Effect of moxibustion on T lymphocyte subsets in peripheral blood of rats with gastric cancer

2019 ◽  
Vol 17 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Jing Tan ◽  
Ren-da Yang ◽  
Huan Zhao ◽  
Zhuo-jun Peng ◽  
Li-zhi Ouyang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets

scholarly journals Analysis of Peripheral Blood T-lymphocyte Subsets in Patients with Gastric Cancer

1985 ◽  
Vol 8 (6) ◽  
pp. 329-335
Author(s):  
Shinji Togoh ◽  
Kiyoshi Nishiyama ◽  
Shouichi Kunimatsu ◽  
Shunsuke Kobayashi ◽  
Hiroshi Ehara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets

scholarly journals Clinical efficacy of immunotherapy combined with chemotherapy in patients with advanced gastric cancer, its effect on nutritional status and Changes of peripheral blood T lymphocyte subsets

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Wen-wen Li ◽  
Jin Jiao ◽  
Zhi-yu Wang ◽  
Ya-ning Wei ◽  
Yuan-fang Zhang
Keyword(s):  
Gastric Cancer ◽  
Nutritional Status ◽  
Advanced Gastric Cancer ◽  
Clinical Efficacy ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Control Group ◽  
T Lymphocyte Subsets ◽  
Experimental Group

Objectives: To evaluate the clinical efficacy of immunotherapy combined with chemotherapy in patients with advanced gastric cancer and its effect on nutritional status and changes of peripheral blood T lymphocyte subsets. Methods: Sixty patients with locally advanced gastric cancer who were admitted by Affiliated Hospital of Hebei University from March 2020 to February 2021 were enrolled and randomly divided into two groups, with 30 cases in each group. The control group was treated with FOLFOX4 chemotherapy, while the experimental group was additively treated with cindilizumab on the basis of control group. The incidence of adverse reactions, clinical efficacy, improvement of nutritional and physical status, and changes in the levels of T lymphocyte subgroups in the two groups were compared and analyzed. Results: The total effective rate was 70% in the experimental group, which was better than 43.3% of the control group (p=0.04). The improvement rate of performance status (ECOG) score and nutritional indicators in the experimental group was significantly better than that in the control group (p<0.05). Moreover, the indicators of CD3+, CD4+, CD4+/CD8+ in the experimental group were significantly higher than those in the control group after treatment, with statistically significant differences (CD3+, p=0.01; CD4 +, p=0.02; CD4+/CD8+, p=0.01). Conclusion: Immunotherapy combined with chemotherapy has a significant effect on locally advanced gastric cancer patients, with significant improvement in physical strength and nutritional status, significant improvement in T lymphocyte function, and no obvious adverse reactions. It is worth promoting in clinical application. doi: https://doi.org/10.12669/pjms.37.7.4347 How to cite this:Li W, Jiao J, Wang Z, Wei Y, Zhang Y. Clinical efficacy of immunotherapy combined with chemotherapy in patients with advanced gastric cancer, its effect on nutritional status and Changes of peripheral blood T lymphocyte subsets. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4347 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios

2021 ◽  
Vol 35 ◽  
pp. 205873842110393
Author(s):  
Dan Zhang ◽  
Fan Zhang ◽  
Meiling Liu ◽  
Mingchao Zhang ◽  
Jiong Zhang ◽  
...  
Keyword(s):  
Disease Activity ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Activity Index ◽  
Renal Tissue ◽  
Renal Outcome ◽  
T Lymphocyte Subsets ◽  
Significant Difference ◽  
Renal Prognosis

Introduction Cell-mediated autoimmunity, especially the autoreactivity of T cells, is known to underlie the initiation of anti-glomerular basement membrane disease. However, the T lymphocyte subsets that determine the disease activity, renal fibrosis, and prognosis of anti-GBM disease have not been clearly elucidated. Methods The T lymphocyte subsets (CD4+ and CD8+) were examined on peripheral blood and renal biopsy tissues from 65 patients with biopsy proven anti-GBM disease. Patients were divided into the high ratio group and low ratio group according to the cutoff values in the receiver operating characteristic curve analysis. The correlations of T lymphocyte subsets with clinical, pathological data, and renal outcome were analyzed. Results By the end of follow-up, 45 patients (69.2%) developed end-stage renal disease (ESRD). In peripheral blood, the CD4+/CD8+ ratio showed a predictive ability with a sensitivity and specificity of 91.3% and 52.9%, respectively, which gave rise to a cutoff value of 0.89. There was a significant difference in the activity index between these two groups (3.91 ± 1.38 vs. 2.89 ± 1.13, p = 0.007). In the renal tissues, the CD4+/CD8+ ratio had the optimal cutoff point of 0.82 with a sensitivity of 57.8% and specificity of 85%. The renal activity index was higher for the renal tissues with high CD4+/CD8+ ratios than that of tissues with low CD4+/CD8+ ratios (4.32 ± 1.55 vs. 3.37 ± 1.41, p = 0.016). Peripheral blood CD4+/CD8+ ratios of ≥0.89 or renal tissue CD4+/CD8+ ratios of < 0.82 positively correlated with poor renal prognosis in patients with anti-GBM nephritis. Conclusions The CD4+/CD8+ ratio was associated with renal activity index both in peripheral blood and renal tissue and predicts the renal prognosis of patients with anti-GBM nephritis.

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