scholarly journals Auditory steady-state response thresholds in infants and young children with auditory neuropathy spectrum disorder

2010 ◽  
Vol 53 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Hidenobu Taiji ◽  
Noriko Morimoto ◽  
Tatsuo Matsunaga
Keyword(s):  
Steady State ◽  
Young Children ◽  
Auditory Neuropathy ◽  
Spectrum Disorder ◽  
Steady State Response ◽  
Auditory Neuropathy Spectrum Disorder ◽  
State Response ◽  
Auditory Steady State Response ◽  
Response Thresholds ◽  
Infants And Young Children

scholarly journals Comparative Study of the Auditory Steady-State Response (ASSR) and Click Auditory Brainstem Evoked Response (ABR) Thresholds among Filipino Infants and Young Children

2009 ◽  
Vol 24 (1) ◽  
pp. 9-12
Author(s):  
Laurence Ian C. Tan ◽  
Maria Rina T. Reyes-Quintos ◽  
Maria Leah C. Tantoco ◽  
Charlotte M. Chiong
Keyword(s):  
Hearing Loss ◽  
Steady State ◽  
Young Children ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Steady State Response ◽  
State Response ◽  
Auditory Steady State Response ◽  
Brainstem Response ◽  
Infants And Young Children

Objective: To compare the results of auditory steady-state response (ASSR) and click auditory brainstem response (click ABR) among infants and young children tested at the Ear Unit of a Tertiary General Hospital.   Methods: Design: Cross-sectional Study Setting: Tertiary General Hospital Population: Within-subject comparisons of click auditory brainstem response (click ABR) thresholds and auditory steady-state response (ASSR) thresholds among 55 infants and young children, 2 months to 35 months of age referred to the Ear Unit for electrophysiologic hearing assessment. Results: Click ABR showed strong positive correlation to all frequencies and averages of ASSR. Highest correlation was noted with the average of 1-4 kHz ASSR results with Pearson r = 0.89 (Spearman r=0.80), the average of 2-4 kHz had strong positive correlation r = 0.88 (0.79). Correlation was consistently strong through all ASSR frequencies (0.5 kHz at r=0.86 (0.74), 1 kHz at r=0.88 (0.78), 2 kHz at r=0. 87 (0.79), 4 kHz at r=0.85 (0.76)). Average differences of click ABR and ASSR thresholds were 8.2±12.9dB at 0.5 kHz, 8.6±12.6dB at 1 kHz, 5.3±11.8dB at 2 kHz and 7.8±13.4dB at 4 kHz. Among patients with no demonstrable waveforms by click ABR with maximal click stimulus, a large percentage presented with ASSR thresholds. Of these, 80.5% (33 of 41) had measurable results at 0.5 kHz with an average of 107.3±11.1dB, 85.4% (35 of 41) at 1 kHz with an average of 110.5±11.8dB, 73.2% (30 of 41) at 2 kHz with an average of 111.2±11.1dB and 63.4% (26 of 41) at 4 kHz with and average of 112.2±8.21dB. Auditory steady-state response results were comparable to auditory brainstem response results in normal to severe hearing loss, and provided additional information necessary for complete audiologic assessment especially among patients with severe to profound hearing loss wherein click ABR showed no responses. Up to 85.4% of patients that would have been noted to have no waveforms by click ABR still demonstrated measurable thresholds by ASSR   Conclusion: Our study suggests that ASSR may be the best available tool for assessing children with severe to profound hearing loss, and is a comparably effective tool in overall hearing assessment for patients requiring electrophysiological testing. The advantages of ASSR over click ABR include: 1) detection of frequency-specific thresholds and; 2) the detection of hearing loss thresholds beyond the limits of click ABR.     Key words: Auditory Steady-State Response, ASSR, Auditory Brainstem-Evoked Response, ABR, Hearing Thresholds, Electrophysiologic Testing  

Validation of multi-channel auditory steady-state response in adults with sensorineural hearing loss

2008 ◽  
Vol 123 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Y-H Lin ◽  
P-R Chen ◽  
C-J Hsu ◽  
H-P Wu
Keyword(s):  
Hearing Loss ◽  
Steady State ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Sensorineural Hearing ◽  
Steady State Response ◽  
Academic Medical Centre ◽  
State Response ◽  
Auditory Steady State Response ◽  
Response Thresholds

