scholarly journals Increased ambulatory arterial stiffness index and blood pressure load in normotensive obese patients

2021 ◽  
Vol 21 (3) ◽  
pp. 1185-1190
Author(s):  
Fatma Kaplan Efe ◽  
Mujgan Tek ◽  
Tobb Etu Hastanesi̇

Objectives: It has been shown that blood pressure (BP) values measured in obese subjects are higher than the individuals with normal weight, even in normotensive limits. However, data concerning the Ambulatory Arterial Stiffness Index (AASI) and blood pressure load in normotensive obese subjects is lacking. This study was aimed to compare the ambulatory arterial stiffness index and blood pressure load in normotensive obese and healthy controls. Methods: One hundred normotensive obese and one hundred normal weight subjects were included in this study. All sub- jects underwent 24-hour ambulatory blood pressure monitoring. Ambulatory arterial stiffness index was calculated from 24-hour ambulatory blood pressure monitoring records. Ambulatory arterial stiffness index was defined as one minus the regression slope of unedited 24-h diastolic on systolic blood pressures. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) load values were calculated from 24-hour ambulatory blood pressure monitoring analysis. Results: Ambulatory arterial stiffness index of the obese subjects was significantly higher than the healthy controls (0.48±0.2 vs. 0.33±0.11, p<0.001). 24-hours systolic blood pressure and diastolic blood pressure loads were significantly higher in obese subjects. Logistic regression analysis revealed that body mass index (BMI) was an independent predictor for an abnor- mal ambulatory arterial stiffness ındex (≥0.50) (OR: 1.137, 95% CI: 0.915-1.001, p=0.004). Conclusion: Blood pressure load and ambulatory arterial stiffness index are increased in normotensive obese patients. Moreover, body mass index is an independent predictor for an abnormal ambulatory arterial stiffness index. Our results indicate that obese subjects are at higher risk for future cardiovascular events despite normal office BP levels. Keywords: Ambulatory arterial stiffness index; blood pressure load; obesity; blood pressure.

2017 ◽  
Vol 14 (1) ◽  
pp. 9
Author(s):  
Camilo  Palencia-Tejedor ◽  
Ruth  Azuaje-González ◽  
Óscar  Barrios-Benedeti ◽  
José  Ayala-Hernández ◽  
Carlos  Oberto-Machado ◽  
...  

                                                                        RESUMOObjetivo:  analisar  a  relação  existente  entre  os  parâmetros  de  avaliação  da  monitorização  ambulatorial de pressão arterial (pressão arterial, variabilidade, pressão de pulso, carga e padrão)  e o índice ambulatorial de rigidez arterial, de um hospital de quarto nível na cidade de Caracas,  Venezuela. Materiais e Métodos: realizou-se um estudo observacional retrospectivo, com uma  amostra significativa de 179 pacientes registrados na base dados de monitorização ambulatorial de  pressão arterial, na consulta cardiometabólica de um hospital, no período compreendido entre junho  a dezembro de 2014. Resultados: analisaram-se as monitorizações ambulatoriais de pressão arterial  de 179 pacientes em 24 horas, com idade média de 55 ± 16 anos, dos quais o 36,3 % era de sexo  masculino e o 87,0 % feminino, com um índice ambulatorial de rigidez arterial médio de 0,43 ± 0,17 e se utilizou a correlação de Pearson, com a pressão de pulso r = 0,50 p <0,001, com a idade r =  0,42 p <0,001, a pressão arterial sistólica r = 0,24 p = 0,001, a carga r = 0,20 p = 0,007. Conclusão: encontrou-se correlação positiva entre o índice ambulatorial de rigidez arterial e os parâmetros  de avaliação do índice ambulatorial de rigidez arterial, evidenciando que a rigidez ambulatorial  arterial é uma medida fácil de obter, que tem boa relação com fatores de risco conhecidos e pode ser  contemplada como parâmetro de controle e seguimento cardiovascular.PALAVRAS-CHAVE: monitorização ambulatorial, pressão arterial, rigidez arterial.Relación entre parámetros del monitoreo ambulatorio de presión arterial y el índice de rigidez arterial ambulatorio                                                                        RESUMENObjetivo: analizar la relación existente entre los parámetros de evaluación del monitoreo ambulatorio  de presión arterial (presión arterial, variabilidad, presión de pulso, carga y patrón) y el índice de rigidez  arterial ambulatorio, de un hospital de cuarto nivel en la ciudad de Caracas, Venezuela. Materiales y Métodos: se realizó un estudio observacional retrospectivo, con una muestra significativa de 179  pacientes registrados en la base datos del monitoreo ambulatorio de presión arterial, en la consulta  cardio-metabólica de un hospital, en el periodo comprendido entre junio a diciembre de 2014.  Resultados: se analizaron los monitoreos ambulatorios de presión arterial de 179 pacientes en 24  horas, con edad promedio 55  ± 16 años, de los cuales  el 36,3 % era de sexo masculino y el 87,0  % femenino, con un índice de rigidez arterial ambulatorio promedio de 0,43 ± 0,17 y se utilizó la  correlación de Pearson, con la presión de pulso r = 0,50 p <0,001, con la edad r = 0,42 p <0,001,  la presión arterial sistólica r = 0,24 p = 0,001, la carga r = 0,20 p = 0,007. Conclusión: se encontró  correlación positiva entre el índice de rigidez arterial ambulatorio y los parámetros de evaluación del  índice de rigidez arterial ambulatorio, evidenciando que la rigidez arterial ambulatoria es una medida  fácil de obtener, que tiene buena relación con factores de riesgo conocidos y puede ser contemplada  como parámetro de control y seguimiento cardiovascular.    PALABRAS CLAVE: monitoreo ambulatorio, presión arterial, rigidez arterial. Relationship between parameters of ambulatory blood pressure monitoring and ambulatory arterial stiffness                                                                     ABSTRACTObjective: To analyze the existent relationship between the evaluation parameters of ambulatory  blood pressure monitoring (blood pressure, variability, pulse pressure, load and pattern) and the  ambulatory arterial stiffness index, from a level IV hospital in the city of Caracas, Venezuela. Materials and Methods: a retrospective observational study was performed, with a significant sample of 179  patients registered in the database of blood pressure monitoring, in the cardio metabolic consultation  unit of a hospital, in the period between June and December of 2014. Results: the blood pressure  monitoring of 179 patients were analyzed in 24 hours, with an average age of 55 ± 16 years , from  which 36.3% were male and 87,0% female, with an average of arterial stiffness index of 0,43 ±  0,17  and the Pearson’s correlations was used, with pulse pressure r = 0,50 p <0,001, with the age  r = 0,42  p <0,001, the systolic blood pressure  r = 0,24 p = 0,001, the load r = 0,20 p = 0,007. Conclusion: a positive correlation was found between the arterial stiffness index and the parameters of evaluation  of ambulatory arterial stiffness index, evidencing that the ambulatory arterial stiffness is an easy  measure to obtain, that it has a good relation with known risk factors, and can be contemplated as a  parameter of control and cardiovascular monitoring.KEYWORDS: monitoring  ambulatory, arterial pressure, vascular stiffness. 


