistance ◽  
Pituitary Tumor Transforming Gene ◽  
Transcription 3 ◽  
Transforming Gene

Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13

Tumor Biology ◽  
2015 ◽  
Vol 37 (12) ◽  
pp. 15495-15500 ◽  
Author(s):  
Yun-Hua Lin ◽  
Yong Tian ◽  
Jun-Sheng Wang ◽  
Yong-Guang Jiang ◽  
Yong Luo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Pituitary Tumor ◽  
Prostate Cancer Cells ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene

Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy

The Prostate ◽  
2011 ◽  
Vol 72 (11) ◽  
pp. 1207-1213 ◽  
Author(s):  
Shuichi Komatsu ◽  
Noboru Hara ◽  
Fumio Ishizaki ◽  
Tsutomu Nishiyama ◽  
Itsuhiro Takizawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lipid Metabolism ◽  
Androgen Deprivation Therapy ◽  
Sex Steroids ◽  
Interleukin 6 ◽  
Androgen Deprivation ◽  
Lipid Metabolism Disorder ◽  
Metabolism Disorder

Expression of androgen receptor, somatostatin receptor subtypes, aurora kinase A, and interleukin-6 in prostate cancer before androgen ablation.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16508-e16508
Author(s):  
Angela Gernone ◽  
Senia Trabucco ◽  
Eliano Cascardi ◽  
Leonardo Resta ◽  
Franco Silvestris ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Interleukin 6 ◽  
Somatostatin Receptor ◽  
Aurora Kinase ◽  
Androgen Deprivation ◽  
Aurora Kinase A ◽  
Androgen Ablation ◽  
Visceral Metastases ◽  
Kinase A

e16508 Background: Neuroendocrine differentiation (NED) in prostate cancer (PC) can be detected by immunohistochemistry as single cells in conventional adenocarcinoma. NEPC is a poor-recognized late presentation of hormone refractory subtype of PC AR-negative. NEPC correlates with poor prognosis, tumor progression during androgen-deprivation therapy and frequent visceral metastases. Aurora kinase A (AURKA) and Interleukin-6 (IL-6) cooperate to induce NED. The aim of this study was to correlate the expression of somatostatin receptor (SSTR) 1- 2- 3- 4- 5 subtypes, AURKA and IL-6 in primary PC with NED pattern before androgen ablation and OS. Methods: PC tissues were reviewed from 60 pts who had undergone biopsy or radical prostatectomy for previously untreated advanced or metastatic PC from 2010 to 2016. 10 samples expressed histologically chromogranin A (CgA), a marker of NED expression. Median age was 67 years (47-80), Gleason score ≥ 7, median PSA was 60 ng/ml (1.3-1000), ECOG 0/1 and bone-visceral sites measurable in 90% of cases. For comparison purposes, 8 pathology specimens from pts with primary PC negative for CgA expression were used. Results: SSTR1-2-4-5 were detected only in the nucleus of PC cells in 10/10 samples. AR was expressed in all 10 samples CgA positive. SSTR3 and AURKA were not expressed in all 10 samples. IL-6 was detected in 9/10 samples. All 10 pts developed early onset of CRPC, more aggressive clinical course with rapid occurrence of visceral metastases and OS was < 12 mos. Conclusions: In metastatic prostate cancer, pretreatment NED pattern can be a predictor for progression and survival after hormonal and during standard chemotherapy. Most likely NEPC become AR negative during disease progression and in response to androgen deprivation therapy. We supposed, according to other data, that the novel potent AR-targeted drugs should be not used in this subset of patients. SSTRs and somatostatin analogs are not potential targets for prostate cancer.

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