scholarly journals Case Report: Rhino-orbital Mucormycosis Related to COVID-19: A Case Series Exploring Risk Factors

2021 ◽  
Author(s):  
Sushil Kumar Aggarwal ◽  
Upinder Kaur ◽  
Dolly Talda ◽  
Akshat Pandey ◽  
Sumit Jaiswal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Mechanisms ◽  
Case Series ◽  
Intracranial Extension ◽  
Newly Diagnosed ◽  
Steroid Use ◽  
Male Preponderance ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycemia resulting from diabetes which is a common comorbidity in COVID-19 patients, and indiscriminate steroid use has resulted in this surge. We report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted to our center between mid-April and early June 2021. The cases showed a male preponderance, two patients had loss of vision, and four of them showed intracranial extension of disease. Twelve patients had received steroids and 12 had preexisting or newly diagnosed diabetes, both steroid use and diabetes being the most common identified risk factors. Considering other possible risk factors, immunosuppressed state, antiviral or ayurvedic (Indian traditional) medications, and oxygen therapy were not associated with a definite risk of mucormycosis, because they were not present uniformly in the patients. We propose that COVID-19 itself, through molecular mechanisms, predisposes to mucormycosis, with other factors such as dysglycemia or steroid use increasing the risk.

scholarly journals Rhino-orbital mucormycosis related to COVID-19- A case series exploring risk factors

2021 ◽  
Author(s):  
Sushil Kumar Aggarwal ◽  
Upinder Kaur ◽  
Dolly Talda ◽  
Akshat Pandey ◽  
Sumit Jaiswal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Mechanisms ◽  
Common Factor ◽  
Case Series ◽  
Intracranial Extension ◽  
Management Protocol ◽  
Male Preponderance ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

Abstract There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycaemia due to diabetes present as a common comorbidity in these COVID-19 patients as well as indiscriminate steroid use has resulted in this surge. Here, we report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted at our center between mid-April and early June 2021. Out of the 13, the only common factor was COVID-19 at some time point before diagnosis of mucormycosis or coexistent with it. The cases showed a male preponderance and four of them showed intracranial extension of disease. Eleven of them had received steroids as part of COVID-19 management protocol and twelve of them had pre-existing or newly diagnosed diabetes. We have summarized other probable risk factors being considered such as immunosuppressed state, antiviral and Ayurvedic (Indian traditional) medications, oxygen therapy, with each of which we could not find a link of mucormycosis. We propose that COVID-19 itself through molecular mechanisms predisposes to mucormycosis, with other factors such as dysglycaemia providing a second hit.

scholarly journals Rhino-orbital mucormycosis related to COVID-19- A case series exploring risk factors

2021 ◽  
Author(s):  
Sushil Kumar Aggarwal ◽  
Upinder Kaur ◽  
Dolly Talda ◽  
Akshat Pandey ◽  
Sumit Jaiswal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Mechanisms ◽  
Common Factor ◽  
Case Series ◽  
Intracranial Extension ◽  
Management Protocol ◽  
Male Preponderance ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

Abstract There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycaemia due to diabetes present as a common comorbidity in these COVID-19 patients as well as indiscriminate steroid use has resulted in this surge. Here, we report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted at our center between mid-April and early June 2021. Out of the 13, the only common factor was COVID-19 at some time point before diagnosis of mucormycosis or coexistent with it. The cases showed a male preponderance and four of them showed intracranial extension of disease. Eleven of them had received steroids as part of COVID-19 management protocol and twelve of them had pre-existing or newly diagnosed diabetes. We have summarized other probable risk factors being considered such as immunosuppressed state, antiviral and Ayurvedic (Indian traditional) medications, oxygen therapy, with each of which we could not find a link of mucormycosis. We propose that COVID-19 itself through molecular mechanisms predisposes to mucormycosis, with other factors such as dysglycaemia providing a second hit.

scholarly journals The Second Wave of COVID-19: Clinical Pharmacy Services During a Field Hospital Operation

2021 ◽  
pp. 001857872110323
Author(s):  
Jessica Mazzone ◽  
Krysta Shannon ◽  
Richard Rovelli ◽  
Racha Kabbani ◽  
Angel Amaral ◽  
...  
Keyword(s):  
Clinical Pharmacy ◽  
The State ◽  
Pharmacy Services ◽  
Newly Diagnosed ◽  
Field Hospital ◽  
Clinical Role ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

The second wave of COVID-19 emerged in the late fall months in the state of Massachusetts and inadvertently caused a rise in the number of cases requiring hospitalization. With a field hospital previously opened in central Massachusetts during the Spring of 2020, the governor decided to reimplement the field hospital. Although operations were effectively accomplished during the first wave, the reimplementation of the field hospital came with its new set of challenges for operating a satellite pharmacy. Experiences gathered include new pharmacy operation workflows, the clinical role of pharmacy services, introduction of remdesivir treatment, and pharmacy involvement in newly diagnosed diabetes patients requiring insulin teaching. Pharmacy services were successful in adapting to the rapidly growing number in patients with a total of over 600 patients served in a course of 2 months.

Abstract #502: Newly Diagnosed Diabetes Mellitus Presenting as Chylomicronemia Syndrome an Uncommon Presentation of a Common Disease

2016 ◽  
Vol 22 ◽  
pp. 116
Author(s):  
Maha Sulieman ◽  
Delamo Isaac Bekele ◽  
Jennifer Marquita Carter ◽  
Rabia Cherqaoui ◽  
Vijaya Ganta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Common Disease ◽  
Newly Diagnosed ◽  
Uncommon Presentation ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

A Clinical Study of Microvascular Complications in Newly Diagnosed Diabetes Mellitus Patients

2011 ◽  
Vol 4 (2) ◽  
pp. 12-14
Author(s):  
Dr Yash Patel ◽  
◽  
Dr Ashay Shingare ◽  
Dr Gautam Kalita ◽  
Dr Vinaya Bhandari
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Study ◽  
Microvascular Complications ◽  
Newly Diagnosed ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes
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