Human pandemic influenza virus

2013 ◽  
pp. 218-239
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza

scholarly journals Lack of evidence for pre-symptomatic transmission of pandemic influenza virus A(H1N1) 2009 in an outbreak among teenagers; Germany, 2009

2011 ◽  
Vol 5 (6) ◽  
pp. e499-e503 ◽  
Author(s):  
Julia Hermes ◽  
Helen Bernard ◽  
Udo Buchholz ◽  
Michaela Spackova ◽  
Johann Löw ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Influenza Virus A

scholarly journals Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets

2010 ◽  
Vol 84 (15) ◽  
pp. 7695-7702 ◽  
Author(s):  
Grace L. Chen ◽  
Elaine W. Lamirande ◽  
Chin-Fen Yang ◽  
Hong Jin ◽  
George Kemble ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Vaccine Candidate ◽  
Influenza Virus Vaccine ◽  
Influenza Viruses ◽  
Antibody Responses ◽  
Wild Type ◽  
Preparedness Planning ◽  
Kinetics Of ◽  
Reactive Antibody

ABSTRACT H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.

Seeking a Pale Horse: The 1918 Pandemic Influenza Virus

2002 ◽  
pp. 217-235
Author(s):  
Thomas G. Fanning ◽  
Ann H. Reid ◽  
Thomas A. Janczewski ◽  
Jeffery K. Taubenberger
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza

scholarly journals Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3915 ◽  
Author(s):  
Raquel Almansa ◽  
Pamela Martínez-Orellana ◽  
Lucía Rico ◽  
Verónica Iglesias ◽  
Alicia Ortega ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza Virus ◽  
Pandemic Influenza ◽  
Dual Role ◽  
Viral Clearance ◽  
Cytokine Signaling ◽  
Effective Response ◽  
Pdm09 Virus ◽  
Influenza A H1n1

Background The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed. Methods A systems biology approach was used to define gene expression profiles, histology and viral dynamics in the lungs of healthy immune-competent mice with pneumonia caused by a human influenza A (H1N1) pdm09 virus, which successfully resolved the infection. Results Viral infection activated a marked pro-inflammatory response at the lung level paralleling the emergence of histological changes. Cellular immune response and cytokine signaling were the two signaling pathway categories more representative of our analysis. This transcriptome response was associated to viral clearance, and its resolution was accompanied by resolution of histopathology. Discussion These findings suggest a dual role of pulmonary inflammation in viral clearance and development of pneumonia during non-fatal infection caused by the 2009 pandemic influenza virus. Understanding the dynamics of the host’s transcriptomic and virological changes over the course of the infection caused by A (H1N1) pdm09 virus may help identifying the immune response profiles associated with an effective response against influenza virus.

scholarly journals Rapidly progressing A/H1N1 (09) pandemic influenza virus infection in pregnancy

2012 ◽  
Vol 113 (06) ◽  
pp. 379-381
Author(s):  
S. Celen ◽  
S. Ozyer ◽  
S. Unlu ◽  
S. Saygan ◽  
O. Uzunlar ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Pandemic Influenza ◽  
Influenza Virus Infection ◽  
In Pregnancy

scholarly journals H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

2008 ◽  
Vol 4 (8) ◽  
pp. e1000115 ◽  
Author(s):  
Lucy A. Perrone ◽  
Julie K. Plowden ◽  
Adolfo García-Sastre ◽  
Jacqueline M. Katz ◽  
Terrence M. Tumpey
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Pandemic Influenza ◽  
Influenza Virus Infection

scholarly journals Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus

2004 ◽  
Vol 2 (11) ◽  
pp. 909-914 ◽  
Author(s):  
Ann H. Reid ◽  
Jeffery K. Taubenberger ◽  
Thomas G. Fanning
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Genetic Origins

scholarly journals Contemporary Seasonal Influenza A (H1N1) Virus Infection Primes for a More Robust Response To Split Inactivated Pandemic Influenza A (H1N1) Virus Vaccination in Ferrets

2010 ◽  
Vol 17 (12) ◽  
pp. 1998-2006 ◽  
Author(s):  
Ali H. Ellebedy ◽  
Thomas P. Fabrizio ◽  
Ghazi Kayali ◽  
Thomas H. Oguin ◽  
Scott A. Brown ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Influenza Viruses ◽  
Inactivated Vaccine ◽  
H1n1 Influenza Virus ◽  
Influenza A H1n1

ABSTRACT Human influenza pandemics occur when influenza viruses to which the population has little or no immunity emerge and acquire the ability to achieve human-to-human transmission. In April 2009, cases of a novel H1N1 influenza virus in children in the southwestern United States were reported. It was retrospectively shown that these cases represented the spread of this virus from an ongoing outbreak in Mexico. The emergence of the pandemic led to a number of national vaccination programs. Surprisingly, early human clinical trial data have shown that a single dose of nonadjuvanted pandemic influenza A (H1N1) 2009 monovalent inactivated vaccine (pMIV) has led to a seroprotective response in a majority of individuals, despite earlier studies showing a lack of cross-reactivity between seasonal and pandemic H1N1 viruses. Here we show that previous exposure to a contemporary seasonal H1N1 influenza virus and to a lesser degree a seasonal influenza virus trivalent inactivated vaccine is able to prime for a higher antibody response after a subsequent dose of pMIV in ferrets. The more protective response was partially dependent on the presence of CD8+ cells. Two doses of pMIV were also able to induce a detectable antibody response that provided protection from subsequent challenge. These data show that previous infection with seasonal H1N1 influenza viruses likely explains the requirement for only a single dose of pMIV in adults and that vaccination campaigns with the current pandemic influenza vaccines should reduce viral burden and disease severity in humans.

scholarly journals Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain

2013 ◽  
Vol 10 (1) ◽  
pp. 47 ◽  
Author(s):  
Masatoshi Okamatsu ◽  
Yoshihiro Sakoda ◽  
Takahiro Hiono ◽  
Naoki Yamamoto ◽  
Hiroshi Kida
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Influenza Virus Strain ◽  
2009 H1n1
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