Structures of benzodiazepine recognition site ligands

2020 ◽  
pp. 85-98
Author(s):  
Adam Doble ◽  
Ian L Martin ◽  
David Nutt
Keyword(s):  
Recognition Site

Autoantibody Selectively Inhibits Binding of von Willebrand Factor to Glycoprotein Ib. Recognition Site Is Located in the A1 Loop of von Willebrand Factor

1997 ◽  
Vol 77 (04) ◽  
pp. 760-766 ◽  
Author(s):  
Hiroshi Mohri ◽  
Etsuko Yamazaki ◽  
Zekou Suzuki ◽  
Toshikuni Takano ◽  
Shumpei Yokota ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Significant Inhibition ◽  
Von Willebrand Disease ◽  
Recognition Site ◽  
Severe Bleeding ◽  
Bleeding Tendency ◽  
Virtual Absence ◽  
Heavy Chains ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryA 20-year-old man with severe von Willebrand disease recently presented a progressive bleeding tendency, characterized recurrent subcutaneous hemorrhages and cerebral hemorrhage. Mixing and infusion studies suggested the presence of an inhibitor directed against vWF:RCo activity of von Willebrand factor (vWF) without significant inhibition of the FVIII:C. The inhibitor was identified as an antibody of IgG class. The inhibitor inhibited the interaction of vWF in the presence of ristocetin and that of asialo-vWF with GPIb while it partially blocked botrocetin-mediated interaction of vWF to GPIb. The inhibitor reacted with native vWF, the 39/34kDa fragment (amino acids [aa] 480/ 481-718) and the recombinant vWF fragment (MalE-rvWF508-704), but not with Fragment III-T2 (heavy chains, aa 273-511; light chains, aa 674-728). A synthetic peptide (aa 514-542) did not inhibit vWF-inhibitor complex formation. We conclude that this is the first autoantibody of class IgG from human origin that recognizes the sequence in the A1 loop of vWF, resulting in a virtual absence of functional vWF and a concomitant severe bleeding tendency although recognition site is different from the residues 514-542 which is crucial for vWF-GPIb interaction.

scholarly journals On the Nature of the Yeast Phenylalanine Transfer Ribonucleic Acid Synthetase Recognition Site

1970 ◽  
Vol 245 (9) ◽  
pp. 2465-2468
Author(s):  
Bernard S. Dudock ◽  
Claudia DiPeri ◽  
Miriam S. Michael
Keyword(s):  
Ribonucleic Acid ◽  
Recognition Site

scholarly journals Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site

1993 ◽  
Vol 268 (20) ◽  
pp. 15118-15126 ◽  
Author(s):  
J.C. Hsieh ◽  
P.W. Jurutka ◽  
S. Nakajima ◽  
M.A. Galligan ◽  
C.A. Haussler ◽  
...  
Keyword(s):  
Vitamin D ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Vitamin D Receptor ◽  
Recognition Site ◽  
Functional Evaluation ◽  
Kinase C

scholarly journals A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18).

1990 ◽  
Vol 265 (21) ◽  
pp. 12119-12122
Author(s):  
D C Altieri ◽  
F R Agbanyo ◽  
J Plescia ◽  
M H Ginsberg ◽  
T S Edgington ◽  
...  
Keyword(s):  
Recognition Site

scholarly journals Identification of amino acids in the gamma-carboxylation recognition site on the propeptide of prothrombin.

1990 ◽  
Vol 265 (21) ◽  
pp. 12467-12473
Author(s):  
P Huber ◽  
T Schmitz ◽  
J Griffin ◽  
M Jacobs ◽  
C Walsh ◽  
...  
Keyword(s):  
Amino Acids ◽  
Recognition Site
Sign in / Sign up

Export Citation Format

Share Document