scholarly journals Vertebroplasty Using Calcium Phosphate Cement for Osteoporotic Vertebral Fractures: Study of Outcomes at a Minimum Follow-up of Two Years

2012 ◽  
Vol 6 (1) ◽  
pp. 34 ◽  
Author(s):  
Masato Nakano ◽  
Norikazu Hirano ◽  
Mineyuki Zukawa ◽  
Kayo Suzuki ◽  
Jinichiro Hirose ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Vertebral Fractures ◽  
Calcium Phosphate Cement ◽  
Osteoporotic Vertebral Fractures

Percutaneous transpedicular vertebroplasty with calcium phosphate cement in the treatment of osteoporotic vertebral compression and burst fractures

2002 ◽  
Vol 97 (3) ◽  
pp. 287-293 ◽  
Author(s):  
Masato Nakano ◽  
Norikazu Hirano ◽  
Kousou Matsuura ◽  
Hiroki Watanabe ◽  
Hideki Kitagawa ◽  
...  
Keyword(s):  
Back Pain ◽  
Calcium Phosphate ◽  
Pain Relief ◽  
Vertebral Fractures ◽  
Calcium Phosphate Cement ◽  
Content Type ◽  
Osteoporotic Vertebral Fractures ◽  
The Mean ◽  
Fine Print

Object. Osteoporotic vertebral fractures occasionally lead to late-onset collapse, kyphosis, persistent back pain, and disability. The authors describe a series of patients in whom they performed percutaneous vertebroplasty by using calcium phosphate cement (CPC) to obtain early pain relief and improve the integrity of the osteoporotic vertebral body (VB). Methods. Between August 2000 and February 2001, they performed 17 percutaneous transpedicular CPC-assisted vertebroplasty procedures in 16 patients who harbored thoracic or lumbar osteoporotic vertebral fractures. Following repositioning and curettage of the pathological soft tissues, CPC-assisted vertebroplasty was percutaneously performed in four patients with osteoporotic burst fracture and pseudarthrosis (Procedure A). In situ CPC-assisted vertebroplasty was performed in 12 patients with fresh vertebral compression fractures due to osteoporosis (Procedure B). Back pain and low-back pain were evaluated using a visual analog scale (VAS). The deformity index of the VB was measured on a lateral radiograph as the ratio of the VB's height (sum of measurements at anterior, middle, and posterior regions) to its longitudinal diameter. Based on VAS scores, pain was decreased in all patients immediately after surgery, and pain relief was maintained at the last follow up. The mean preoperative deformity index score of the VB was 1.43 in Procedure A and 1.67 in Procedure B; postoperatively scores improved to 1.59 and 1.93, respectively. At the 6-month follow-up examination, the mean deformity index score rebounded to 1.52 in Procedure A and 1.79 in Procedure B. Bone union was documented in all patients. Complications, such as a temporary respiratory insufficiency and a small amount of CPC leakage into the spinal canal, were observed in patients who underwent Procedure B. Conclusions. Percutaneous transpedicular CPC-assisted vertebroplasty is a minimally invasive procedure that provides early relief of pain and prevents vertebral collapse and pseudarthrosis in patients with osteoporotic vertebral fracture.

Calcium phosphate cement leakage after percutaneous vertebroplasty for osteoporotic vertebral fractures: risk factor analysis for cement leakage

2005 ◽  
Vol 2 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Masato Nakano ◽  
Norikazu Hirano ◽  
Hirokazu Ishihara ◽  
Yoshiharu Kawaguchi ◽  
Kousou Matsuura
Keyword(s):  
Calcium Phosphate ◽  
Epidural Space ◽  
Vertebral Fractures ◽  
Calcium Phosphate Cement ◽  
Cement Leakage ◽  
Therapeutic Effects ◽  
Content Type ◽  
Female Sex ◽  
Osteoporotic Vertebral Fractures ◽  
Fine Print

Object. The purpose of this study was to analyze the risk factors for leakage of calcium phosphate cement (CPC) after vertebroplasty for osteoporotic vertebral fractures and to determine whether the vertebral body (VB) leakage caused any changes in the therapeutic benefits. Methods. Between August 2000 and April 2002, the authors performed 65 CPC-assisted vertebroplasty procedures in 55 patients with thoracic or lumbar osteoporotic vertebral fractures. Back and low-back pain were evaluated using the visual analog scale and the duration of analgesic medication requirement. Factors related to CPC leakage and the postoperative outcome were analyzed. There was a small amount of VB CPC leakage in 23 cases. In 10 of 23 cases, leakage into the epidural space was found. Although VB CPC leakage was independently associated with high initial age, female sex, high bone mineral density (BMD), short injury—surgery interval, and injection via the unipedicular route in the logistic regression analysis, there was no factor associated with CPC leakage into the epidural space. Cement leakage into the epidural space reduced the immediate therapeutic effects on fracture-related pain (p = 0.0128). All patients in whom cement leaked into the epidural space had improved by the 2-week follow-up examination. Conclusions. Advanced initial age, female sex, high BMD, a short interval from injury to surgery, and injection via the unipedicular route may increase the incidence of CPC leakage. Cement leakage into the epidural space attenuated only the immediate therapeutic effects of CPC-assisted vertebroplasty.

scholarly journals Nonsurgical Corrective Union of Osteoporotic Vertebral Fracture with Once-Weekly Teriparatide

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Naohisa Miyakoshi ◽  
Akira Horikawa ◽  
Yoichi Shimada
Keyword(s):  
Vertebral Fracture ◽  
Fracture Healing ◽  
Clinical Experience ◽  
Vertebral Body ◽  
Vertebral Fractures ◽  
Surgical Intervention ◽  
Osteoporotic Vertebral Fracture ◽  
Kyphosis Angle ◽  
Osteoporotic Vertebral Fractures

Osteoporotic vertebral fractures usually heal with kyphotic deformities with subsidence of the vertebral body when treated conservatively. Corrective vertebral union using only antiosteoporotic pharmacotherapy without surgical intervention has not been reported previously. An 81-year-old female with osteoporosis presented with symptomatic fresh L1 vertebral fracture with intravertebral cleft. Segmental vertebral kyphosis angle (VKA) at L1 was 20° at diagnosis. Once-weekly teriparatide administration, hospitalized rest, and application of a thoracolumbosacral orthosis alleviated symptoms within 2 months. Corrective union of the affected vertebra was obtained with these treatments. VKA at 2 months after injury was 8° (correction, 12°) and was maintained as of the latest follow-up at 7 months. Teriparatide has potent bone-forming effects and has thus been expected to enhance fracture healing. Based on the clinical experience of this case, teriparatide may have the potential to allow correction of unstable vertebral fractures without surgical intervention.

Twelve-Months Follow-up in Forty-Nine Patients With Acute/Semiacute Osteoporotic Vertebral Fractures Treated Conservatively or With Percutaneous Vertebroplasty

Spine ◽  
2010 ◽  
Vol 35 (5) ◽  
pp. 478-482 ◽  
Author(s):  
Rikke Rousing ◽  
Karina L. Hansen ◽  
Mikkel O. Andersen ◽  
Stig M. Jespersen ◽  
Karsten Thomsen ◽  
...  
Keyword(s):  
Vertebral Fractures ◽  
Percutaneous Vertebroplasty ◽  
Osteoporotic Vertebral Fractures
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