Drug synergism: The combined effects of fluoxetine and memantine on an animal model of obsessive compulsive disorder

2011 ◽  
Vol 02 (01) ◽  
Author(s):  
Raphael Wald
Keyword(s):  
Animal Model ◽  
Obsessive Compulsive Disorder ◽  
Drug Synergism ◽  
Combined Effects ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Psychostimulant-Induced Behavior as an Animal Model of Obsessive-Compulsive Disorder: An Ethological Approach to the Form of Compulsive Rituals

CNS Spectrums ◽  
2005 ◽  
Vol 10 (3) ◽  
pp. 191-202 ◽  
Author(s):  
David Eilam ◽  
Henry Szechtman
Keyword(s):  
Animal Model ◽  
Obsessive Compulsive Disorder ◽  
Rat Model ◽  
Receptor Agonist ◽  
Dopamine Receptor Agonist ◽  
Compulsive Behavior ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Dopaminergic Mechanisms ◽  
Motor Acts

AbstractRats treated chronically with the D2/D3, dopamine receptor agonist quinpirole show a pattern of behavior that meets a set of ethologically derived criteria of compulsive behavior in obsessive-compulsive disorder (OCD). Moreover, in both quinpirole-treated rats and OCD patients, the structure of compulsive rituals appear similar in being composed of relatively few motor acts that are organized in a flexible yet recurrent manner. In addition, the development of compulsive behavior in quinpirole-treated rats is attenuated by the OCD pharmacotherapeutic drug clomipramine. These similarities support the validity of quinpirole-treated rats as a psychostimulant-induced animal model of OCD. Considering that the induction of compulsive behavior in the rat model involves chronic hyperstimulation of dopamine receptors, this raises the possibility that dopaminergic mechanisms may play a role in OCD, at least in some subtypes of this disorder.

5-HT2C receptor involvement in the control of persistence in the Reinforced Spatial Alternation animal model of obsessive–compulsive disorder

2013 ◽  
Vol 243 ◽  
pp. 176-183 ◽  
Author(s):  
Vassiliki-Maria Papakosta ◽  
Stamatina Kalogerakou ◽  
Dimitris Kontis ◽  
Eleni Anyfandi ◽  
Eirini Theochari ◽  
...  
Keyword(s):  
Animal Model ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Spatial Alternation

Reinforced Spatial Alternation as an Animal Model of Obsessive-Compulsive Disorder (OCD): Investigation of 5-HT2C and 5-HT1D Receptor Involvement in OCD Pathophysiology

2005 ◽  
Vol 57 (10) ◽  
pp. 1176-1185 ◽  
Author(s):  
Eleftheria Tsaltas ◽  
Dimitris Kontis ◽  
Sofia Chrysikakou ◽  
Haralambos Giannou ◽  
Angeliki Biba ◽  
...  
Keyword(s):  
Animal Model ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Spatial Alternation
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