scholarly journals Gastric Acid Secretion, Mucus Concentration and Ulceration Following Orogastic Feeding of Cannabis Sativa to Albino Wistar Rats

2012 ◽  
Vol 10 (1-2) ◽  
Author(s):  
AO Obembe ◽  
AO Aya ◽  
OO Okwari
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Wistar Rats ◽  
Cannabis Sativa

Evaluation of Long Term Alcohol Consumption on Gastric Acid Secretion and the Histomorphometry of the Stomach in Adult Male Wistar Rats

2016 ◽  
Vol 4 (5) ◽  
pp. 7
Author(s):  
Ese C. Adegor ◽  
Anthony E. Ojieh ◽  
Ovocity Eghworo ◽  
Lawrence O. Ewhre ◽  
Tarela M. E. Daubry ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Adult Male ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Dihydroquercetin (taxifolin) attenuates dexamethasone activity on prostaglandin E-2 but potentiates thromboxane-A2 action in gastric acid secretion in wistar rats

2020 ◽  
Vol 13 (3) ◽  
pp. 181-188
Author(s):  
Etah Etah Nkanu
Keyword(s):  
Body Weight ◽  
Prostaglandin E2 ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Wistar Rats ◽  
Acid Output ◽  
Thromboxane A2 ◽  
Mucus Secretion ◽  
Gastric Acid Output

The activity of dexamethasone and taxifolin {(2R, 3R)-2-(3, 4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one}supplementation on prostaglandin E2 and thromboxane A2 in gastric acid secretion and anti-ulcer was studied. Twenty male Wistar rats (180g-200g body weight) were used. The rats were randomly selected into four groups containing 5 rats each. Group 1 was the control group fed on normal rat feed. Group 2 received 3mg/kg of Dexamethasone (intraperitoneally) at one day interval. Group 3 received 3mg/kg of Dex. intraperitoneally and 1mg/kg body weight of taxifolin orally while group 4 received 1mg/kg body weight of taxifolin. At the end of 6 weeks, basal and peak gastric acid output was measured by continuous perfusion of rats stomach under anaesthesia with normal saline at the rate of 1ml/min. Gastric acid, mucus secretion, ulcer index, PGE-2 and thromboxane A2 activity were determined according to standard procedures. Results showed a significantly (p<.05) decreased prostaglandin and mucus secretion level and a raised thromboxane concentrations and gastric acid output in dexamethasone administration. Taxifolin significantly (p<.05) lowered thromboxane A2 concentration in Dex treatment while increasing the prostaglandin E2 level. We conclude that Taxifolin decreases dexamethasone- induced gastric acid secretion, increases prostaglandin activity but reduces thromboxane concentration.

Effect of Cannabis sativa extract on gastric acid secretion, oxidative stress and gastric mucosal integrity in rats

2015 ◽  
Vol 24 (6) ◽  
pp. 1417-1434 ◽  
Author(s):  
Omar M. E. Abdel-Salam ◽  
Rania Abdallah Ali Salama ◽  
Ezz-Eddin El-Denshary ◽  
Amany Ameen Sleem ◽  
Marawa El-Sayed El-Shamarka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Cannabis Sativa ◽  
Mucosal Integrity

Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Taofeek O. Usman ◽  
Lawrence A. Olatunji ◽  
Abdul Rasak A. Alada
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Wistar Rats ◽  
Saline Control ◽  
Control Group ◽  
High Blood Glucose ◽  
High Blood Glucose Level ◽  
Perfusion Apparatus ◽  
Male Wistar Rats

AbstractStudies have shown that the hyperglycemic state induced by intravenous glucagon or glucose infusion may lead to inhibition of gastric acid secretion through the inhibition of gastric vagus activity. Histamine is a well-known mammalian acid secretagogue and it stimulates acid secretion through HMale Wistar rats weighing between 200 and 250 g were divided into three groups that received an intravenous infusion of normal saline (control group), glucose (hyperglycemic group), or insulin (hypoglycemic group) followed by injection of histamine to stimulate acid secretion. The oesophageal and duodenal ends of the rats’ stomach were cannulated with polythene tubing and the stomach was perfused at room temperature using a Langendoff perfusion apparatus. The effluent was collected in aliquots over 10 min per sample and its pH was measured.There was a significant (p<0.05) decrease in acid secretion following histamine injection in the hyperglycemic rats, while histamine injection led to an increase (p<0.05) in acid secretion in the hypoglycemic rats.These results show that hyperglycemic state would result in attenuated histamine-stimulated gastric acid secretion, while hypoglycemic state would lead to increased histamine-stimulated gastric acid secretion.

Eleveted serum gastrin level cannot maintain basal and stimulated gastric acid secretion in histamine deficient transgenic mice

2001 ◽  
Vol 120 (5) ◽  
pp. A180-A180
Author(s):  
B HUNYADY ◽  
A ZOLYOMI ◽  
J CZIMMER ◽  
G MOZSIK ◽  
E BUZAS ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Serum Gastrin ◽  
Gastrin Level ◽  
Serum Gastrin Level

Evaluation of Mechanisms Involved in Gastric Acid Secretion of Pylorus-Ligated Rats

1958 ◽  
Vol 35 (3) ◽  
pp. 309-311 ◽  
Author(s):  
Thomas W. Jones ◽  
Henry N. Harkins
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid
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