The Impact of Intravitreal Ranibizumab Treatment on Outer Retinal Layer Thickness in Neovascular Age-related Macular Degeneration

Age-related macular degeneration (AMD) is a chronic and progressive disease of the central retina that causes vision loss in people over 50 years of age. With an understanding of the role of VEGF in AMD, intravitreal anti-VEGF agents are used as the most important therapeutic tool in the management of AMD. In this review we try to discuss intravitreal ranibizumab treatment and treatment regimens in wet (neovascular) age-related macular degeneration.

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Switching from Intravitreal Ranibizumab to Bevacizumab for Age-Related Macular Degeneration

ISRN Ophthalmology ◽

10.5402/2011/916789 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Kisaburo Yamada ◽

Kenichi Kimoto ◽

Hirofumi Kono ◽

Toshiaki Kubota

Keyword(s):

Macular Degeneration ◽

Intravitreal Bevacizumab ◽

Age Related Macular Degeneration ◽

Rank Test ◽

Intravitreal Ranibizumab ◽

Age Related ◽

Signed Rank ◽

Significant Difference ◽

Signed Rank Test ◽

Ranibizumab Treatment

Purpose. To report our experiences in patients with age-related macular degeneration (AMD) treated initially with intravitreal ranibizumab and then switched to bevacizumab. Methods. We retrospectively reviewed the records of 7 patients (7 eyes) who were treated with monthly injections of intravitreal ranibizumab and then switched to injections of bevacizumab (every 6 weeks) for six months. The best-corrected visual acuity measurements (BCVA) and optical coherence tomography (OCT) were performed at the baseline examination and then at each visit. The Wilcoxon signed-rank test was used for the statistical analysis. Results. Following three monthly ranibizumab treatments, there was no significant difference in the BCVA, while the foveal retinal thickness (FRT) significantly decreased (). Switching from ranibizumab to bevacizumab resulted in maintenance (57.2%) of the BCVA and a further decrease in the FRT () after 6 months. Conclusions. Switching to intravitreal bevacizumab may be effective in patients who wish to discontinue intravitreal ranibizumab treatment due to the high cost.

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Long term intravitreal ranibizumab treatment for exsudative age-related macular degeneration

Orvosi Hetilap ◽

10.1556/oh.2013.29729 ◽

2013 ◽

Vol 154 (45) ◽

pp. 1790-1797 ◽

Cited By ~ 1

Author(s):

Regina Lukács ◽

Miklós Resch ◽

András Papp ◽

Antal Szabó ◽

Ágnes Borbándy ◽

...

Keyword(s):

Macular Degeneration ◽

Retinal Thickness ◽

Age Related Macular Degeneration ◽

Central Retinal Thickness ◽

First Year ◽

Intravitreal Ranibizumab ◽

Age Related ◽

Pro Re Nata ◽

Ranibizumab Treatment

Introduction: The results of intravitreal ranibizumab treatment for exsudative age-related macular degeneration have been favourable until this time. Aim: To evaluate the two-year functional and anatomic results of intravitreal ranibizumab treatment. Method: 46 patients (age: 75±9.1 years) were included in a prospective single center study. Treatment regimen was the following: monthly 0.5 mg ranibizumab was administered in the first 3 months, and later as required (pro re nata). The change of best corrected visual acuity and central retinal thickness was followed. Results: The visus change at the end of the follow-up time was not statistically significant compared to baseline (p = 0.760) and the at the end of the first year (p = 0.154). Central retinal thickness decreased significantly compared to baseline (p = 0.000001), but the change was not statistically significant compared to the end of the first year (p = 0.875). Conclusions: Patients with neovascular macular degeneration treated with intravitreal ranibizumab using pro re nata regimen have stable visus for long term, and the exsudation could be reduced efficiently. Orv. Hetil., 154(45), 1790–1797.

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Factors Associated With the Response of Age-Related Macular Degeneration to Intravitreal Ranibizumab Treatment

American Journal of Ophthalmology ◽

10.1016/j.ajo.2012.01.010 ◽

2012 ◽

Vol 154 (1) ◽

pp. 125-136 ◽

Cited By ~ 69

Author(s):

Kenji Yamashiro ◽

Kaoruko Tomita ◽

Akitaka Tsujikawa ◽

Isao Nakata ◽

Yumiko Akagi-Kurashige ◽

...

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Intravitreal Ranibizumab ◽

Factors Associated ◽

Age Related ◽

Ranibizumab Treatment

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Correlation between Visual Functions and Retinal Morphology in Eyes with Early and Intermediate Age-Related Macular Degeneration

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17176379 ◽

2020 ◽

Vol 17 (17) ◽

pp. 6379

Author(s):

Rituparna Ghoshal ◽

Sharanjeet Sharanjeet-Kaur ◽

Norliza Mohamad Fadzil ◽

Haliza Abdul Mutalib ◽

Somnath Ghosh ◽

...

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Layer Thickness ◽

Reading Speed ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Morphological Alteration ◽

Retinal Layer ◽

Visual Functions ◽

Age Related

In early and intermediate age related macular degeneration (ARMD), visual acuity alone has failed to explain the complete variation of vision. The aim of the present study was to determine correlation between different visual functions and retinal morphology in eyes with early and intermediate ARMD. In this single center cross sectional study, patients diagnosed as early or intermediate ARMD in at least one eye were recruited. Visual functions measured were best- corrected distance visual acuity (DVA), near vision acuity (NVA), reading speed (RS), and contrast sensitivity (CS). Parameters such as thickness (RT) and volume (RV) of the retina, outer retinal layer thickness (ORLT) and volume (ORLV), outer nuclear layer thickness (ONLT) and volume (ONLV), retinal pigment epithelium layer-Bruch’s membrane complex thickness (RPET) and volume (RPEV) were assessed employing semi-auto segmentation method of Spectralis optical coherence tomography (OCT). Twenty-six eyes were evaluated. DVA, CS, and RS showed significantly good correlation with RPET, ONLT, and ONLV, whereas NVA showed good correlation with ONLV and RPET. The present study concluded that RS, CS, NVA, and DVA represent the morphological alteration in early stages and should be tested in clinical settings. ONLT, ONLV, and RPET morphological parameters can be employed as important biomarkers in diagnosis of early to intermediate ARMD.

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