Ovarian Heterotopic Pregnancy after Ovulation Induction with Clomiphene Citrate

2011 ◽  
Vol 01 (01) ◽  
Author(s):  
Lena El Hachem ◽  
Daniel E. Stein ◽  
Martin D. Keltz M ◽  
Matthew A. Lederman
2006 ◽  
Vol 274 (3) ◽  
pp. 181-183 ◽  
Author(s):  
M. Murat Naki ◽  
Cevahir Tekcan ◽  
Arzu Uysal ◽  
Kadir Güzin ◽  
Neşe Yücel

2014 ◽  
Vol 7 (2) ◽  
pp. 40-42 ◽  
Author(s):  
B Sharma

We report a combined intra-uterine and ruptured tubal pregnancy following ovulation induction by clomiphene citrate(CC).She was a 35 year old multigravida who presented with a ruptured tubal pregnancy and underwent right salphingectomy. Three months later, she presented with amenorrhea from the time of operation and an intra-uterine pregnancy was confirmed. Previous ultrasound at her initial presentation, did not reveal an intra-uterine pregnancy. The second ultrasound dating indicated that the intra-uterine conception had occurred before the tubal pregnancy was diagnosed. Therefore, a high index of suspicion for heterotopic pregnancy is needed in woman taking ovulation inducing drugs. DOI: http://www.dx.doi.org/10.3126/njog.v7i2.11142   Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 2 / Issue 14 / July-Dec, 2012 / 40-42


2009 ◽  
Vol 22 (2) ◽  
pp. 287-288
Author(s):  
S Jesmin ◽  
N Akhte ◽  
N Naha ◽  
N Shamima

We report a combined intra-uterine and ruptured tubal pregnancy following ovulation induction by clomiphene citrate (cc) and timed intercourse. The diagnosis of heterotopic pregnancy (HP) is the major problem until occurrence of tubal rupture. Because HP is a life threatening condition, the diagnosis should be made as soon as possible. In a spontaneous conception HP is a rare event. The risk of HP significantly increases after ovulation induction. Clomiphene itself should be associated with a high HP rare. We present a case with normally developing intra uterine singleton pregnancy successfully with synchronous tubal pregnancy following ovulation induction by cc.TAJ 2009; 22(1): 287-288


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ayumu Ito ◽  
Takamasa Furukawa ◽  
Kentaro Nakaoka ◽  
Rika Hayashi ◽  
Tadashi Namihira ◽  
...  

At 22 days after intrauterine insemination with ovulation induction using clomiphene citrate at a previous hospital, a 30-year-old woman was admitted to our hospital owing to right lower quadrant abdominal pain. We diagnosed threatened abortion because of a gestational sac in the uterus on transvaginal ultrasonography. The next day, she complained of increased abdominal pain. Transvaginal ultrasonography revealed a gestational sac-like structure in the echo free space. She was diagnosed with heterotopic pregnancy due to a ruptured right tubal pregnancy, underwent laparoscopic right salpingectomy. Rupture of a gestational age of 5 weeks is extremely rare. If this was a case of a heterotopic pregnancy due to superfetation, it could be explained as this clinical course. When a pregnant woman develops abdominal pain, heterotopic pregnancies should not be excluded from the differential diagnosis, and the possibility of superfetation should be taken into consideration.


QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Mohamed Nour El-Din Hashaad ◽  
Reda Mokhtar Kamal Ghanem ◽  
Sara Abouelfath Abouelasrar Gad Dawoud

Abstract Background Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders affecting females in their reproductive age. In PCOS, an imbalance between androgens, anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH), cause a halt of follicular growth. Insulin resistance (IR) is another important component of PCOS. There is increasing evidence that vitamin D affects insulin and glucose metabolism, Vitamin D plays a vital role in the regulation of glucose-insulin homeostasis. Objectives to assess the efficacy of vitamin D supplementation in improving ovulation induction in PCOS women (1ry outcome) and increasing pregnancy rate (secondary outcome). Patients and Methods 120 women diagnosed PCOS according to Rotterdam criteria and were resistant to CC treatment were randomly allocated into equal two groups: Group V: number of 60 patients received cholecalciferol + Metformin for 2 months. Group C: 60 patients received Metformin 2 months. After two months from the start:Both study groups started induction with Clomiphene Citrate added every month starting from the 3rd month to the 5th month (3 cycles of ovulation induction) in addition to previous drugs mentioned. Results In our study results, regulation of menstrual cycle occured in 63.6% of women who recieved vitamin D + metformin (group V) and ovulation was confirmed in 34.5% of the total number (55 women). Later, 18% of them got pregnant after 3 months of treatment. Added to that 16 women out of 39 (41%) got pregnant by the end of the follow up period with cumulative pregnancy rate (53%). On the other hand menstrual regularity in (group C: metformin) recorded 61% with ovulation percentage of 26.9% (n = 54). Followed by 14.8% pregnancy rate at the 3rd month., which increased to 27.5% by the end of the study out of 47.5% ovulated women (n = 40). Cumulative pregnancy rate 40%. Conclusion From the current study we can conclude that there is no significant difference of adding vitamin D to CC resistant PCOS regarding ovulation and pregnancy rates. However, it can augment metformin action and improves its outcome.


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