scholarly journals Chelation therapy in liver diseases of childhood: Current status and response

2021 ◽  
Vol 13 (11) ◽  
pp. 1552-1567
Author(s):  
Jayendra Seetharaman ◽  
Moinak Sen Sarma
Keyword(s):  
Liver Diseases ◽  
Chelation Therapy ◽  
Current Status

scholarly journals Gene Therapy for Liver Cancers: Current Status from Basic to Clinics

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1865 ◽  
Author(s):  
Kenya Kamimura ◽  
Takeshi Yokoo ◽  
Hiroyuki Abe ◽  
Shuji Terai
Keyword(s):  
Gene Therapy ◽  
Liver Cancer ◽  
Liver Diseases ◽  
Malignant Tumors ◽  
Therapeutic Options ◽  
Endocrine Function ◽  
Current Status ◽  
Congenital Disease ◽  
Gene Therapies ◽  
Liver Cancers

The liver is a key organ for metabolism, protein synthesis, detoxification, and endocrine function, and among liver diseases, including hepatitis, cirrhosis, malignant tumors, and congenital disease, liver cancer is one of the leading causes of cancer-related deaths worldwide. Conventional therapeutic options such as embolization and chemotherapy are not effective against advanced-stage liver cancer; therefore, continuous efforts focus on the development of novel therapeutic options, including molecular targeted agents and gene therapy. In this review, we will summarize the progress toward the development of gene therapies for liver cancer, with an emphasis on recent clinical trials and preclinical studies.

scholarly journals Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia

2020 ◽  
Vol 9 (2) ◽  
pp. 289 ◽  
Author(s):  
Monica Borgatti ◽  
Emiliano Altamura ◽  
Francesca Salvatori ◽  
Elisabetta D’Aversa ◽  
Nicola Altamura
Keyword(s):  
Genetic Disease ◽  
Chelation Therapy ◽  
Translation Termination ◽  
Premature Termination Codon ◽  
Nonsense Suppression ◽  
Current Status ◽  
Nonsense Mutations ◽  
Nonsense Mediated Mrna Decay ◽  
Mrna Destabilization ◽  
Premature Translation Termination

Several types of thalassemia (including β039-thalassemia) are caused by nonsense mutations in genes controlling globin production, leading to premature translation termination and mRNA destabilization mediated by the nonsense mediated mRNA decay. Drugs (for instance, aminoglycosides) can be designed to suppress premature translation termination by inducing readthrough (or nonsense suppression) at the premature termination codon. These findings have introduced new hopes for the development of a pharmacologic approach to cure this genetic disease. In the present review, we first summarize the principle and current status of the chemical relief for the expression of functional proteins from genes otherwise unfruitful for the presence of nonsense mutations. Second, we compare data available on readthrough molecules for β0-thalassemia. The examples reported in the review strongly suggest that ribosomal readthrough should be considered as a therapeutic approach for the treatment of β0-thalassemia caused by nonsense mutations. Concluding, the discovery of molecules, exhibiting the property of inducing β-globin, such as readthrough compounds, is of great interest and represents a hope for several patients, whose survival will depend on the possible use of drugs rendering blood transfusion and chelation therapy unnecessary.

scholarly journals Current Status in the Therapy of Liver Diseases

2014 ◽  
Vol 15 (5) ◽  
pp. 7500-7512 ◽  
Author(s):  
Philipp Uhl ◽  
Gert Fricker ◽  
Uwe Haberkorn ◽  
Walter Mier
Keyword(s):  
Liver Diseases ◽  
Current Status

Current Status and Perspectives of Stem Cell Based Therapies for Liver Diseases

2012 ◽  
Vol 1 (3) ◽  
pp. 299-305
Author(s):  
Ahmed M. El-Gohary ◽  
Fadia M. Attia ◽  
Fawzy A. Khalil
Keyword(s):  
Stem Cell ◽  
Liver Diseases ◽  
Current Status

Current Status and Perspectives of Stem Cell Based Therapies for Liver Diseases

2011 ◽  
Vol 1 (3) ◽  
pp. 299-305
Author(s):  
Ahmed M. El-Gohary ◽  
Fadia M. Attia ◽  
Fawzy A. Khalil
Keyword(s):  
Stem Cell ◽  
Liver Diseases ◽  
Current Status

scholarly journals Current status of alcoholic liver diseases in Japan

Kanzo ◽  
2015 ◽  
Vol 56 (7) ◽  
pp. 366-368 ◽  
Author(s):  
Yoshinori Horie ◽  
Hirotoshi Ebinuma ◽  
Masahiro Kikuchi ◽  
Nobuhiro Nakamoto ◽  
Takanori Kanai
Keyword(s):  
Liver Diseases ◽  
Current Status ◽  
Alcoholic Liver Diseases

scholarly journals Current status of pruritus in chronic liver diseases and efficacy of nalfurafine hydrochloride

Kanzo ◽  
2017 ◽  
Vol 58 (9) ◽  
pp. 486-493 ◽  
Author(s):  
Ryoko Sumi ◽  
Kazuto Fukuda ◽  
Keiko Irishio ◽  
Michiyo Hattori ◽  
Yoshiyuki Sawai ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Chronic Liver ◽  
Current Status ◽  
Chronic Liver Diseases
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