Ultrasound-triggered liposomes for on-demand local anesthesia

2018 ◽  
Vol 9 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Kathleen Cullion ◽  
Alina Y Rwei ◽  
Daniel S Kohane
Keyword(s):  
Local Anesthesia ◽  
On Demand

scholarly journals Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Zhang ◽  
Tianjiao Ji ◽  
Yang Li ◽  
Yueqin Zheng ◽  
Manisha Mehta ◽  
...  
Keyword(s):  
Local Anesthesia ◽  
Local Anesthetics ◽  
Triggered Release ◽  
On Demand ◽  
Macromolecular Prodrug

Near-infrared triggered on-demand local anesthesia using a jammed microgels system

2020 ◽  
Vol 31 (17) ◽  
pp. 2252-2267
Author(s):  
Qiying Pang ◽  
Jia Zhao ◽  
Shuchi Zhang ◽  
Xiaoqing Zhang
Keyword(s):  
Local Anesthesia ◽  
Near Infrared ◽  
On Demand

scholarly journals Multiply repeatable and adjustable on-demand phototriggered local anesthesia

2017 ◽  
Vol 251 ◽  
pp. 68-74 ◽  
Author(s):  
Alina Y. Rwei ◽  
Changyou Zhan ◽  
Bruce Wang ◽  
Daniel S. Kohane
Keyword(s):  
Local Anesthesia ◽  
On Demand

scholarly journals Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes

2015 ◽  
Vol 112 (51) ◽  
pp. 15719-15724 ◽  
Author(s):  
Alina Y. Rwei ◽  
Jung-Jae Lee ◽  
Changyou Zhan ◽  
Qian Liu ◽  
Meryem T. Ok ◽  
...  
Keyword(s):  
Cell Culture ◽  
Sciatic Nerve ◽  
Local Anesthesia ◽  
Nerve Block ◽  
Near Infrared ◽  
Tissue Reaction ◽  
On Demand ◽  
Nir Light

Pain management would be greatly enhanced by a formulation that would provide local anesthesia at the time desired by patients and with the desired intensity and duration. To this end, we have developed near-infrared (NIR) light-triggered liposomes to provide on-demand adjustable local anesthesia. The liposomes contained tetrodotoxin (TTX), which has ultrapotent local anesthetic properties. They were made photo-labile by encapsulation of a NIR-triggerable photosensitizer; irradiation at 730 nm led to peroxidation of liposomal lipids, allowing drug release. In vitro, 5.6% of TTX was released upon NIR irradiation, which could be repeated a second time. The formulations were not cytotoxic in cell culture. In vivo, injection of liposomes containing TTX and the photosensitizer caused an initial nerve block lasting 13.5 ± 3.1 h. Additional periods of nerve block could be induced by irradiation at 730 nm. The timing, intensity, and duration of nerve blockade could be controlled by adjusting the timing, irradiance, and duration of irradiation. Tissue reaction to this formulation and the associated irradiation was benign.

Mental imagery and intraoral local anesthesia

1984 ◽  
Vol 48 (12) ◽  
pp. 653-658
Author(s):  
MM Walsh ◽  
R Hannebrink ◽  
B Heckman
Keyword(s):  
Local Anesthesia ◽  
Mental Imagery

1117: Percutaneous CT-Guided Renal Cryoablation Under Local Anesthesia: Pain Assessment

2006 ◽  
Vol 175 (4S) ◽  
pp. 359-359
Author(s):  
Sompol Permpongkoso ◽  
Aaron Sulman ◽  
Stephen B. Solomon ◽  
GaryX Gong ◽  
Louis R. Kavoussi
Keyword(s):  
Local Anesthesia ◽  
Pain Assessment ◽  
Ct Guided
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