scholarly journals PROMISING AREAS OF NONINVASIVE DIAGNOSTICS, CONSERVATIVE TREATMENT AND PREVENTION OF ATHEROSCLEROSIS

2020 ◽  
Vol 13 (6) ◽  
pp. 43-49
Author(s):  
RENAT G. FATYKHOV ◽  
◽  
GRIGORY A. FADEEV ◽  
NIKOLAY A. TSIBULKIN ◽  
OLGA YU. MIKHOPAROVA ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Noninvasive Diagnostics ◽  
Treatment And Prevention ◽  
Prevention Of Atherosclerosis

scholarly journals Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis

2020 ◽  
Vol 21 (8) ◽  
pp. 2703 ◽  
Author(s):  
Tommaso Gori
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Plaque Rupture ◽  
Nitric Oxide Donors ◽  
New Class ◽  
Amyl Nitrite ◽  
Treatment And Prevention ◽  
The Subject ◽  
Prevention Of Atherosclerosis ◽  
Nitric Oxide Pathway

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been the subject of a number of pharmacological approaches, particularly since when this elusive mediator was identified as one of the most important modulators of vascular homeostasis beyond vasomotion, including platelet function, inflammation, and atherogenesis. While having potent antianginal and antiischemic properties, however, nitric oxide donors are also not devoid of side effects, including the induction of tolerance, and, as shown in the last decade, of oxidative stress and endothelial dysfunction. In turn, endothelial dysfunction is itself felt to be involved in all stages of atherogenesis, from the development of fatty streaks to plaque rupture and thrombosis. In the present review, we summarize the agents that act on the nitric oxide pathway, with a particular focus on their potentially beneficial antiatherosclerotic and unwanted pro-atherosclerotic effects.

scholarly journals Conservative treatment of the longitudinal flatfeet in children

2021 ◽  
Vol 11 (7) ◽  
pp. 298-309
Author(s):  
O. Shulga
Keyword(s):  
Conservative Treatment ◽  
Muscle Tone ◽  
Clinical Manifestations ◽  
Physiological Effect ◽  
Traditional Methods ◽  
Treatment And Prevention ◽  
Serial Casting ◽  
Long Term Result ◽  
Two Stages ◽  
Severity Degree

Introduction. A significant percentage of the musculoskeletal system pathology in children is currently fall on the foot pathology – longitudinal flatfeet, which is not only a medical, but also a social problem. The incidence of this pathology is up to 58% of the total orthopedic foot pathology. Traditional methods of treatment and prevention of mild (I– II severity) longitudinal flatfeet (LF), which are known today (massage, physiotherapy exercises, the use of orthopedic devices, electromyostimulation) do not give a significant effect and a stable, long-term result. This makes us look for more effective methods of conservative treatment of LF of the I– II severity degree, which have a pathogenic orientation and physiological effect. Purpose of the work: to develop the most effective algorithm for the complex conservative treatment of LF, depending on the severity, hemodynamic disorders, deformity options, foot rigidity. Materials and methods. Conservative treatment was carried out in 62 patients aged 10– 18 years with LF of the I– II severity degree. Depending on the clinical manifestations and examination results, the treatment was carried out in two stages. At the first stage, serial casting was used (in the presence of concomitant deformations – silicone pelottes were used). Results. The results of the two-stage conservative treatment of LF demonstrate the effectiveness of serial casting in combination with the use of silicone pelottes and biostimulators in comparison with traditional methods of foot correction. Conclusions. Algorithms for conservative treatment of LF were developed, depending on the severity, nature of the deformity, hemodynamic disorders and muscle tone of the lower leg and foot.

scholarly journals Microbiological rationale for the use of Abigel-gel in conservative treatment inflammatory periodontal diseases

2020 ◽  
Vol 103 (4) ◽  
pp. 8-12
Author(s):  
O. Lyubchenko ◽  
◽  
I. Veligorya ◽  
S. Polyakova ◽  
O. Ivanov ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Staphylococcus Epidermidis ◽  
Reference Strain ◽  
Periodontal Diseases ◽  
Standard Test ◽  
Gram Negative Bacteria ◽  
Antifungal Effect ◽  
Treatment And Prevention ◽  
Taxonomic Groups ◽  
Test Cultures

A comparative assessment of the antamicrobial properties of the gel herbal preparation Abigel was made; the comparison group consisted of Fitoron and President-gel with chlorhesidine. The studies were carried out using standard test cultures of gram-positive and gram-negative bacteria belonging to different taxonomic groups: Staphylococcus aureus ATCC 25923, Esсherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Bacillus subtilis ATCC6633, Proteus vulgaris ATCC 4636. The antifungal effect of the sample was investigated on the reference strain Candida albicans ATCC 885-653 (4, 5, 6). Also used clinical museum strains (Staphylococcus epidermidis, Enterococcus faecalis, Haemophillus influenzae, Streptococcus pyogenes, Streptococcusmutans, Neisseria sp). President gel with chlorhexidine, Fitoron and Abigel gel have pronounced anti-microbial properties in relation to the investigated test cultures of microorganisms. Abigel is an effective method of vibor in the conservative treatment of inflammatory periodontal diseases. The method of treatment and prevention of inflammatory periodontal diseases with the use of Abigel is quite effective and justified in complex treatment, and as an independent method.

Physical Activity and Atherosclerosis: Which Animal Model?

2004 ◽  
Vol 29 (5) ◽  
pp. 657-683 ◽  
Author(s):  
James R. Turk ◽  
M. Harold Laughlin
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Animal Models ◽  
Secondary Prevention ◽  
Progressive Disease ◽  
Clinical Signs ◽  
Epidemiologic Studies ◽  
Treatment And Prevention ◽  
Cardiovascular Morbidity And Mortality ◽  
Prevention Of Atherosclerosis

Atherosclerosis is a progressive disease that is the most important single contributor to human cardiovascular morbidity and mortality. Epidemiologic studies show that physical activity, or routine exercise, reduces the risk of developing cardiovascular disease. The mechanisms through which exercise may function in primary or secondary prevention of atherosclerosis remain largely to be established. Most studies in humans are performed after the onset of clinical signs when disease is well advanced and the prescription of exercise is based on empirical evidence of benefit in secondary prevention. Animal models permit the study of the initiation and progression of preclinical stages of atherosclerosis. In order to provide information relevant to treatment and prevention, these models should mimic human disease and interactions of physical activity with disease processes as closely as possible. The purpose of this review is to compare animal models of atherosclerosis and to summarize the available data in those models in regard to the effects of exercise. Key words: hypercholesterolemia, exercise, pathology, porcine

Engineered nanoparticles for the detection, treatment and prevention of atherosclerosis: how close are we?

2017 ◽  
Vol 22 (9) ◽  
pp. 1438-1446 ◽  
Author(s):  
Luong T.H. Nguyen ◽  
Aristo Muktabar ◽  
Jinkai Tang ◽  
Vinayak P. Dravid ◽  
C. Shad Thaxton ◽  
...  
Keyword(s):  
Engineered Nanoparticles ◽  
Treatment And Prevention ◽  
Prevention Of Atherosclerosis
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