scholarly journals Erratum: Lacticaseibacillus casei AMBR2 Restores Airway Epithelial Integrity in Chronic Rhinosinusitis With Nasal Polyps

2022 ◽  
Vol 14 (1) ◽  
pp. 146
Author(s):  
Katleen Martens ◽  
Ilke De Boeck ◽  
Katarina Jokicevic ◽  
Filip Kiekens ◽  
Ricard Farré ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Airway Epithelial ◽  
Epithelial Integrity

scholarly journals Lacticaseibacillus casei AMBR2 Restores Airway Epithelial Integrity in Chronic Rhinosinusitis With Nasal Polyps

2021 ◽  
Vol 13 (4) ◽  
pp. 560
Author(s):  
Katleen Martens ◽  
Ilke De Boeck ◽  
Katarina Jokicevic ◽  
Filip Kiekens ◽  
Ricard Farré ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Airway Epithelial ◽  
Epithelial Integrity

scholarly journals Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Emilie Bequignon ◽  
David Mangin ◽  
Justine Bécaud ◽  
Jennifer Pasquier ◽  
Christelle Angely ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Airway Epithelial Cell ◽  
Airway Epithelial ◽  
Cell Dysfunction

scholarly journals Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis

Biomolecules ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1568
Author(s):  
Yoshimasa Imoto ◽  
Tetsuji Takabayashi ◽  
Masafumi Sakashita ◽  
Yukinori Kato ◽  
Kanako Yoshida ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Leukemic Cell ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Immunofluorescence Study ◽  
Expression Levels ◽  
Interleukin 33 ◽  
Mrna Expression Levels

Background: The pathological features of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) tissues include an eosinophilic infiltration pattern (eosinophilic CRS (ECRS)) or a less eosinophilic pattern (non-ECRS). Recently, it has been suggested that 15-lipoxygenase 1 (15-LOX-1) may have significant roles in allergic disease; however, the significance of 15-LOX-1 in CRS is not well understood. The objective of this study was to demonstrate the expression of 15-LOX-1 in CRS. Methods: The mRNA expression levels of 15-LOX-1 and periostin in nasal tissues were measured by quantitative real-time polymerase chain reaction. We also performed an immunofluorescence study of nasal tissues. Cells of the Eol-1 eosinophilic leukemic cell line were stimulated with interleukin-33 to test the induction of 15-LOX-1. Results: The expression level of 15-LOX-1 mRNA in nasal polyps (NPs) was significantly higher in ECRS patients than in non-ECRS patients. The immunofluorescence study revealed that both airway epithelial cells and eosinophils in NPs expressed 15-LOX-1. A significant correlation was seen between the number of eosinophils and the mRNA expression levels of 15-LOX-1 and periostin in nasal polyps. Moreover, interleukin-33 enhanced 15-LOX-1 expression in Eol-1 cells. Conclusions: 15-LOX-1 was shown to be a significant molecule that facilitates eosinophilic inflammation in ECRS.

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