scholarly journals ACROMEGALY OCCURRING IN A PATIENT WITH A PITUITARY ADENOMA, LYMPHOCYTIC HYPOPHYSITIS, AND A RATHKE CLEFT CYST

2017 ◽  
Vol 3 (2) ◽  
pp. e121-e125
Author(s):  
Anupa Sharma ◽  
Eric K.Richfield ◽  
Sara E. Lubitz
Keyword(s):  
Pituitary Adenoma ◽  
Lymphocytic Hypophysitis ◽  
Rathke Cleft Cyst

scholarly journals Differentiation of Pituitary Adenoma from Rathke Cleft Cyst: Combining MR Image Features with Texture Features

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Yang Zhang ◽  
Chaoyue Chen ◽  
Zerong Tian ◽  
Yangfan Cheng ◽  
Jianguo Xu
Keyword(s):  
Pituitary Adenoma ◽  
Signal Intensity ◽  
Texture Features ◽  
Binary Logistic Regression ◽  
Image Features ◽  
Image Feature ◽  
Binary Logistic Regression Analysis ◽  
Mr Image ◽  
Rathke Cleft Cyst ◽  
Contrast Enhanced

Objectives. To differentiate pituitary adenoma from Rathke cleft cyst in magnetic resonance (MR) scan by combing MR image features with texture features. Methods. A total number of 133 patients were included in this study, 83 with pituitary adenoma and 50 with Rathke cleft cyst. Qualitative MR image features and quantitative texture features were evaluated by using the chi-square tests or Mann–Whitney U test. Binary logistic regression analysis was conducted to investigate their ability as independent predictors. ROC analysis was conducted subsequently on the independent predictors to assess their practical value in discrimination and was used to investigate the association between two types of features. Results. Signal intensity on the contrast-enhanced image was found to be the only significantly different MR image feature between the two lesions. Two texture features from the contrast-enhanced images (Histo-Skewness and GLCM-Correlation) were found to be the independent predictors in discrimination, of which AUC values were 0.80 and 0.75, respectively. Besides, the above two texture features (Histo-Skewness and GLCM-Contrast) were suggested to be associated with signal intensity on the contrast-enhanced image. Conclusion. Signal intensity on the contrast-enhanced image was the most significant MR image feature in differentiation between pituitary adenoma and Rathke cleft cyst, and texture features also showed promising and practical ability in discrimination. Moreover, two types of features could be coordinated with each other.

Case of Acromegaly Caused by Rathke Cleft Cyst Mimicking Plurihormonal Pituitary Adenoma

2019 ◽  
Vol 126 ◽  
pp. 570-575
Author(s):  
Yusuke Morinaga ◽  
Kouhei Nii ◽  
Kimiya Sakamoto ◽  
Ritsurou Inoue ◽  
Takafumi Mitsutake ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Rathke Cleft Cyst ◽  
Plurihormonal Pituitary Adenoma

scholarly journals Pituitary autoantibodies in patients with hypopituitarism and their relatives

1998 ◽  
Vol 157 (3) ◽  
pp. 475-480 ◽  
Author(s):  
S Stromberg ◽  
P Crock ◽  
A Lernmark ◽  
AL Hulting
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Gland ◽  
Sella Turcica ◽  
Lymphocytic Hypophysitis ◽  
Human Pituitary ◽  
Endocrine Disease ◽  
Cytosolic Protein ◽  
Organ Specific ◽  
Immunological Process ◽  
End Stage

Autoantibodies to human pituitary cytosol proteins were determined by immunoblotting in sera from patients with hypopituitarism and their relatives. Reactivity to an M(r) 49,000 protein was significantly more frequent in patients (6/21 (28%) P < 0.05) as well as in relatives (10/35 (28%) P < 0.02) compared with controls (3/44 (6.8%)). Autoantibodies to this particular protein have previously been detected in sera from 70% of patients with biopsy-proven lymphocytic hypophysitis. Unlike patients with biopsy-proven lymphocytic hypophysitis, none of the patients in this study presented with a suspected pituitary adenoma or showed an enlarged sella turcica. Cisternal herniation was seen in 6/21 patients and this may very well represent the end stage of lymphocytic hypophysitis. Since organ specific autoantibodies are frequent in patients with autoimmune endocrine disease as well as in their unaffected relatives, autoantibodies to this M(r) 49,000 pituitary cytosolic protein may represent markers for an immunological process affecting the pituitary gland.