2005 ◽  
Vol 20 (10) ◽  
pp. 1484-1486 ◽  
Author(s):  
Susan Koshy ◽  
Colin Macarthur ◽  
Sanjeev Luthra ◽  
Mukesh Gajaria ◽  
Denis Geary

2002 ◽  
Vol 36 (7-8) ◽  
pp. 1142-1149 ◽  
Author(s):  
Cindy D Stowe ◽  
Stephanie F Gardner ◽  
Charles C Gist ◽  
Eldon G Schulz ◽  
Thomas G Wells

OBJECTIVE: To determine whether cardiac indices are altered as assessed by 24-hour ambulatory blood pressure monitoring (ABPM) in male children receiving either chronic methylphenidate or dextroamphetamine/levoamphetamine (Adderall) therapy. METHODS: Boys 7–11 years old who were receiving methylphenidate or Adderall for a minimum of 2 months were asked to participate. Subjects wore ambulatory blood pressure monitors for 24-hour periods both off and on stimulant therapy. RESULTS: Subjects (n = 17; 8 methylphenidate, 9 Adderall) were well matched. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate differed between off and on stimulant therapy (p < 0.05). DBP load calculated from ABPM reference data was increased significantly (9.0% ± 5.6% on and 4.8% ± 4.5% off therapy; p < 0.05) while subjects were taking Adderall. There was a trend toward a greater elevation in blood pressure load during awake hours and a more pronounced decrease during the asleep hours for periods on compared with off-stimulant therapy. This trend resulted in significant (p < 0.05) nocturnal dipping on-stimulant phases compared with off-stimulant therapy for both SBP and DBP (Adderall) and SBP (methylphenidate). Two subjects (1 Adderall, 1 methylphenidate) met the criteria to be considered hypertensive based both on mean awake and 24-hour blood pressure load assessments during their on-treatment period. One additional subject receiving Adderall therapy met the criteria to be considered hypertensive based on blood pressure load criteria while off therapy only. Positive correlation coefficients (p < 0.05) were found when comparing stimulant dose (mg/kg) with the percent change of mean SBP, DBP, and heart rate between off and on therapy (r = 0.56, 0.61, and 0.58, respectively). CONCLUSIONS: These preliminary data suggest that blood pressure and heart rate appear to be altered in male patients while receiving stimulant therapy for attention-deficit hyperactivity disorder. Blood pressure and heart rate screening and monitoring during stimulant therapy to determine whether alterations become clinically significant is encouraged.


2017 ◽  
Vol 64 (4) ◽  
pp. 279-283
Author(s):  
Alexandru Minca ◽  
◽  
Mihai Comsa ◽  
Maria Mirabela Manea ◽  
Maria Daniela Tanasescu ◽  
...  

Chronic kidney disease (CKD) affects approximately two million people (in a population of 20 million) in Romania. Hypertension is often associated with CKD and both (hypertension and CKD) are risk factors for cardiovascular (CV) events. Ambulatory blood pressure monitoring (ABPM) is increasingly used all around the world for the diagnosis and monitoring of BP (blood pressure) because it is proven that the ABPM is superior to office BP measurements in evaluating patients with hypertension, with or without CKD. Reduced nocturnal BP fall (non-dipping or reverse-dipping patterns) is associated with target organ damage, especially kidney disease and the proportion of non-dippers and reverse-dippers patients increases progressively with the reduction of glomerular filtration rate (GFR). Another ABPM parameter, ambulatory arterial stiffness index (AASI), is an index which was recently proposed for the evaluation of arterial stiffness (a better tool than PP). It has prognostic value for cardiac death and stroke and several studies have showed that is negatively related to eGFR and is positively related to albuminuria. Hyperbaric area index (HBI) might be considered a novel sensitive marker [independent of patterns of NBPC (nocturnal BP change)] for the reduction of kidney function. These facts suggest that ABPM offers multiple useful data with impact, not only in future CV and renal outcomes assessment, but also in the treatment and management of hypertensive patients with CKD.


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