scholarly journals Three cases of pulmonary hypertension crisis following radical operation for congenital heart diseases. Including a case for which continuous recording of systemic blood pressure, pulmonary blood pressure, and left atrial pressure was obtained and whose life was saved with PGE1.

1989 ◽  
Vol 18 (4) ◽  
pp. 610-612
Author(s):  
K. Sakamoto
Keyword(s):  
Blood Pressure ◽  
Pulmonary Hypertension ◽  
Left Atrial ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Systemic Blood Pressure ◽  
Left Atrial Pressure ◽  
Congenital Heart Diseases ◽  
Radical Operation ◽  
Systemic Blood

scholarly journals Vasoactive mediators in congenital heart diseases with shunt lesions and pulmonary hypertension

2013 ◽  
Vol 43 ◽  
pp. 976-985
Author(s):  
Fatma Sedef TUNAOĞLU ◽  
Ayşe ZENGİN TURAN ◽  
Fatma Rana OLGUNTÜRK ◽  
Serdar KULA ◽  
Ayşe Deniz OĞUZ
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Vasoactive Mediators

Prevalence of Pulmonary Hypertension and Renal Dysfunction by Systemic Blood Pressure Categories in Sickle Cell Disease.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3169-3169 ◽  
Author(s):  
Victor R. Gordeuk ◽  
Mark T. Gladwin ◽  
Gregory Kato ◽  
Oswaldo Castro
Keyword(s):  
Blood Pressure ◽  
Pulmonary Hypertension ◽  
Renal Dysfunction ◽  
Sickle Cell ◽  
Systemic Blood Pressure ◽  
Systemic Hypertension ◽  
Cell Disease ◽  
Systemic Blood ◽  
Creatinine Concentration ◽  
Increased Risk

Abstract In an emerging paradigm of sickle cell disease (SCD) vasculopathy, the risk for pulmonary and systemic hypertension, renal dysfunction, proteinuria, stroke and early death may be related to the degree of hemolysis, nitric oxide scavenging and resultant damage to the vasculature (JAMA2005;293:1653). The systemic blood pressure (BP) in sickle cell anemia (SS) is lower than in normal subjects. Yet, the concept of relative systemic hypertension has been proposed because SS pts. Have higher BP than subjects with other forms of congenital anemias (Am J Med Sci 1993). Furthermore, apparently minor BP increases in SS are associated with stroke risk (Am J Med Sci1993;305:150, Am J Med1997;102:171). We hypothesized that in contrast to otherwise healthy individuals without SCD, systolic blood pressures (sBP) of 120 to 139 mm Hg define relative hypertension in SCD and identify patients at increased risk for vasculopathy and its complications. We analyzed entry data from 195 adult patients enrolled in the prospective Sickle Cell Pulmonary Hypertension Screening Study (NEJM2004;350:886), and stratified their ECHO-determined tricuspid regurgitant jet velocity (TRV) and serum creatinine concentration according to sBP categories. As shown in Figure 1, among Hb SS and S beta thal patients, the prevalence of pulmonary hypertension (PHTN, TRV 2.5 m/sec or greater) was 26% with sBP <120 mm Hg, 36% with sBP 120–139 mm Hg and 89% with sBP 140 mm Hg or higher (P <0.0005 for trend). Similarly, the prevalence of a serum creatinine concentration of 1.0 mg/dL or higher was 7% with sBP <120 mm Hg, 13% with sBP 120–139 mm Hg and 30% with sBP 140 mm Hg or higher (P = 0.002 for trend, Figure 2). The increasing prevalences of PHTN and renal dysfunction with the three progressively higher sBP categories are consistent with our hypothesis that sBP 120–139 represents relative hypertension and increased risk for vascular complications in patients with SCD. Whether treatment of relative hypertension in sickle patients would improve vasculopathy and lower their risk for PHTN, renal impairment or other complications such as stroke, is unknown. Consideration should be given to clinical trials to answer this important question. Figure Figure Figure Figure

Surgical Treatment of Congenital Heart Diseases in Adults

2001 ◽  
Vol 82 (3) ◽  
pp. 161-164
Author(s):  
V. N. Medvedev ◽  
Sh. M. Kurmaev ◽  
G. I. Kharitonov ◽  
R. F. Sadekov ◽  
I. I. Vagizov
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Interatrial Septum ◽  
High Rate ◽  
Congenital Heart Diseases ◽  
Rural Regions ◽  
Results Of Treatment ◽  
Secondary Defect ◽  
The Right

The results of treatment of 701 adult patients with congenital heart diseases from 1987 to 1997 are analyzed. As many as 248 operations with general postoperative lethality 3,2% are made. It is concluded on the necessity of improving the diagnosis of congenital heart diseases in children, especially in rural regions in relation to the high rate of inopportune revealing heart diseases resulting in the increase of the number of inoperable patients with pronounced pulmonary hypertension. The presence of symptoms or pronounced blood escape out of the left article into the right one in the absence of pulmonary hypertension is considered the indication to the radical correction of secondary defect of interatrial septum in adults. The radical heart disease correction in conditions of moderate hypotermy without artificial blood circulation is recommended in small secondary defect of interatrial septum

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