Exploring potential of di-organotin Schiff base compounds as anti-cancer agents

2018 ◽  
Vol 07 ◽  
Author(s):  
Navjot S Batth
Keyword(s):  
Schiff Base ◽  
Anti Cancer

SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF SOME SCHIFF BASES OF 1, 3, 4-OXADIAZOLE

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 12-17
Author(s):  
Manpreet Kaur ◽  
S. Singh ◽  
Keyword(s):  
Schiff Base ◽  
Growth Inhibition ◽  
Anticancer Activity ◽  
Maximum Growth ◽  
Schiff Base Derivatives ◽  
Control Growth ◽  
Anti Cancer ◽  
Oxadiazole Derivatives ◽  
Cancer Activity ◽  
Mcf 7

A new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives has been synthesized with the help of different aromatic benzaldehydes and final compounds were characterized by FTIR and 1H NMR. 2,5- disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of Schiff base derivatives with 2,5-disubstituted-1,3,4-oxadiazoles. All the synthesized compounds were screened for their anticancer activity. These compounds were evaluated for their anticancer activity against various cancer cell lines. Five of the compounds possessed good to moderate anti-cancer activity. Three of the synthesized compounds i.e. 6a, 6f and 6g were found to possess maximum growth inhibition. The order for the % control growth inhibition of MCF-7 was found to be 6a>6f>6g>5b>6h, as shown in Table II-VI.

scholarly journals Biomolecular Interaction, Anti-Cancer and Anti-Angiogenic Properties of Cobalt(III) Schiff Base Complexes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Subramanian Ambika ◽  
Yesaiyan Manojkumar ◽  
Sankaralingam Arunachalam ◽  
Balakrishnan Gowdhami ◽  
Kishore Kumar Meenakshi Sundaram ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Biomolecular Interaction ◽  
Anti Cancer

scholarly journals Synthesis and Characterization of some new Formazan Derivatives from 2-Amino-4-Hydroxy-6-Methyl Pyrimidine and Study the Biological Activity (Anti-Bacteria and Anti-Cancer)

2020 ◽  
Vol 11 (01) ◽  
pp. 53-59
Author(s):  
Shaimaa Adnan ◽  
Abdullah Shakir
Keyword(s):  
Fourier Transform ◽  
Biological Activity ◽  
Schiff Base ◽  
Infrared Spectroscopy ◽  
13C Nmr ◽  
Synthesis And Characterization ◽  
Compound A ◽  
Anti Cancer ◽  
Base Derivative

This study involves a synthesis of some formazan derivatives starting from react chloro acetyl chlorid with 2-amino-4-hydroxy-6-methyl pyrimidine to gate compound (a), (a) react with hydrazine hydrate to give compound (b) also (b) react with 3-4-dimethoxy benzaldehyd to product Schiff base derivative (c) then (c) react with deferent amin derivatives to get formazan derivatives. All these compounds characterized by 13C-NMR, fourier transform infrared spectroscopy (FTIR), 1HMNR. After that, we study the biological activity for all formazan derivatives toward two different kinds of bacteria and anti-cancer.

Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties

2020 ◽  
Vol 499 ◽  
pp. 119186 ◽  
Author(s):  
Shengshi Jiang ◽  
Honghui Ni ◽  
Fen Liu ◽  
Shanshan Gu ◽  
Ping Yu ◽  
...  
Keyword(s):  
Schiff Base ◽  
Crystal Structures ◽  
Anti Cancer

Designing of novel zinc(ii) Schiff base complexes having acyl hydrazone linkage: study of phosphatase and anti-cancer activities

2020 ◽  
Vol 49 (4) ◽  
pp. 1232-1240 ◽  
Author(s):  
Sanchari Dasgupta ◽  
Suhana Karim ◽  
Saswati Banerjee ◽  
Moumita Saha ◽  
Krishna Das Saha ◽  
...  
Keyword(s):  
Schiff Base ◽  
Linkage Study ◽  
Schiff Base Complexes ◽  
Anti Cancer ◽  
Acyl Hydrazone

The phosphatase and anti-cancer activities of three novel acyl hydrazone based zinc(ii) Schiff base complexes have been unveiled.

Hydrophobicity may enhance membrane affinity and anti-cancer effects of Schiff base vanadium(v) catecholate complexes

2019 ◽  
Vol 48 (19) ◽  
pp. 6383-6395 ◽  
Author(s):  
Debbie C. Crans ◽  
Jordan T. Koehn ◽  
Stephanie M. Petry ◽  
Caleb M. Glover ◽  
Asanka Wijetunga ◽  
...  
Keyword(s):  
Schiff Base ◽  
Cellular Uptake ◽  
Hydrolytic Stability ◽  
Membrane Affinity ◽  
Anti Cancer ◽  
Cancer Activity

Hydrophobicity may increase the hydrolytic stability of vanadium(v) catecholate complexes enabling rapid cellular uptake of the intact complex exhibiting potent anti-cancer activity.

Synthesis, DNA and BSA binding, in vitro anti-proliferative and in vivo anti-angiogenic properties of some cobalt(iii) Schiff base complexes

2019 ◽  
Vol 43 (28) ◽  
pp. 11391-11407 ◽  
Author(s):  
Yesaiyan Manojkumar ◽  
Subramanian Ambika ◽  
Rasu Arulkumar ◽  
Balakrishnan Gowdhami ◽  
Perumalsamy Balaji ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Medicinal Chemistry ◽  
Mechanisms Of Action ◽  
Schiff Base Complexes ◽  
Bsa Binding ◽  
Anti Cancer ◽  
Substantial Interest

In the recent times metal complexes with dual mechanisms of action, anti-cancer and anti-angiogenic, have gained substantial interest in the field of medicinal chemistry.

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