scholarly journals Treatment Outcome and Mortality Among Geriatric Patients Diagnosed with Multiple-Drug Resistant Tuberculosis: A Comparative Analysis from a Tertiary Referral Center

2021 ◽  
Vol 59 (5) ◽  
pp. 377-380
Author(s):  
Seda Tural Onur ◽  
Mediha Gonenc Ortakoylu ◽  
Sinem Iliaz ◽  
Figen Alkan
Keyword(s):  
Treatment Outcome ◽  
Comparative Analysis ◽  
Geriatric Patients ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Tertiary Referral ◽  
Drug Resistant Tuberculosis ◽  
Tertiary Referral Center ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant

scholarly journals Strategies for Treating Latent Multiple-Drug Resistant Tuberculosis: A Decision Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30194 ◽  
Author(s):  
David P. Holland ◽  
Gillian D. Sanders ◽  
Carol D. Hamilton ◽  
Jason E. Stout
Keyword(s):  
Decision Analysis ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant

MULTIPLE DRUG–RESISTANT TUBERCULOSIS

1998 ◽  
Vol 12 (1) ◽  
pp. 157-172 ◽  
Author(s):  
Williamson Z. Bradford ◽  
Charles L. Daley
Keyword(s):  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant

scholarly journals Tuberculosis and Trimethoprim-Sulfamethoxazole

2009 ◽  
Vol 53 (11) ◽  
pp. 4789-4793 ◽  
Author(s):  
Pierre Forgacs ◽  
Nancy L. Wengenack ◽  
Leslie Hall ◽  
Sarah K. Zimmerman ◽  
Mark L. Silverman ◽  
...  
Keyword(s):  
Immunocompromised Patient ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Mycobacterium Kansasii ◽  
Drug Resistant Tuberculosis ◽  
Rapidly Growing Mycobacteria ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Antituberculous Drug ◽  
Widespread Belief

ABSTRACT The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunocompromised patient with tuberculosis who was initially treated with TMP-SMX without antituberculous drugs and defervesced on this treatment. An isolate of M. tuberculosis from this patient was found to be sensitive to TMP-SMX. We examined how frequently M. tuberculosis is sensitive to TMP-SMX. Isolates were tested for susceptibility to TMP-SMX on supplemented Middlebrook 7H10 plates. We found that 43 of 44 (98%) isolates of M. tuberculosis were susceptible to the combination of ≤1 μg/ml of TMP and 19 μg/ml of SMX (≤1/19 μg/ml). Thus, the vast majority of our M. tuberculosis isolates were susceptible to TMP-SMX at an MIC similar to that for Mycobacterium kansasii, Mycobacterium marinum, and sensitive rapidly growing mycobacteria, organisms successfully treated with TMP-SMX as part of the treatment regimen. It is possible that TMP-SMX may be useful in treating patients with multiple-drug-resistant and extended drug-resistant tuberculosis. We feel that a clinical trial looking at the effectiveness of TMP-SMX as an antituberculous drug is worthwhile.

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