The Coexistence of Growth Hormone-Producing Pituitary Adenoma and Rathke Cleft Cyst

2018 ◽  
Vol 29 (7) ◽  
pp. 1887-1889 ◽  
Author(s):  
Chao Tang ◽  
Liang Qiao ◽  
Chunyu Zhong ◽  
Jin Yang ◽  
Junhao Zhu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Rathke Cleft Cyst

scholarly journals Lymphocytic Hypophysitis Occurring Simultaneously with a Functioning Pituitary Adenoma

2008 ◽  
Vol 55 (4) ◽  
pp. 729-735 ◽  
Author(s):  
Daniel J. CUTHBERTSON ◽  
Dave RITCHIE ◽  
Daniel CROOKS ◽  
Gavin MAIN ◽  
Colin SMITH ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Lymphocytic Hypophysitis

scholarly journals Rathke Cleft Cyst with a Coexisting Gonadotropin Producing Pituitary Adenoma

2015 ◽  
Vol 05 (03) ◽  
pp. 71-75 ◽  
Author(s):  
Chi-Man Yip ◽  
Hui-Hwa Tseng ◽  
Shu-Shong Hsu ◽  
Huang-I Hsu
Keyword(s):  
Pituitary Adenoma ◽  
Rathke Cleft Cyst

Concurrent lymphocytic hypophysitis and pituitary adenoma

2006 ◽  
Vol 105 (2) ◽  
pp. 309-314 ◽  
Author(s):  
Shaye I. Moskowitz ◽  
Amir Hamrahian ◽  
Richard A. Prayson ◽  
Mercedes Pineyro ◽  
Robert R. Lorenz ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Sella Turcica ◽  
Mass Effect ◽  
Lymphocytic Infiltration ◽  
Lymphocytic Hypophysitis ◽  
Null Cell ◽  
History Of ◽  
Concurrent Development ◽  
Lymphocytic Adenohypophysitis ◽  
Lesion Growth

✓Lymphocytic hypophysitis (LyH) is an uncommon intrasellar lesion characterized by lymphocytic infiltration of the adenohypophysis. Evidence suggests that the cause is autoimmune, and the symptoms are usually related to either a mass effect or endocrine dysfunction. Lymphocytic hypophysitis has been described rarely in the setting of other simultaneous pathological processes that involve the pituitary and sella turcica, and is postulated to arise from an intrinsic inflammatory response. The authors report the case of a 43-year-old woman who presented with a 2-month history of galactorrhea and pseudohyperprolactinemia secondary to a 10-mm lesion within an enlarged pituitary gland. She was nulliparous and had no contributory medical history. Serial neuroimaging performed over a 2-year period demonstrated lesion growth, and visual deficits had developed; together these warranted surgical intervention. A transsphenoidal resection was performed. Microscopic and immunohistopathological examinations revealed a nonsecreting pituitary adenoma with concurrent lymphocytic adenohypophysitis. This is the first documented case of LyH in the setting of a null-cell pituitary adenoma. The authors review the related literature and outline potential mechanisms for the concurrent development of LyH and a pituitary adenoma.

Intractable Rathke Cleft Cyst Hidden Behind Coexisting Giant Pituitary Adenoma

2019 ◽  
Vol 124 ◽  
pp. 9-11 ◽  
Author(s):  
Fumihiko Nishimura ◽  
Yong-Soo Park ◽  
Yasushi Motoyama ◽  
Ichiro Nakagawa ◽  
Shuichi Yamada ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Giant Pituitary Adenoma ◽  
Rathke Cleft Cyst
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