scholarly journals Automatic system for optical parameters measurements of biological tissues

2018 ◽  
Vol 10 (3) ◽  
pp. 91
Author(s):  
Paulina Listewnik ◽  
Adam Mazikowski
Keyword(s):  
Skin Diseases ◽  
Biomedical Optics ◽  
Biological Tissues ◽  
Optical Parameters ◽  
Modular Construction ◽  
Measurement Systems ◽  
Fundamental Properties ◽  
Tissue Phantoms ◽  
Measurement And Analysis ◽  
Homogeneous Tissue

In this paper a system allowing execution of automatic measurements of the optical parameters of scattering materials in a efficient and accurate manner is proposed and described. The system is designed especially for measurements of biological tissues including phantoms, which closely imitate optical characteristics of a real tissue. The system has modular construction and is based on ISEL system, luminance and color meter and a computer with worked out dedicated software and user interface. Performed measurements of scattering distribution characteristics for selected materials revealed good accuracy, confirmed by comparative measurements using well-known reference characteristics. Full Text: PDF ReferencesWróbel, M. S., Popov, A. P., Bykov, A. V., Kinnunen, M., Jedrzejewska-Szczerska, M., & Tuchin, V. V. (2015). Measurements of fundamental properties of homogeneous tissue phantoms. Journal of Biomedical Optics CrossRef Wróbel, M. S., Jedrzejewska-Szczerska, M., Galla, S., Piechowski, L., Sawczak, M., Popov, A. P., Cenian, A. (2015). Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy. Journal of Biomedical Optics. CrossRef Jędrzejewska-Szczerska, M., Wróbel, M. S., Galla, S., Popov, A. P., Bykov, A. V., Tuchin, V. V., & Cenian, A. (2015). Investigation of photothermolysis therapy of human skin diseases using optical phantoms. In Proceedings of SPIE - The International Society for Optical Engineering. CrossRef Brown A. M., et al.: Optical material characterization through BSDF measurement and analysis, Proc. of SPIE, Vol. 7792, 2010 CrossRef 4-Axis Controller: iMC-S8. Operating Instruction. ISEL Germany AG, 2012. DirectLink Konica Minolta, Inc. (2005-2013). Chroma meter CS-200. Datasheet. DirectLink Malacara D.: Color Vision and Colorimetry; Theory and Applications, SPIE Press, 2002. DirectLink A. Mazikowski, M. Trojanowski: Measurements of Spectral Spatial Distribution of Scattering Materials for Rear Projection Screens used in Virtual Reality Systems, Metrology and Measurement Systems, 20 (3), pp. 443 - 452, 2013 CrossRef

scholarly journals Multi-layered tissue head phantoms for noninvasive optical diagnostics

2015 ◽  
Vol 08 (03) ◽  
pp. 1541005 ◽  
Author(s):  
M. S. Wróbel ◽  
A. P. Popov ◽  
A. V. Bykov ◽  
M. Kinnunen ◽  
M. Jędrzejewska-Szczerska ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Optical Measurement ◽  
Human Head ◽  
Medical Diagnostics ◽  
Optical Parameters ◽  
Measurement Systems ◽  
Tissue Phantoms ◽  
Optical And Mechanical Properties

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient [Formula: see text] and absorption coefficient μa) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide ( ZnO ) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

scholarly journals Measurements of fundamental properties of homogeneous tissue phantoms

2015 ◽  
Vol 20 (4) ◽  
pp. 045004 ◽  
Author(s):  
Maciej S. Wróbel ◽  
Alexey P. Popov ◽  
Alexander V. Bykov ◽  
Matti Kinnunen ◽  
Malgorzata Jedrzejewska-Szczerska ◽  
...  
Keyword(s):  
Fundamental Properties ◽  
Tissue Phantoms ◽  
Homogeneous Tissue

scholarly journals Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador
Keyword(s):  
Optical Properties ◽  
3D Printing ◽  
Clinical Training ◽  
Three Dimensional ◽  
Biological Tissues ◽  
3D Bioprinting ◽  
Technology Intelligence ◽  
Biomedical Device ◽  
Tissue Phantoms ◽  
Scientific Papers

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.

Detection of inhomogeneity by the observation of the surface of the material simulating biological tissues

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Barbara Kmiecik ◽  
Jerzy Detyna
Keyword(s):  
Biological Tissues ◽  
Material Surface ◽  
Pathological State ◽  
Butadiene Rubber ◽  
Test Results ◽  
Nitrile Butadiene Rubber ◽  
Tissue Phantoms ◽  
Approximate Location ◽  
Heterogeneous Tissue

Abstract This paper presents a research which involves the observation of the movement of points presented on a material surface under the influence of mechanical extortion. Tests were performed using two 15 mm silicone layers, one of which contained 1 mm thick elements of nitrile-butadiene rubber. Analysed materials were structurally heterogeneous tissue phantoms. Test results that were obtained indicated that the developed method allows detecting inhomogeneity and its approximate location, what may be used in pathological state prevention.

A DIFFUSION–TRANSPORT HYBRID METHOD FOR ACCELERATING OPTICAL TOMOGRAPHY

2010 ◽  
Vol 03 (04) ◽  
pp. 293-305 ◽  
Author(s):  
HYUN KEOL KIM ◽  
ANDREAS H. HIELSCHER
Keyword(s):  
Hybrid Method ◽  
Light Propagation ◽  
Optical Tomography ◽  
Biological Tissues ◽  
Initial Guess ◽  
Computationally Efficient ◽  
Diffusion Transport ◽  
Tissue Phantoms ◽  
Hybrid Solver ◽  
Reconstruction Time

It is well acknowledged that the equation of radiative transfer (ERT) provides an accurate prediction of light propagation in biological tissues, while the diffusion approximation (DA) is of limited accuracy for the transport regime. However, ERT-based reconstruction codes require much longer computation times as compared to DA-based reconstruction codes. We introduce here a computationally efficient algorithm, called a diffusion–transport hybrid solver, that makes use of the DA- or low-order ERT-based inverse solution as an initial guess for the full ERT-based reconstruction solution. To evaluate the performance of this hybrid method, we present extensive studies involving numerical tissue phantoms and experimental data. As a result, we show that the hybrid method reduces the reconstruction time by a factor of up to 23, depending on the physical character of the problem.

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