scholarly journals Difference in Spinal Sagittal Alignment and Health-Related Quality of Life between Males and Females with Cervical Deformity

2017 ◽  
Vol 11 (6) ◽  
pp. 959-967 ◽  
Author(s):  
Shin Oe ◽  
Daisuke Togawa ◽  
Go Yoshida ◽  
Tomohiko Hasegawa ◽  
Yu Yamato ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sagittal Alignment ◽  
Health Related Quality ◽  
Sagittal Vertical Axis ◽  
Cervical Deformity ◽  
Spinal Sagittal Alignment ◽  
Related Quality ◽  
Health Related ◽  
Males And Females

<sec><title>Study Design</title><p>Large cohort study.</p></sec><sec><title>Purpose</title><p>To clarify spinal sagittal alignment and health-related quality of life (HRQOL) according to sex in volunteers aged &gt;50 years with cervical deformity (CD).</p></sec><sec><title>Overview of Literature</title><p>Adult spinal deformities, especially those associated with lumbosacral lesions, are more frequent in females; however, CD is observed to a greater extent in males.</p></sec><sec><title>Methods</title><p>We divided 656 volunteers (263 males, 393 females; age, 50–89 years [mean, 73 years]) as follows: males with CD (CDM; 82 patients); males without CD (NCDM, 181); females with CD (CDF, 36); and females without CD (NCDF, 357). CD was defined as C2–7 sagittal vertical axis (SVA) ≥40 mm. We measured pelvic tilt (PT), pelvic incidence minus lumbar lordosis (PI−LL), thoracic kyphosis, T1 slope, cervical lordosis, C7 SVA, and C2–7 SVA. HRQOL was evaluated using EuroQOL five dimensions questionnaire (EQ-5D).</p></sec><sec><title>Results</title><p>In CDM, NCDM, CDF, and NCDF groups, the respective parameters were as follows: PT: 15°, 14°, 26°, and 21°; PI−LL: 7°, 5°, 16°, and 10°; C2–7 SVA: 49, 24, 46, and 20 mm; C7 SVA: 61, 40, 75, and 47 mm; and EQ-5D: 0.82, 0.88, 0.78, and 0.81. PT and PI−LL were significantly greater in the CDF group than in the NCDF group (<italic>p</italic>&lt;0.05) but were not significantly different between CDM and NCDM groups. The CDF group already showed deterioration of spinopelvic alignment, although it was maintained in the CDM group. EQ-5D in showed significantly greater deterioration the CDM group than in the NCDM group; deterioration of lumbopelvic parameters had less influence in males (<italic>p</italic>&lt;0.05).</p></sec><sec><title>Conclusions</title><p>Sagittal spinal deformity may have different mechanisms in males and females. The deterioration of spinal sagittal alignment in males may originate from the cervical spine, and CD may be associated with HRQOL.</p></sec>

175. Intraoperative alignment goals for severe cervical deformity to achieve optimal improvements in health-related quality of life measures

2019 ◽  
Vol 19 (9) ◽  
pp. S84-S85
Author(s):  
Sohrab Virk ◽  
Peter G. Passias ◽  
Renaud Lafage ◽  
Eric O. Klineberg ◽  
Gregory M. Mundis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Cervical Deformity ◽  
Quality Of Life Measures ◽  
Related Quality ◽  
Health Related

Relationship between body mass index and sagittal vertical axis change as well as health-related quality of life in 564 patients after deformity surgery

2019 ◽  
Vol 31 (5) ◽  
pp. 697-702 ◽  
Author(s):  
Nitin Agarwal ◽  
Federico Angriman ◽  
Ezequiel Goldschmidt ◽  
James Zhou ◽  
Adam S. Kanter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vertical Axis ◽  
Patient Questionnaire ◽  
Health Related Quality ◽  
Sagittal Vertical Axis ◽  
Related Quality ◽  
Health Related ◽  
Secondary Outcomes ◽  
The Relationship

OBJECTIVEObesity, a condition that is increasing in prevalence in the United States, has previously been associated with poorer outcomes following deformity surgery, including higher rates of perioperative complications such as deep and superficial infections. To date, however, no study has examined the relationship between preoperative BMI and outcomes of deformity surgery as measured by spine parameters such as the sagittal vertical axis (SVA), as well as health-related quality of life (HRQoL) measures such as the Oswestry Disability Index (ODI) and Scoliosis Research Society–22 patient questionnaire (SRS-22). To this end, the authors sought to clarify the relationship between BMI and postoperative change in SVA as well as HRQoL outcomes.METHODSThe authors performed a retrospective review of a prospectively managed multicenter adult spinal deformity database collected and maintained by the International Spine Study Group (ISSG) between 2009 and 2014. The primary independent variable considered was preoperative BMI. The primary outcome was the change in SVA at 1 year after deformity surgery. Postoperative ODI and SRS-22 outcome measures were evaluated as secondary outcomes. Generalized linear models were used to model the primary and secondary outcomes at 1 year as a function of BMI at baseline, while adjusting for potential measured confounders.RESULTSIncreasing BMI (compared to BMI < 18) was not associated with change of SVA at 1 year postsurgery. However, BMIs in the obese range of 30 to 34.9 kg/m2, compared to BMI < 18 at baseline, were associated with poorer outcomes as measured by the SRS-22 score (estimated change −0.47, 95% CI −0.93 to −0.01, p = 0.04). While BMIs > 30 appeared to be associated with poorer outcomes as determined by the ODI, this correlation did not reach statistical significance.CONCLUSIONSBaseline BMI did not affect the achievable SVA at 1 year postsurgery. Further studies should evaluate whether even in the absence of a change in SVA, baseline BMIs in the obese range are associated with worsened HRQoL outcomes after spinal surgery.

