scholarly journals Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas

Epigenetics ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. 883-891 ◽  
Author(s):  
Justin Colacino ◽  
Anna Arthur ◽  
Dana C. Dolinoy ◽  
Maureen Sartor ◽  
Sonia Duffy ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Dietary Intake ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Abstract 2642: Dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas

2012 ◽  
Author(s):  
Anna E. Arthur ◽  
Justin A. Colacino ◽  
Sonia A. Duffy ◽  
Dana C. Dolinoy ◽  
Jeffrey E. Terrell ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Dietary Intake ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas

2005 ◽  
Vol 14 (2) ◽  
pp. 320-321
Author(s):  
Mehmet Gunduz ◽  
Esra Gunduz ◽  
Byung-Moo Min ◽  
Gene Lee ◽  
Ji-Jun Lim ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Mutation Analysis ◽  
Squamous Cell ◽  
Genomic Structure ◽  
Squamous Cell Carcinomas

scholarly journals HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA

Oncogene ◽  
2000 ◽  
Vol 19 (7) ◽  
pp. 870-877 ◽  
Author(s):  
Gregory I Frost ◽  
Gayatry Mohapatra ◽  
Tim M Wong ◽  
Antonei Benjamin Csóka ◽  
Joe W Gray ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Squamous Cell Carcinomas ◽  
Aberrant Splicing ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

Epigenetics ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. 1195-1212 ◽  
Author(s):  
Luka de Vos ◽  
Ingela Grünwald ◽  
Emma Grace Bawden ◽  
Jörn Dietrich ◽  
Kathrin Scheckenbach ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

DNA Methylation Leaves Its Mark in Head and Neck Squamous Cell Carcinomas (HNSCC)

2004 ◽  
Vol 5 (6) ◽  
pp. 489-498 ◽  
Author(s):  
L. Smith ◽  
C. Plass
Keyword(s):  
Dna Methylation ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Abstract 537: TRAF3 serves as a tumor suppressor in HPV-associated head and neck squamous cell carcinomas

2017 ◽  
Author(s):  
Tony W. Chen ◽  
Jialing Zhang ◽  
Xinping Yang ◽  
Zhong Chen ◽  
Carter Van Waes
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

scholarly journals Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx

2016 ◽  
Vol 34 (34) ◽  
pp. 4132-4141 ◽  
Author(s):  
Ankur Chakravarthy ◽  
Stephen Henderson ◽  
Stephen M. Thirdborough ◽  
Christian H. Ottensmeier ◽  
Xiaoping Su ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Squamous Cell ◽  
Survival Data ◽  
Squamous Cell Carcinomas ◽  
Causal Role ◽  
Anatomic Site ◽  
Hpv Status

Purpose In squamous cell carcinomas of the head and neck (HNSCC), the increasing incidence of oropharyngeal squamous cell carcinomas (OPSCCs) is attributable to human papillomavirus (HPV) infection. Despite commonly presenting at late stage, HPV-driven OPSCCs are associated with improved prognosis compared with HPV-negative disease. HPV DNA is also detectable in nonoropharyngeal (non-OPSCC), but its pathogenic role and clinical significance are unclear. The objectives of this study were to determine whether HPV plays a causal role in non-OPSCC and to investigate whether HPV confers a survival benefit in these tumors. Methods Meta-analysis was used to build a cross-tissue gene-expression signature for HPV-driven cancer. Classifiers trained by machine-learning approaches were used to predict the HPV status of 520 HNSCCs profiled by The Cancer Genome Atlas project. DNA methylation data were similarly used to classify 464 HNSCCs and these analyses were integrated with genomic, histopathology, and survival data to permit a comprehensive comparison of HPV transcript-positive OPSCC and non-OPSCC. Results HPV-driven tumors accounted for 4.1% of non-OPSCCs. Regardless of anatomic site, HPV+ HNSCCs shared highly similar gene expression and DNA methylation profiles; nonkeratinizing, basaloid histopathological features; and lack of TP53 or CDKN2A alterations. Improved overall survival, however, was largely restricted to HPV-driven OPSCCs, which were associated with increased levels of tumor-infiltrating lymphocytes compared with HPV-driven non-OPSCCs. Conclusion Our analysis identified a causal role for HPV in transcript-positive non-OPSCCs throughout the head and neck. Notably, however, HPV-driven non-OPSCCs display a distinct immune microenvironment and clinical behavior compared with HPV-driven OPSCCs.

scholarly journals MicoRNA-451 is a novel tumor suppressor via targeting c-myc in head and neck squamous cell carcinomas

2015 ◽  
Vol 11 (6) ◽  
pp. 216 ◽  
Author(s):  
Zhenmin Lu ◽  
Huimin Wang ◽  
Guozheng Zhang ◽  
Zhiyan Wu ◽  
Baocai Lu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas
Sign in / Sign up

Export Citation Format

Share Document