This study aims to solve the problem of multi-sensor information fusion, which is a key issue in the multi-sensor system development. The main innovation of this study is to propose a novel multi-sensor information fusion algorithm based on back propagation neural network and Bayesian inference. In the proposed algorithm, a triple is defined to represent a probability space; thereafter, the Bayesian inference is used to estimate the posterior expectation. Finally, we construct a simulation environment to test the performance of the proposed algorithm. Experimental results demonstrate that the proposed algorithm can significantly enhance the accuracy of temperature detection after fusing the data obtained from different sensors.