scholarly journals Anti-oxidative Effect of Ligustrazine on Treatment and Prevention of Atherosclerosis

2014 ◽  
Vol 12 (6) ◽  
pp. 949 ◽  
Author(s):  
GD Huang ◽  
J Mao ◽  
ZW Ji
Keyword(s):  
Treatment And Prevention ◽  
Prevention Of Atherosclerosis ◽  
Oxidative Effect

scholarly journals Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis

2020 ◽  
Vol 21 (8) ◽  
pp. 2703 ◽  
Author(s):  
Tommaso Gori
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Plaque Rupture ◽  
Nitric Oxide Donors ◽  
New Class ◽  
Amyl Nitrite ◽  
Treatment And Prevention ◽  
The Subject ◽  
Prevention Of Atherosclerosis ◽  
Nitric Oxide Pathway

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been the subject of a number of pharmacological approaches, particularly since when this elusive mediator was identified as one of the most important modulators of vascular homeostasis beyond vasomotion, including platelet function, inflammation, and atherogenesis. While having potent antianginal and antiischemic properties, however, nitric oxide donors are also not devoid of side effects, including the induction of tolerance, and, as shown in the last decade, of oxidative stress and endothelial dysfunction. In turn, endothelial dysfunction is itself felt to be involved in all stages of atherogenesis, from the development of fatty streaks to plaque rupture and thrombosis. In the present review, we summarize the agents that act on the nitric oxide pathway, with a particular focus on their potentially beneficial antiatherosclerotic and unwanted pro-atherosclerotic effects.

scholarly journals PROMISING AREAS OF NONINVASIVE DIAGNOSTICS, CONSERVATIVE TREATMENT AND PREVENTION OF ATHEROSCLEROSIS

2020 ◽  
Vol 13 (6) ◽  
pp. 43-49
Author(s):  
RENAT G. FATYKHOV ◽  
◽  
GRIGORY A. FADEEV ◽  
NIKOLAY A. TSIBULKIN ◽  
OLGA YU. MIKHOPAROVA ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Noninvasive Diagnostics ◽  
Treatment And Prevention ◽  
Prevention Of Atherosclerosis

Physical Activity and Atherosclerosis: Which Animal Model?

2004 ◽  
Vol 29 (5) ◽  
pp. 657-683 ◽  
Author(s):  
James R. Turk ◽  
M. Harold Laughlin
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Animal Models ◽  
Secondary Prevention ◽  
Progressive Disease ◽  
Clinical Signs ◽  
Epidemiologic Studies ◽  
Treatment And Prevention ◽  
Cardiovascular Morbidity And Mortality ◽  
Prevention Of Atherosclerosis

Atherosclerosis is a progressive disease that is the most important single contributor to human cardiovascular morbidity and mortality. Epidemiologic studies show that physical activity, or routine exercise, reduces the risk of developing cardiovascular disease. The mechanisms through which exercise may function in primary or secondary prevention of atherosclerosis remain largely to be established. Most studies in humans are performed after the onset of clinical signs when disease is well advanced and the prescription of exercise is based on empirical evidence of benefit in secondary prevention. Animal models permit the study of the initiation and progression of preclinical stages of atherosclerosis. In order to provide information relevant to treatment and prevention, these models should mimic human disease and interactions of physical activity with disease processes as closely as possible. The purpose of this review is to compare animal models of atherosclerosis and to summarize the available data in those models in regard to the effects of exercise. Key words: hypercholesterolemia, exercise, pathology, porcine

Engineered nanoparticles for the detection, treatment and prevention of atherosclerosis: how close are we?

2017 ◽  
Vol 22 (9) ◽  
pp. 1438-1446 ◽  
Author(s):  
Luong T.H. Nguyen ◽  
Aristo Muktabar ◽  
Jinkai Tang ◽  
Vinayak P. Dravid ◽  
C. Shad Thaxton ◽  
...  
Keyword(s):  
Engineered Nanoparticles ◽  
Treatment And Prevention ◽  
Prevention Of Atherosclerosis
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