scholarly journals Rhino-orbital mucormycosis related to COVID-19- A case series exploring risk factors

2021 ◽  
Author(s):  
Sushil Kumar Aggarwal ◽  
Upinder Kaur ◽  
Dolly Talda ◽  
Akshat Pandey ◽  
Sumit Jaiswal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Mechanisms ◽  
Common Factor ◽  
Case Series ◽  
Intracranial Extension ◽  
Management Protocol ◽  
Male Preponderance ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

Abstract There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycaemia due to diabetes present as a common comorbidity in these COVID-19 patients as well as indiscriminate steroid use has resulted in this surge. Here, we report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted at our center between mid-April and early June 2021. Out of the 13, the only common factor was COVID-19 at some time point before diagnosis of mucormycosis or coexistent with it. The cases showed a male preponderance and four of them showed intracranial extension of disease. Eleven of them had received steroids as part of COVID-19 management protocol and twelve of them had pre-existing or newly diagnosed diabetes. We have summarized other probable risk factors being considered such as immunosuppressed state, antiviral and Ayurvedic (Indian traditional) medications, oxygen therapy, with each of which we could not find a link of mucormycosis. We propose that COVID-19 itself through molecular mechanisms predisposes to mucormycosis, with other factors such as dysglycaemia providing a second hit.

scholarly journals Rhino-orbital mucormycosis related to COVID-19- A case series exploring risk factors

2021 ◽  
Author(s):  
Sushil Kumar Aggarwal ◽  
Upinder Kaur ◽  
Dolly Talda ◽  
Akshat Pandey ◽  
Sumit Jaiswal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Mechanisms ◽  
Common Factor ◽  
Case Series ◽  
Intracranial Extension ◽  
Management Protocol ◽  
Male Preponderance ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

Abstract There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycaemia due to diabetes present as a common comorbidity in these COVID-19 patients as well as indiscriminate steroid use has resulted in this surge. Here, we report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted at our center between mid-April and early June 2021. Out of the 13, the only common factor was COVID-19 at some time point before diagnosis of mucormycosis or coexistent with it. The cases showed a male preponderance and four of them showed intracranial extension of disease. Eleven of them had received steroids as part of COVID-19 management protocol and twelve of them had pre-existing or newly diagnosed diabetes. We have summarized other probable risk factors being considered such as immunosuppressed state, antiviral and Ayurvedic (Indian traditional) medications, oxygen therapy, with each of which we could not find a link of mucormycosis. We propose that COVID-19 itself through molecular mechanisms predisposes to mucormycosis, with other factors such as dysglycaemia providing a second hit.

scholarly journals Case Report: Rhino-orbital Mucormycosis Related to COVID-19: A Case Series Exploring Risk Factors

2021 ◽  
Author(s):  
Sushil Kumar Aggarwal ◽  
Upinder Kaur ◽  
Dolly Talda ◽  
Akshat Pandey ◽  
Sumit Jaiswal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Mechanisms ◽  
Case Series ◽  
Intracranial Extension ◽  
Newly Diagnosed ◽  
Steroid Use ◽  
Male Preponderance ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycemia resulting from diabetes which is a common comorbidity in COVID-19 patients, and indiscriminate steroid use has resulted in this surge. We report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted to our center between mid-April and early June 2021. The cases showed a male preponderance, two patients had loss of vision, and four of them showed intracranial extension of disease. Twelve patients had received steroids and 12 had preexisting or newly diagnosed diabetes, both steroid use and diabetes being the most common identified risk factors. Considering other possible risk factors, immunosuppressed state, antiviral or ayurvedic (Indian traditional) medications, and oxygen therapy were not associated with a definite risk of mucormycosis, because they were not present uniformly in the patients. We propose that COVID-19 itself, through molecular mechanisms, predisposes to mucormycosis, with other factors such as dysglycemia or steroid use increasing the risk.

scholarly journals The Second Wave of COVID-19: Clinical Pharmacy Services During a Field Hospital Operation

2021 ◽  
pp. 001857872110323
Author(s):  
Jessica Mazzone ◽  
Krysta Shannon ◽  
Richard Rovelli ◽  
Racha Kabbani ◽  
Angel Amaral ◽  
...  
Keyword(s):  
Clinical Pharmacy ◽  
The State ◽  
Pharmacy Services ◽  
Newly Diagnosed ◽  
Field Hospital ◽  
Clinical Role ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Second Wave

