Near-infrared triggered on-demand local anesthesia using a jammed microgels system

Pain management would be greatly enhanced by a formulation that would provide local anesthesia at the time desired by patients and with the desired intensity and duration. To this end, we have developed near-infrared (NIR) light-triggered liposomes to provide on-demand adjustable local anesthesia. The liposomes contained tetrodotoxin (TTX), which has ultrapotent local anesthetic properties. They were made photo-labile by encapsulation of a NIR-triggerable photosensitizer; irradiation at 730 nm led to peroxidation of liposomal lipids, allowing drug release. In vitro, 5.6% of TTX was released upon NIR irradiation, which could be repeated a second time. The formulations were not cytotoxic in cell culture. In vivo, injection of liposomes containing TTX and the photosensitizer caused an initial nerve block lasting 13.5 ± 3.1 h. Additional periods of nerve block could be induced by irradiation at 730 nm. The timing, intensity, and duration of nerve blockade could be controlled by adjusting the timing, irradiance, and duration of irradiation. Tissue reaction to this formulation and the associated irradiation was benign.

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Ultrasound-triggered liposomes for on-demand local anesthesia

Therapeutic Delivery ◽

10.4155/tde-2017-0100 ◽

2018 ◽

Vol 9 (1) ◽

pp. 5-8 ◽

Cited By ~ 5

Author(s):

Kathleen Cullion ◽

Alina Y Rwei ◽

Daniel S Kohane

Keyword(s):

Local Anesthesia ◽

On Demand

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An All-in-one Nanoplatform with Near-infrared Light Promoted On-demand Oxygen Release and Deep Intratumoral Penetration for Synergistic Photothermal/Photodynamic Therapy

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2021.10.082 ◽

2021 ◽

Author(s):

Xiangmei Liu ◽

Ruhua Li ◽

Yanli Zhou ◽

Wen Lv ◽

Shujuan Liu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Near Infrared ◽

Infrared Light ◽

Oxygen Release ◽

Near Infrared Light ◽

On Demand

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Photophysics and photochemistry of NIR absorbers derived from cyanines: key to new technologies based on chemistry 4.0

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.16.40 ◽

2020 ◽

Vol 16 ◽

pp. 415-444 ◽

Cited By ~ 7

Author(s):

Bernd Strehmel ◽

Christian Schmitz ◽

Ceren Kütahya ◽

Yulian Pang ◽

Anke Drewitz ◽

...

Keyword(s):

Electrochemical Properties ◽

High Power ◽

Near Infrared ◽

New Technologies ◽

Light Sources ◽

Hydrophobic Properties ◽

On Demand ◽

Nir Light ◽

Photothermal Treatment ◽

End Groups

Cyanines derived from heptamethines were mainly discussed regarding their functionalization to broaden the solubility in different surroundings exhibiting either hydrophilic or hydrophobic properties and to tailor made the ΔG et photopysical properties with respect to absorption and fluorescence. Electrochemical properties were additionally considered for some selected examples. The cyanines chosen comprised as end groups either indolenine, benzo[e]- or benzo[cd]indolium pattern, which facilitated to shift the absorption between 750–1000 nm. This enabled their use in applications with light sources emitting in the near-infrared (NIR) region selected from high power LEDs or lasers with line-shaped focus. The absorbers considered were discussed regarding their function as sensitizer for applications related to Chemistry 4.0 standards. These were mainly photopolymer coatings, which can be found for applications in the graphic industry or to protect selected substrates. The huge release of heat on demand upon turning ON or OFF the NIR light source enables them for photothermal treatment in processes requesting heat to initiate either chemical (activated reactions) or physical (melting, evaporation) events.

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Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

Chemical Science ◽

10.1039/c8sc04854a ◽

2019 ◽

Vol 10 (9) ◽

pp. 2785-2790 ◽

Cited By ~ 37

Author(s):

Rongchen Wang ◽

Kaikai Dong ◽

Ge Xu ◽

Ben Shi ◽

Tianli Zhu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Near Infrared ◽

Anticancer Therapy ◽

Infrared Emission ◽

Normal Tissues ◽

On Demand ◽

Near Infrared Emission

A theranostic platform enables the selective visualization of H2S-rich cancers and imaging-directed on-demand photodynamic therapy of the detected cancers while leaving normal tissues untouched.

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