Effect of two types of anesthesia on postoperative recovery of patients with gastric cancer and changes in the levels of their T lymphocyte subsets

Objectives: To evaluate the clinical efficacy of immunotherapy combined with chemotherapy in patients with advanced gastric cancer and its effect on nutritional status and changes of peripheral blood T lymphocyte subsets. Methods: Sixty patients with locally advanced gastric cancer who were admitted by Affiliated Hospital of Hebei University from March 2020 to February 2021 were enrolled and randomly divided into two groups, with 30 cases in each group. The control group was treated with FOLFOX4 chemotherapy, while the experimental group was additively treated with cindilizumab on the basis of control group. The incidence of adverse reactions, clinical efficacy, improvement of nutritional and physical status, and changes in the levels of T lymphocyte subgroups in the two groups were compared and analyzed. Results: The total effective rate was 70% in the experimental group, which was better than 43.3% of the control group (p=0.04). The improvement rate of performance status (ECOG) score and nutritional indicators in the experimental group was significantly better than that in the control group (p<0.05). Moreover, the indicators of CD3+, CD4+, CD4+/CD8+ in the experimental group were significantly higher than those in the control group after treatment, with statistically significant differences (CD3+, p=0.01; CD4 +, p=0.02; CD4+/CD8+, p=0.01). Conclusion: Immunotherapy combined with chemotherapy has a significant effect on locally advanced gastric cancer patients, with significant improvement in physical strength and nutritional status, significant improvement in T lymphocyte function, and no obvious adverse reactions. It is worth promoting in clinical application. doi: https://doi.org/10.12669/pjms.37.7.4347 How to cite this:Li W, Jiao J, Wang Z, Wei Y, Zhang Y. Clinical efficacy of immunotherapy combined with chemotherapy in patients with advanced gastric cancer, its effect on nutritional status and Changes of peripheral blood T lymphocyte subsets. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4347 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Selective depression of T-lymphocyte subsets in gastric cancer patients: An implication of immunotherapy

Journal of Surgical Oncology ◽

10.1002/jso.2930550307 ◽

1994 ◽

Vol 55 (3) ◽

pp. 165-169 ◽

Cited By ~ 14

Author(s):

Wei-Jei Lee ◽

King-Jen Chang ◽

Chue-Shue Lee ◽

Kai-Mo Chen

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

T Lymphocyte ◽

Lymphocyte Subsets ◽

T Lymphocyte Subsets ◽

Gastric Cancer Patients

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STUDY OF T-LYMPHOCYTE SUBSETS AND INTERLEUKIN-2 IN GASTRIC CANCER

The KITAKANTO Medical Journal ◽

10.2974/kmj1951.44.43 ◽

1994 ◽

Vol 44 (1) ◽

pp. 43-50

Author(s):

Masaru Izumi ◽

Susumu Owada ◽

Yasuo Morishita

Keyword(s):

Gastric Cancer ◽

T Lymphocyte ◽

Lymphocyte Subsets ◽

Interleukin 2 ◽

T Lymphocyte Subsets

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T-Lymphocyte Subsets in Patients with AJCC Stage III Gastric Cancer during Postoperative Adjuvant Chemotherapy

Scandinavian Journal of Surgery ◽

10.1177/145749690209100207 ◽

2002 ◽

Vol 91 (2) ◽

pp. 172-177 ◽

Cited By ~ 5

Author(s):

M. Y. Cho ◽

Y. G. Joh ◽

N. R. Kim ◽

S. I. Jung ◽

J. W. Bae ◽

...

Keyword(s):

Gastric Cancer ◽

T Cell ◽

Adjuvant Chemotherapy ◽

T Lymphocyte ◽

Lymphocyte Subsets ◽

Stage Iii ◽

Postoperative Adjuvant Chemotherapy ◽

T Lymphocyte Subsets ◽

Ajcc Stage ◽

Recurrence Group

Background and Aims: Advanced neoplastic diseases alter the immune response in cancer patients. The aim of this study was to evaluate the changes of T-lymphocyte subsets during postoperative adjuvant chemotherapy, and the relationship between T-lymphocyte subsets and tumor recurrence in AJCC stage III gastric cancers. Material and Methods: Analysis of T-lymphocyte subsets was performed in 39 patients with stage III gastric adenocarcinoma who had undergone a curative gastric resection and postoperative chemotherapy. Circulating T-lymphocyte subsets were measured on venous blood by using flow cytometry and monoclonal antibodies on preoperative day 1, and postoperative months 1, 3, and 6. Results: The 5-year disease-free survival rates of patients with stage 3a and 3b gastric cancer were 57.1 % and 33.3 %, respectively (p = 0.06). Values of CD3+ and CD4+ T-cells, and CD4+/CD8+ ratios were consistently lower in the recurrence group throughout the observation period. CD4+ T-cell counts were significantly lower in the recurrence group on preoperative day 1, and postoperative months 1 and 6. However, most values of the T-lymphocyte subsets showed no statistically significant difference when comparing the stage 3a and 3b disease patient groups. Conclusions: The results of this study suggest that immunosuppression associated with CD3+ and CD4+ T-cell depression is a risk factor for postoperative recurrence in patients with stage III gastric cancer.

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