The second wave of COVID-19 emerged in the late fall months in the state of Massachusetts and inadvertently caused a rise in the number of cases requiring hospitalization. With a field hospital previously opened in central Massachusetts during the Spring of 2020, the governor decided to reimplement the field hospital. Although operations were effectively accomplished during the first wave, the reimplementation of the field hospital came with its new set of challenges for operating a satellite pharmacy. Experiences gathered include new pharmacy operation workflows, the clinical role of pharmacy services, introduction of remdesivir treatment, and pharmacy involvement in newly diagnosed diabetes patients requiring insulin teaching. Pharmacy services were successful in adapting to the rapidly growing number in patients with a total of over 600 patients served in a course of 2 months.

scholarly journals Covid associated orbital apex syndrome: Madras ENT Research Foundation experience

2021 ◽  
Vol 7 (9) ◽  
pp. 1513
Author(s):  
Manjunatha H. Anandappa ◽  
Sunil Mathews ◽  
Kiran Natarajan ◽  
Raghunandhan S. ◽  
Mohan Kameswaran
Keyword(s):  
Elderly Patients ◽  
Relevant Literature ◽  
Case Series ◽  
Healthy Individuals ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Timely Manner ◽  
Management Protocol ◽  
Life Threatening ◽  
Second Wave

<p class="abstract">The second wave of corona virus pandemic is currently raging through India since last few weeks. Since last year, COVID-19 has brought in a multitude of challenging manifestations in the ENT regions. One such rare and complex entity is OAS (orbital apex syndrome). This case series highlighted our experience in 2020 with managing two such cases of OAS associated with COVID-19 infection. Their clinical and radiological presentation was discussed and their management protocol was explained with references from relevant literature. Although elderly patients with co-morbidities were considered to have highest risk for COVID-19 associated neurologic and ophthalmic complications earlier, now it was found to affect younger healthy individuals as noted in our cases. Knowledge about such virulent complications of COVID-19 is essential for otolaryngologists, to manage this life-threatening entity in a timely manner.</p>

scholarly journals Sudden cardiac death among Iranian population: a two decades follow-up of Tehran lipid and glucose study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hossein Toreyhi ◽  
Samaneh Asgari ◽  
Davood Khalili ◽  
Mehdi Pishgahi ◽  
Fereidoun Azizi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Significant Risk ◽  
High Waist Circumference ◽  
Cox Proportional Hazard Models ◽  
Study Population ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

AbstractSudden cardiac death (SCD) is described as death within one hour, if observed, from the onset of symptoms, and within 24 h of being alive and well if not observe. Study population includes 3705 men and 4446 women, aged ≥ 30 years. Multivariable Cox proportional hazard models were used to determine the risk factors associated with SCD. After a median follow-up of 17.9 years, 244 SCD (165 in males) occurred. The age-standardized incidence rate (95% confidence intervals (CI)) of SCD was 2.3 (2.1–2.7) per 1000 person-year. Current smoking [Hazard ratio (HR): 2.43, 95% CI: 1.73–3.42], high waist circumference [1.49: 1.04–2.12], hypertension [1.39: 1.05–1.84], type 2 diabetes mellitus [2.78: 2.09–3.69], pulse rate ≥ 90 beats per/minute [1.72: 1.22–2.42] and prevalent cardiovascular disease [1.75: 1.26–2.45] were significant risk factors. The corresponding population attributed fractions (PAF) were 14.30, 16.58, 14.03, 19.60, 7.62, and 8.30, respectively. Being overweight [0.58: 0.40–0.83] and obese [0.61: 0.38–0.98] decreased the risk of SCD. After excluding known diabetes cases from our data analysis, the newly diagnosed diabetes still showed an HR of 2.0 (1.32–3.00) with a PAF of 7.15% in the full adjustment model. To deal with sudden death as a catastrophic outcome, multi-component strategies by policy health makers are suggested.

Abstract #502: Newly Diagnosed Diabetes Mellitus Presenting as Chylomicronemia Syndrome an Uncommon Presentation of a Common Disease

2016 ◽  
Vol 22 ◽  
pp. 116
Author(s):  
Maha Sulieman ◽  
Delamo Isaac Bekele ◽  
Jennifer Marquita Carter ◽  
Rabia Cherqaoui ◽  
Vijaya Ganta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Common Disease ◽  
Newly Diagnosed ◽  
Uncommon Presentation ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes
Sign in / Sign up

Export Citation Format

Share Document