Hydrophobicity may enhance membrane affinity and anti-cancer effects of Schiff base vanadium(v) catecholate complexes

2019 ◽  
Vol 48 (19) ◽  
pp. 6383-6395 ◽  
Author(s):  
Debbie C. Crans ◽  
Jordan T. Koehn ◽  
Stephanie M. Petry ◽  
Caleb M. Glover ◽  
Asanka Wijetunga ◽  
...  
Keyword(s):  
Schiff Base ◽  
Cellular Uptake ◽  
Hydrolytic Stability ◽  
Membrane Affinity ◽  
Anti Cancer ◽  
Cancer Activity

Hydrophobicity may increase the hydrolytic stability of vanadium(v) catecholate complexes enabling rapid cellular uptake of the intact complex exhibiting potent anti-cancer activity.

SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF SOME SCHIFF BASES OF 1, 3, 4-OXADIAZOLE

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 12-17
Author(s):  
Manpreet Kaur ◽  
S. Singh ◽  
Keyword(s):  
Schiff Base ◽  
Growth Inhibition ◽  
Anticancer Activity ◽  
Maximum Growth ◽  
Schiff Base Derivatives ◽  
Control Growth ◽  
Anti Cancer ◽  
Oxadiazole Derivatives ◽  
Cancer Activity ◽  
Mcf 7

A new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives has been synthesized with the help of different aromatic benzaldehydes and final compounds were characterized by FTIR and 1H NMR. 2,5- disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of Schiff base derivatives with 2,5-disubstituted-1,3,4-oxadiazoles. All the synthesized compounds were screened for their anticancer activity. These compounds were evaluated for their anticancer activity against various cancer cell lines. Five of the compounds possessed good to moderate anti-cancer activity. Three of the synthesized compounds i.e. 6a, 6f and 6g were found to possess maximum growth inhibition. The order for the % control growth inhibition of MCF-7 was found to be 6a>6f>6g>5b>6h, as shown in Table II-VI.

Biological promiscuity of a binuclear Cu(ii) complex of aminoguanidine Schiff base: DNA binding, anticancer activity and histidine sensing ability of the complex

2020 ◽  
Vol 44 (18) ◽  
pp. 7319-7328
Author(s):  
Antu Mondal ◽  
Chandrima Das ◽  
Montse Corbella ◽  
Antonio Bauzá ◽  
Antonio Frontera ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Activity ◽  
Fluorometric Determination ◽  
Dna Binding Activity ◽  
Anti Cancer ◽  
Cancer Activity

A binuclear Cu(ii) complex of aminoguanidine shows strong DNA binding activity and encouraging anti-cancer activity against HCT-16 cells. The complex can also be used for selective spectrophotomteric or fluorometric determination of histidine.

Schiff Bases and Complexes: A Review on Anti-Cancer Activity

2020 ◽  
Vol 20 (16) ◽  
pp. 1908-1917
Author(s):  
Garima Matela
Keyword(s):  
Inorganic Chemistry ◽  
Schiff Base ◽  
Side Effects ◽  
Antitumor Activity ◽  
Anticancer Activity ◽  
Schiff Bases ◽  
Tumor Cell Lines ◽  
Anti Cancer ◽  
New Anticancer Drugs ◽  
Cancer Activity

Development in the field of bio-inorganic chemistry increased the interest in Schiff base and its complexes due to its biological importance in many fields, including anticancer activity. Discovery of the antitumor activity of Schiff base and its complexes against various tumor cell lines fascinates the researchers to develop new anticancer drugs without any side effects. Thus, the present review focuses on the anticancer activity of Schiff bases and their metal complexes.

A peptide–drug hydrogel to enhance the anti-cancer activity of chlorambucil

2020 ◽  
Vol 8 (20) ◽  
pp. 5638-5646
Author(s):  
Qingxiang Guo ◽  
Yifan Liu ◽  
Ganen Mu ◽  
Lijun Yang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Peptide Drug ◽  
Cooling Process ◽  
Anti Cancer ◽  
Tumor Environment ◽  
Anti Tumor Activity ◽  
Cancer Activity

The CRB–FFF–cyclen could transform into a hydrogel via a heating–cooling process. The resulting hydrogel could be protonated in a tumor environment, which is beneficial for cellular uptake and anti-tumor activity.

Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells

2012 ◽  
Vol 689 (1-3) ◽  
pp. 45-55 ◽  
Author(s):  
Brian Duff ◽  
Venkat Reddy Thangella ◽  
Bernadette S. Creaven ◽  
Maureen Walsh ◽  
Denise A. Egan
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Mutagenic Potential ◽  
Anti Cancer ◽  
Hepatocarcinoma Cells ◽  
Cancer Activity
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