scholarly journals Matrix factorization-based data fusion for drug-induced liver injury prediction

2014 ◽  
Vol 2 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Marinka Žitnik ◽  
Blaž Zupan
Keyword(s):  
Liver Injury ◽  
Data Fusion ◽  
Matrix Factorization ◽  
Drug Induced ◽  
Injury Prediction ◽  
Drug Induced Liver Injury

scholarly journals In Silico Prediction of Drug-Induced Liver Injury Based on Ensemble Classifier Method

2019 ◽  
Vol 20 (17) ◽  
pp. 4106 ◽  
Author(s):  
Wang ◽  
Xiao ◽  
Chen ◽  
Wang
Keyword(s):  
Liver Injury ◽  
Drug Research ◽  
Molecular Descriptors ◽  
Ensemble Classifier ◽  
Key Factors ◽  
Drug Induced ◽  
Molecular Fingerprints ◽  
Injury Prediction ◽  
Drug Induced Liver Injury ◽  
Fold Cross Validation

Drug-induced liver injury (DILI) is a major factor in the development of drugs and the safety of drugs. If the DILI cannot be effectively predicted during the development of the drug, it will cause the drug to be withdrawn from markets. Therefore, DILI is crucial at the early stages of drug research. This work presents a 2-class ensemble classifier model for predicting DILI, with 2D molecular descriptors and fingerprints on a dataset of 450 compounds. The purpose of our study is to investigate which are the key molecular fingerprints that may cause DILI risk, and then to obtain a reliable ensemble model to predict DILI risk with these key factors. Experimental results suggested that 8 molecular fingerprints are very critical for predicting DILI, and also obtained the best ratio of molecular fingerprints to molecular descriptors. The result of the 5-fold cross-validation of the ensemble vote classifier method obtain an accuracy of 77.25%, and the accuracy of the test set was 81.67%. This model could be used for drug‐induced liver injury prediction.

In-silico approach for drug induced liver injury prediction: Recent advances

2018 ◽  
Vol 295 ◽  
pp. 288-295 ◽  
Author(s):  
Neha Saini ◽  
Shikha Bakshi ◽  
Sadhna Sharma
Keyword(s):  
Liver Injury ◽  
In Silico ◽  
Drug Induced ◽  
Injury Prediction ◽  
Drug Induced Liver Injury ◽  
Recent Advances

scholarly journals In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties

2017 ◽  
Vol 157 (2) ◽  
pp. 487-499 ◽  
Author(s):  
Robert W. Yucha ◽  
Kan He ◽  
Qin Shi ◽  
Lining Cai ◽  
Yukie Nakashita ◽  
...  
Keyword(s):  
Liver Injury ◽  
Physicochemical Properties ◽  
Efflux Transporter ◽  
Drug Induced ◽  
Injury Prediction ◽  
Drug Induced Liver Injury ◽  
Prediction Criteria

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Drug induced liver injury associated with Flupirtine in 6 cases

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
C Agne ◽  
K Rifai ◽  
HH Kreipe ◽  
MP Manns ◽  
F Puls
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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