AbstractObjective:For various medico-legal and financial reasons, some patients may clinically demonstrate an exaggerated hearing loss that varies in degree, nature and laterality. The purpose of this study was to evaluate whether multi-channel auditory steady-state response measurement can be used as an objective test of auditory thresholds in adults with sensorineural hearing loss.Study design and setting:This was a prospective, comparative, experimental research design study conducted in an academic medical centre. From January to June 2007, 142 subjects (284 ears) with varying degrees of sensorineural hearing loss were included. Four commonly used frequencies (500, 1000, 2000 and 4000 Hz) were evaluated. Both pure tone thresholds and multi-channel auditory steady-state response thresholds were obtained for each ear in all subjects. The correlation of auditory steady-state response thresholds and pure tone thresholds was assessed. The time taken for multi-channel auditory steady-state response testing was also recorded.Results:Results for multi-channel auditory steady-state response thresholds and pure tone thresholds were compared for each test frequency. A difference of less than 15 dB was found in 71 per cent of patients, while a difference of less than 20 dB was found in 83 per cent. Correlation between auditory steady-state response thresholds and pure tone thresholds, expressed as the correlation coefficient (r), was 0.89, 0.95, 0.96 and 0.97 at 500, 1000, 2000 and 4000 Hz, respectively. The strength of the relationship between auditory steady-state response thresholds and pure tone thresholds increased with increasing frequency and increasing degree of hearing loss. The recorded auditory steady-state response thresholds were used to calculate regression lines predicting pure tone threshold results. The mean estimated pure tone thresholds calculated from these regression lines were all within 10 dB of the actual recorded pure tone thresholds. The average multi-channel auditory steady-state response test duration was 42 minutes per patient.Conclusion:Measurement of multi-channel auditory steady-state response could be a powerful, convenient electro-physiological examination with which to objectively certify clinical hearing impairment in adults.

scholarly journals An integrative approach for pediatric auditory neuropathy spectrum disorders: revisiting etiologies and exploring the prognostic utility of auditory steady-state response

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pei-Hsuan Lin ◽  
Chuan-Jen Hsu ◽  
Yin-Hung Lin ◽  
Yi-Hsin Lin ◽  
Shu-Yu Yang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Steady State ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Auditory Neuropathy ◽  
Steady State Response ◽  
Distortion Product ◽  
State Response ◽  
Behavioral Thresholds ◽  
Auditory Steady State Response

Abstract Auditory neuropathy is an important entity in childhood sensorineural hearing loss. Due to diverse etiologies and clinical features, the management is often challenging. This study used an integrative patient-history, audiologic, genetic, and imaging-based approach to investigate the etiologies and audiologic features of 101 children with auditory neuropathy. Etiologically, 48 (47.5%), 16 (15.8%), 11 (10.9%), and 26 (25.7%) children were categorized as having acquired, genetic, cochlear nerve deficiency-related, and indefinite auditory neuropathy, respectively. The most common causes of acquired and genetic auditory neuropathy were prematurity and OTOF mutations, respectively. Patients with acquired auditory neuropathy presented hearing loss earlier (odds ratio, 10.2; 95% confidence interval, 2.2–47.4), whereas patients with genetic auditory neuropathy had higher presence rate of distortion product otoacoustic emissions (odds ratio, 10.7; 95% confidence interval, 1.3–85.4). In patients with different etiologies or pathological sites, moderate to strong correlations (Pearson’s r = 0.51–0.83) were observed between behavioral thresholds and auditory steady-state response thresholds. In conclusion, comprehensive assessments can provide etiological clues in ~75% of the children with auditory neuropathy. Different etiologies are associated with different audiologic features, and auditory steady-state responses might serve as an objective measure for estimating behavioral thresholds.

scholarly journals Measurement of Thresholds Using Auditory Steady-State Response and Cochlear Microphonics in Children with Auditory Neuropathy

2019 ◽  
Vol 30 (08) ◽  
pp. 672-676 ◽  
Author(s):  
Ping Lu ◽  
Yue Huang ◽  
Wen-Xia Chen ◽  
Wen Jiang ◽  
Ni-Yi Hua ◽  
...  
Keyword(s):  
Steady State ◽  
Normal Hearing ◽  
Auditory Neuropathy ◽  
High Signal ◽  
Steady State Response ◽  
Cochlear Microphonics ◽  
Behavioral Threshold ◽  
State Response ◽  
Auditory Steady State Response ◽  
The Difference

AbstractThe detection of precise hearing thresholds in infants and children with auditory neuropathy (AN) is challenging with current objective methods, especially in those younger than six months of age.The aim of this study was to compare the thresholds using auditory steady-state response (ASSR) and cochlear microphonics (CM) in children with AN and children with normal hearing.The thresholds of CM, ASSR, and visual reinforcement audiometry (VRA) tests were recorded; the ASSR and VRA frequencies used were 250, 500, 1000, 2000, and 4000 Hz.The participants in this study were 15 children with AN (27 ears) (1–7.6 years, median age 4.1 years) and ten children with normal hearing (20 ears) (1–8 years, median age four years).The thresholds of the three methods were compared, and histograms were used to represent frequency distributions of threshold differences obtained from the three methods.In children with normal hearing, the average CM thresholds (84.5 dB) were significantly higher than the VRA thresholds (10.0–10.8 dB); in children with AN, both CM and VRA responses were seen at high signal levels (88.9 dB and 70.6–103.4 dB, respectively). In normal children, the difference between mean VRA and ASSR thresholds ranged from 17.5 to 30.3 dB, which was significantly smaller than the difference seen between the mean CM and VRA thresholds (71.5–72.3 dB). The correlation between VRA and ASSR in children with normal hearing ranged from 0.38 to 0.48, whereas no such correlation was seen in children with AN at any frequency (0.03–0.19).Our results indicated that ASSR and CM were poor predictors of the conventional behavioral threshold in children with AN.

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