scholarly journals Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Zhang ◽  
Tianjiao Ji ◽  
Yang Li ◽  
Yueqin Zheng ◽  
Manisha Mehta ◽  
...  
2016 ◽  
Vol 4 (1) ◽  
pp. 17
Author(s):  
Rodica Sîrbu ◽  
Emin Cadar ◽  
Cezar Laurențiu Tomescu ◽  
Cristina Luiza Erimia ◽  
Stelian Paris ◽  
...  

Local anesthetics are substances which, by local action groups on the runners, cause loss of reversible a painful sensation, delimited corresponding to the application. They allow small surgery, short in duration and the endoscopic maneuvers. May be useful in soothe teething pain of short duration and in the locking of the nervous disorders in medical care. Local anesthesia is a process useful for the carrying out of surgery and of endoscopic maneuvers, to soothe teething pain in certain conditions, for depriving the temporary structures peripheral nervous control. Reversible locking of the transmission nociceptive, the set of the vegetative and with a local anesthetic at the level of the innervations peripheral nerve, roots and runners, a trunk nervous, around the components of a ganglion or coolant is cefalorahidian practice anesthesia loco-regional. Local anesthetics summary and semi-summary have multiple applications in dentistry, consulting, surgery and obstetrics, constituting "weapons" very useful in the fight against the pain.


2018 ◽  
Vol 9 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Kathleen Cullion ◽  
Alina Y Rwei ◽  
Daniel S Kohane
Keyword(s):  

2021 ◽  
pp. 22-22
Author(s):  
Rasa Mladenovic

Clinicians should identify the risks associated with the use of anesthetics and understand the maximum recommended doses of local anesthetics. Errors in calculating the dose of local anesthetics are common due to the widespread use of these agents. Different methods of calculating the dose of the drug have different advantages and disadvantages, and no method can guarantee a calculation without errors. Nomogram is a simple graphical tool on which one can read the result of arithmetic operations with given numbers. The nomogram for calculating the maximum dose of local anesthetic enables quick cross-checking of the calculation, based on the patient's age or body weight. They are of special importance in the application of local anesthesia in children.


Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3051-3057 ◽  
Author(s):  
Tae-Hong Park ◽  
Thomas W. Eyster ◽  
Joshua M. Lumley ◽  
Sangyeul Hwang ◽  
Kyung Jin Lee ◽  
...  
Keyword(s):  

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 528 ◽  
Author(s):  
Ju Hyang Park ◽  
Da In Kim ◽  
Sang Gi Hong ◽  
Hojun Seo ◽  
Jongbok Kim ◽  
...  

A new system for the easy loading and NIR light-triggered release of drugs is introduced. It consists of poly(ε-caprolactone) (PCL) hollow nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings, which can enhance the connectivity between the interior and the exterior, enable the easy loading of drug molecules into the interior voids, and their successive sealing ensures a stable encapsulation of the drug. Upon exposure to an external NIR light irradiation, the photothermal agent generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, leading to the formation of nanopores on their shells, and consequently, the instant release of the encapsulated drug molecules through the pores. The synergistic activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy.


2020 ◽  
Vol 31 (17) ◽  
pp. 2252-2267
Author(s):  
Qiying Pang ◽  
Jia Zhao ◽  
Shuchi Zhang ◽  
Xiaoqing Zhang

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