scholarly journals Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages

2014 ◽  
Vol 13 (4) ◽  
pp. 9642-9649 ◽  
Author(s):  
W. Li ◽  
C. Du ◽  
H. Wang ◽  
C. Zhang
2020 ◽  
Vol 22 (2) ◽  
pp. 107-119
Author(s):  
Piotr Godek ◽  
Sebastian Szajkowski ◽  
Dominik Golicki

Background. Osteoarthritis is a global health problem. Approaches to symptomatic treatment of its consequences in­clude biological methods, including autologous serum. The aim of the study was to evaluate the effectiveness of Orthokine therapy in our experience. Material and methods. Retrospective analysis of 1000 cases. The results were evaluated on a modified McNab scale (A – excellent, B – good, C – fair, D – poor) two and six months after the end of therapy. The effectiveness of the therapy was estimated as the percentage of satisfactory (A or B) or unsatisfactory (C or D) results. Results. Osteoarthritis of the lumbar spine (n = 400) and knee joint (n = 219) was the most common diagnosis. The highest percentage of patients with a grade A or B result after 6 months was seen with therapy of tennis elbow enthesopathy (88.2%), rotator cuff tendinopathy (72.0%), Achilles tendon tendinopathy (75.0%) and in the early stages of osteoarthritis of the knee (75.9%) and small joints of the hand (77.0%). For cervical and lumbar discopathy, treatment efficacy was at 56.0-62.0% regardless of the size of the hernia. Unsatisfactory results (C and D) predominated in the group of patients with lumbar spinal stenosis (66.1%), wrist osteoarthritis (66.7%), and especially in late-stage hip osteoarthritis (85.3 %). For the largest groups, the frequency of unsatisfactory results was analyzed for selected age ranges. A significant increase in this parameter in subjects over 75 years of age was only seen in patients with severe knee osteoarthritis. Conclusions. 1. Orthokine therapy is highly effective in cases of tendinopathy, enthesopathy, osteoarthritis of the small joints of the hand and in early stages of knee osteoarthritis. 2. Satisfactory results are achieved in the treatment of cervical and lumbar discopathy, while unsatisfactory results prevail in severe degenerative changes in the knee and hip joints and in spinal canal stenosis.


2013 ◽  
Vol 29 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Renan Alves Resende ◽  
Sérgio Teixeira Fonseca ◽  
Paula Lanna Silva ◽  
Claudio Marcos Bedran Magalhães ◽  
Renata Noce Kirkwood

2014 ◽  
Vol 55 (5-6) ◽  
pp. 331-338
Author(s):  
Paula Regina M. S. Serrão ◽  
Fernando A. Vasilceac ◽  
Karina Gramani-Say ◽  
Giovanna C. Lessi ◽  
Rodrigo B. M. Reiff ◽  
...  

2021 ◽  
Vol 29 ◽  
pp. S11-S12
Author(s):  
S. Mattiello ◽  
P. João Francisco ◽  
K. Gramani-Say ◽  
C. Carvalho ◽  
P. Mendes da Silva Serrão

Author(s):  
George G. Cocks ◽  
Louis Leibovitz ◽  
DoSuk D. Lee

Our understanding of the structure and the formation of inorganic minerals in the bivalve shells has been considerably advanced by the use of electron microscope. However, very little is known about the ultrastructure of valves in the larval stage of the oysters. The present study examines the developmental changes which occur between the time of conception to the early stages of Dissoconch in the Crassostrea virginica(Gmelin), focusing on the initial deposition of inorganic crystals by the oysters.The spawning was induced by elevating the temperature of the seawater where the adult oysters were conditioned. The eggs and sperm were collected separately, then immediately mixed for the fertilizations to occur. Fertilized animals were kept in the incubator where various stages of development were stopped and observed. The detailed analysis of the early stages of growth showed that CaCO3 crystals(aragonite), with orthorhombic crystal structure, are deposited as early as gastrula stage(Figuresla-b). The next stage in development, the prodissoconch, revealed that the crystal orientation is in the form of spherulites.


Author(s):  
S. Mahajan

The evolution of dislocation channels in irradiated metals during deformation can be envisaged to occur in three stages: (i) formation of embryonic cluster free regions, (ii) growth of these regions into microscopically observable channels and (iii) termination of their growth due to the accumulation of dislocation damage. The first two stages are particularly intriguing, and we have attempted to follow the early stages of channel formation in polycrystalline molybdenum, irradiated to 5×1019 n. cm−2 (E > 1 Mev) at the reactor ambient temperature (∼ 60°C), using transmission electron microscopy. The irradiated samples were strained, at room temperature, up to the macroscopic yield point.Figure 1 illustrates the early stages of channel formation. The observations suggest that the cluster free regions, such as A, B and C, form in isolated packets, which could subsequently link-up to evolve a channel.


Sign in / Sign up

Export Citation Format

Share Document