scholarly journals Asthma control, lung function, nutritional status, and health-related quality of life: differences between adult males and females with asthma

2018 ◽  
Vol 44 (4) ◽  
pp. 273-278 ◽  
Author(s):  
Gabriele Carra Forte ◽  
Maria Luiza Hennemann ◽  
Paulo de Tarso Roth Dalcin
Keyword(s):  
Quality Of Life ◽  
Lung Function ◽  
Nutritional Status ◽  
Asthma Control ◽  
Health Related Quality ◽  
Asthma Patients ◽  
Related Quality ◽  
Health Related ◽  
Males And Females

ABSTRACT Objective: To evaluate health-related quality of life in asthma patients treated at a referral center in southern Brazil, identifying differences between male and female patients, as well as to evaluate differences between the males and females in terms of asthma control, lung function, and nutritional status. Methods: This was a cross-sectional study involving patients ≥ 18 years of age treated at an asthma outpatient clinic. We evaluated clinical parameters, lung function, nutritional status, and quality of life. Results: A total of 198 patients completed the study. The mean age was 56.2 ± 14.8 years, and 81.8% were female. The proportion of patients with uncontrolled asthma was higher among females than among males (63.0% vs. 44.4%; p = 0.041). The body mass index (BMI) and percentage of body fat were higher in females than in males (30.2 ± 5.8 kg/m2 vs. 26.9 ± 4.5 kg/m2 and 37.4 ± 6.4% vs. 26.5 ± 7.4%; p = 0.002 and p < 0.001, respectively). Quality of life was lower in females than in males in the following domains: symptoms (3.8 ± 1.5 vs. 4.6 ± 1.7; p = 0.006); activity limitation (3.6 ± 1.3 vs. 4.4 ± 1.5; p = 0.001); emotional function (3.6 ± 1.9 vs. 4.5 ± 1.7; p = 0.014); and environmental stimuli (3.2 ± 1.6 vs. 4.3 ± 1.9; p = 0.001). Conclusions: Male asthma patients appear to fare better than do female asthma patients in terms of health-related quality of life, asthma control, BMI, percentage of body fat, and comorbidities.

scholarly journals Heritability of Health-Related Quality of Life: SF-12 Summary Scores in a Population-Based Nationwide Twin Cohort

2013 ◽  
Vol 16 (3) ◽  
pp. 670-678 ◽  
Author(s):  
Troels Steenstrup ◽  
Ole Birger Pedersen ◽  
Jacob Hjelmborg ◽  
Axel Skytthe ◽  
Kirsten Ohm Kyvik
Keyword(s):  
Quality Of Life ◽  
Age Groups ◽  
Population Based ◽  
Age Group ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Males And Females ◽  
Danish Twin

Aim: The present study aims to estimate the relative importance of genetic and environmental factors for health-related quality of life (HRQL) measured by the 12-item Short-Form Health Survey (SF-12). Methods: The study was based on two Danish twin cohorts (46,417 twin individuals) originating from the nationwide, population-based Danish Twin Registry. The twins were approached by a mailed-out questionnaire in 2002. The questionnaire included the SF-12, information on demographic factors, and questions on a variety of specific diseases. Heritability of the SF-12 includes the physical component summary (PCS) and the mental component summary (MCS); and etiologically important variance components were estimated using multivariate biometric models. The respondents were stratified into six groups, based on age and sex. Results: A total of 33,794 (73%) individual twins responded to the survey. The SF-12 was completed by 29,619 individuals, which included 9,120 complete twin pairs. Overall, the best-fitting model explaining the variance of HRQL was the ACE model. The estimated heritability of the SF-12 was between 11% and 35%, whereas between 65% and 89% could be explained by unique environmental or stochastic factors in the different sex and age groups. The highest heritability was seen among older twins. In addition, the genetic correlation between MCS and PCS scores was low (0.07 and 0.23 for males and females, respectively) among younger and high (0.26 and 0.45 for males and females, respectively) in the oldest age group. Both the largest genetic influence on HRQL and the largest genetic overlap between the scores were seen in the oldest age group, which consisted of twins older than 55. The unique environmental correlation between MCS and PCS were generally negative. Conclusion: The heritability of HRQL differs between different age groups. In general, most of the variance in the SF-12 summary components was determined by unique environmental factors.

scholarly journals Normative values of spino-pelvic sagittal alignment, balance, age, and health-related quality of life in a cohort of healthy adult subjects

2016 ◽  
Vol 25 (11) ◽  
pp. 3675-3686 ◽  
Author(s):  
Kazuhiro Hasegawa ◽  
Masashi Okamoto ◽  
Shun Hatsushikano ◽  
Haruka Shimoda ◽  
Masatoshi Ono ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Healthy Adult ◽  
Sagittal Alignment ◽  
Normative Values ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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