scholarly journals Optical method for verification of homogeneity of phantoms for calibration of magnetic resonance

2018 ◽  
Vol 10 (3) ◽  
pp. 82
Author(s):  
Anna Magdalena Sękowska ◽  
Aleksandra Kamińska ◽  
Agnieszka Sabisz

The primary purpose of this study was to develop a laboratory photonic set-up for characterisation of homogeneity of gel phantoms for calibration of a magnetic resonance. In this system optical coherence tomography allows the detection of micro- and macroscopic heterogeneities of a structure. The set-up was used to perform measurements of agar and agar-carrageenan gels, which are the basis for more complex phantoms for magnetic resonance calibration. Obtained results were compared with magnetic resonance tomography methods used to detect macroscopic spatial differences in composition and heterogeneities in phantoms. Full Text: PDF ReferencesPrice R. R. et al., Quality assurance methods and phantoms for magnetic resonance imaging: report of AAPM nuclear magnetic resonance Task Group No. 1., Med Phys. 1990 Mar-Apr;17(2):287-95. CrossRef Tofts P.S., QA: quality assurance, accuracy, precision and phantoms. Chapter 3 in Tofts P.S. (ed.) Quantitative MRI of the brain: measuring changes caused by disease. Chichester: John Wiley, 55-81. ISBN: 0-470-84721-2 CrossRef Wróbel M., Popov A., Bykov A., Tuchin V.V., Jędrzejewska-Szczerska M., Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering, Biomedical Optic Express, vol. 7(6), 2088-2094 (2016). CrossRef Feder I., Wróbel M., Duadi H., Jędrzejewska-Szczerska M., Fixler D., Experimental results of full scattering profile from finger tissue-like phantom, Biomedical Optic Express, vol. 7 (11), 4695-4701 (2016). CrossRef Wróbel M. S. et al., Use of optical skin phantoms for pre-clinical evaluation of laser efficiency for skin lesion therapy, Journal of Biomedical Optics, 20(8), 20(8):085003 (2015). CrossRef Wróbel M .S. et al., Multi-layered tissue head phantoms for noninvasive optical diagnostics, Journal of Innovative Optical Health Sciences, 8(3), 1541005-1÷1541005-10 (2015). CrossRef Hellerbach A, Schuster V, Jansen A, Sommer J., MRI Phantoms - Are There Alternatives to Agar?, Plos One, 2013;8(8), ARTN e70343. CrossRef Almazrouei N. K., Newton M. I., Dye E. R., Morris R. H., Novel food-safe spin-lattice relaxation time calibration samples for use in magnetic resonance sensor development, Proceedings 2018, 2, 122. CrossRef Ohno S. et al., Production of a Human-Tissue-Equivalent MRI Phantom: Optimization of Material Heating, Magn Reson Med Sci. 2008;7(3):131-40. CrossRef Choma M. A., SarunicM. V., Yang C., Izatt J. A., Sensitivity advantage of swept source and Fourier domain optical coherence tomography, Opt. Express 11, 2183-2189 (2003). CrossRef Strąkowski M. R., Głowacki M., Kamińska A., Sawczak M., Gold nanoparticles evaluation using functional optical coherence tomography, Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005336 (17 February 2017). CrossRef

2012 ◽  
Vol 37 (5) ◽  
pp. 872 ◽  
Author(s):  
Jason M. Tucker-Schwartz ◽  
Tu Hong ◽  
Daniel C. Colvin ◽  
Yaqiong Xu ◽  
Melissa C. Skala

2008 ◽  
Vol 85 (4) ◽  
pp. 1271-1277 ◽  
Author(s):  
Nicholas S. Burris ◽  
Emile N. Brown ◽  
Michael Grant ◽  
Zachary N. Kon ◽  
Marc Gibber ◽  
...  

Author(s):  
Harmony R. Reynolds ◽  
Akiko Maehara ◽  
Raymond Y. Kwong ◽  
Tara Sedlak ◽  
Jacqueline Saw ◽  
...  

Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 6-15% of MI and disproportionately affects women. Scientific statements recommend multi-modality imaging in MINOCA to define the underlying cause. We performed coronary optical coherence tomography (OCT) and cardiac magnetic resonance imaging (CMR) to assess mechanisms of MINOCA. Methods: In this prospective, multicenter, international, observational study, we enrolled women with a clinical diagnosis of MI. If invasive coronary angiography revealed <50% stenosis in all major arteries, multi-vessel OCT was performed, followed by CMR (cine imaging, late gadolinium enhancement, and T2-weighted imaging and/or T1 mapping). Angiography, OCT, and CMR were evaluated at blinded, independent core laboratories. Culprit lesions identified by OCT were classified as definite or possible. The CMR core laboratory identified ischemia-related and non-ischemic myocardial injury. Imaging results were combined to determine the mechanism of MINOCA, when possible. Results: Among 301 women enrolled at 16 sites, 170 were diagnosed with MINOCA, of whom 145 had adequate OCT image quality for analysis; 116 of these underwent CMR. A definite or possible culprit lesion was identified by OCT in 46.2% (67/145) of participants, most commonly plaque rupture, intra-plaque cavity or layered plaque. CMR was abnormal in 74.1% (86/116) of participants. An ischemic pattern of CMR abnormalities (infarction or myocardial edema in a coronary territory) was present in 53.4% of participants undergoing CMR (62/116). A non-ischemic pattern of CMR abnormalities (myocarditis, takotsubo syndrome or non-ischemic cardiomyopathy) was present in 20.7% (24/116). A cause of MINOCA was identified in 84.5% of the women with multi-modality imaging (98/116), higher than with OCT alone (p<0.001) or CMR alone (p=0.001). An ischemic etiology was identified in 63.8% of women with MINOCA (74/116), a non-ischemic etiology was identified in 20.7% (24/116), and no mechanism was identified in 15.5% (18/116). Conclusions: Multi-modality imaging with coronary OCT and CMR identified potential mechanisms in 84.5% of women with a diagnosis of MINOCA, three-quarters of which were ischemic and one-quarter of which were non-ischemic, alternate diagnoses to MI. Identification of the etiology of MINOCA is feasible and has the potential to guide medical therapy for secondary prevention. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT02905357


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