Is Pseudo-Cushing's Syndrome in a Critically Ill Patient "Pseudo"? Hypothesis and Supportive Case Report

2007 ◽  
Vol 13 (2) ◽  
pp. 153-158 ◽  
Author(s):  
David Kem ◽  
Jordan Metcalf ◽  
Ana Cornea ◽  
Monica Dunnam ◽  
Alice Engelbrecht ◽  
...  
Author(s):  
Carlos Rubiano ◽  
Kathleen Tompkins ◽  
Subhashini A Sellers ◽  
Brian Bramson ◽  
Joseph Eron ◽  
...  

Abstract We present a case of a critically ill patient with COVID-19 found to have AIDS and Pneumocystis jirovecii pneumonia (PCP). COVID-19 and PCP co-occurrence is increasingly reported and may complicate diagnostic and therapeutic strategies. Patients with severe COVID-19 should be screened for underlying immunocompromise and coinfections should be considered.


2021 ◽  
pp. 194187442110043
Author(s):  
Henly Hewan ◽  
Annie Yang ◽  
Aparna Vaddiparti ◽  
Benison Keung

In late 2019, the novel coronavirus, SARS-CoV-2, and the disease it causes, COVID-19, was identified. Since then many different neurological manifestations of COVID-19 have been well reported. Movement abnormalities have been rarely described. We report here a critically ill patient with COVID-19 who developed generalized myoclonus during the recovery phase of the infection. Myoclonus was associated with cyclical fevers and decreased alertness. Movements were refractory to conventional anti-epileptic therapies. There was concern that myoclonus could be part of a post-infectious immune-mediated syndrome. The patient improved fully with a 4-day course of high-dose steroids. Our experience highlights a rare, generalized myoclonus syndrome associated with COVID-19 that may be immune-mediated and is responsive to treatment.


2019 ◽  
Vol 66 (2) ◽  
pp. 175-180
Author(s):  
Kewei Wang ◽  
Fuqiang Liu ◽  
Chuanlong Wu ◽  
Yan Liu ◽  
Lin Qi ◽  
...  

1970 ◽  
Vol 22 (1) ◽  
pp. 142-143
Author(s):  
M Nowshad Ali ◽  
S Hoq Miah ◽  
M Meharunnesa ◽  
SM Badruddoza ◽  
Mushtaque Ahmed

Adrenocortical carcinoma is an uncommon tumour in the pediatric population. Account for only a small fraction of pediatric adrenal tumour. Most tumors in children are functional, and virilization is by far the most common presenting symptom, followed by Cushing's syndrome and precocious puberty. All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. DOI: 10.3329/taj.v22i1.5039 TAJ 2009; 22(1): 142-143


2012 ◽  
Vol 2 (2) ◽  
pp. 208-210
Author(s):  
Said Azzoug ◽  
◽  
Aicha Maiz Hadj Ahmed ◽  
Farida Chentli

Le syndrome de cushing (SC) est rare durant la grossesse et ses conséquences maternofœtales Peuvent être fatales. Nous rapportons l’observation d’une patiente qui présentait un SC compliqué d’un HELLP syndrome. Observation : Une patiente âgée de 35 ans consulte à 26 semaines d’aménorrhée (SA) pour prise en charge d’un SC. Sur le plan clinique elle présente une obésité faciotronculaire et des signes d’hypercatabolisme. Le cycle du cortisol était rompu, le freinage faible était négatif et le taux d’ACTH était inférieur à 1 pg/ml. L’IRM abdominale objectivait une masse surrénalienne droite de 35 mm. L’hypercorticisme s’est compliqué de pré-éclampsie, de diabète sucré et d’hypokaliémie. L’évolution était marquée par une élévation des ALAT, une thrombopénie et une anémie compatibles avec un HELLP syndrome obligeant la réalisation d’une césarienne de sauvetage à 29 SA avec naissance d’un nouveau-né de sexe masculin vivant et sain. La patiente a bénéficié par la suite d’une surrénalectomie droite et l’étude histologique concluait à un adénome. Conclusion : Le SC de la grossesse est une pathologie rare dont l’étiologie est le plus souvent surrénalienne. Le pronostic materno-fœtal est engagé du fait d’une forte prévalence de complications pouvant engager le pronostic vital tel que le HELLP syndrome qui représente une urgence obstétricale


Author(s):  
Ziadoon Faisal ◽  
Miguel Debono

Summary In this case report, we describe the management of a patient who was admitted with an ectopic ACTH syndrome during the COVID pandemic with new-onset type 2 diabetes, neutrophilia and unexplained hypokalaemia. These three findings when combined should alert physicians to the potential presence of Cushing’s syndrome (CS). On admission, a quick diagnosis of CS was made based on clinical and biochemical features and the patient was treated urgently using high dose oral metyrapone thus allowing delays in surgery and rapidly improving the patient’s clinical condition. This resulted in the treatment of hyperglycaemia, hypokalaemia and hypertension reducing cardiovascular risk and likely risk for infection. Observing COVID-19 pandemic international guidelines to treat patients with CS has shown to be effective and offers endocrinologists an option to manage these patients adequately in difficult times. Learning points This case report highlights the importance of having a low threshold for suspicion and investigation for Cushing’s syndrome in a patient with neutrophilia and hypokalaemia, recently diagnosed with type 2 diabetes especially in someone with catabolic features of the disease irrespective of losing weight. It also supports the use of alternative methods of approaching the diagnosis and treatment of Cushing’s syndrome during a pandemic as indicated by international protocols designed specifically for managing this condition during Covid-19.


Endocrine ◽  
2010 ◽  
Vol 38 (3) ◽  
pp. 328-334 ◽  
Author(s):  
Therdpong Tempark ◽  
Voraluk Phatarakijnirund ◽  
Susheera Chatproedprai ◽  
Suttipong Watcharasindhu ◽  
Vichit Supornsilchai ◽  
...  

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