The risk factors and progression of retinopathy of prematurity in extremely low birth weight infants

The number of premature babies, including those with extremely low birth weight (ELBW), is steadily growing every year. In surviving ELBW infants, retinopathy of prematurity (ROP) more often develops, which has a more severe course, depending not only on the degree of immaturity and somatic burden of premature babies but also on the quality of nursing. The aim of this work is to determine the risk factors for ROP progression in profoundly premature ELBW infants to optimize the tactics of their treatment. Materials and methods. We studied the case histories of 155 surviving premature ELBW infants with ROP of various stages treated in perinatal centres of the Belgorod region in 2014-2019. Results. In premature ELBW infants, ROP of varying severity was found to be diagnosed in 90% of cases. The anamnesis of the mothers of the examined patients with moderate and severe ROP was dominated by unfavorable preceding pregnancies (miscarriages, silent miscarriage and ectopic pregnancies, medical abortions).The need for preterm infants in mechanical ventilation was established to depend on the severity of ROP and the duration of mechanical ventilation (p < 0.05). Frequent, not always justified red blood transfusions leading to the replacement of fetal haemoglobin with adult haemoglobin are also essential factors in ROP progression.

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Incidence and risk factors for retinopathy of prematurity in very low and in extremely low birth weight infants in a unit-based approach in southern Brazil

Eye ◽

10.1038/sj.eye.6702924 ◽

2007 ◽

Vol 23 (1) ◽

pp. 25-30 ◽

Cited By ~ 52

Author(s):

J B Fortes Filho ◽

G U Eckert ◽

L Procianoy ◽

C K Barros ◽

R S Procianoy

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Extremely Low Birth Weight ◽

Southern Brazil ◽

Low Birth Weight Infants

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Frequency and Risk Factors for Retinopathy of Prematurity in Very Low Birth Weight Infants in NICU, BSMMU

TAJ Journal of Teachers Association ◽

10.3329/taj.v32i1.42736 ◽

2019 ◽

Vol 32 (1) ◽

pp. 54-61

Author(s):

ANM Nurul Haque Bhuiyan ◽

MA Mannan ◽

Sanjoy Kumar Dey ◽

Nuzhat Choudhury ◽

Md Shameem ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Extremely Low Birth Weight ◽

Stepwise Logistic Regression ◽

Low Birth Weight Infants ◽

Department Of Ophthalmology ◽

Elbw Neonates

Introduction: Retinopathy of prematurity (ROP) is emerging as an important avoidable cause of childhood blindness both in developed and developing countries that primarily affects premature and very low birth weight infants. There has been paucity of studies on this topic in Bangladesh and there is no national prevalence data on ROP to understand the real burden of the disease. Hence this study has been undertaken to see its frequency and risk factors for ROP in very low weight infants admitted in NICU, BSMMU. Objectives: To find out the frequency and risk factors for ROP in very low birth weight infants admitted in NICU, BSMMU. Methodology: It was a prospective observational study and was carried out in the Department of Neonatology and Department of Ophthalmology, BSMMU from January 2014 to June 2015. Considering all inclusion and exclusion criteria total 162 very low birth weight neonates were enrolled in the study. ROP screening was performed as per unit protocol. All eye examinations were undertaken by experienced ophthalmologist who was especially trained in ROP. Result: Out of 162 study population, one hundred forty fore (88.9%) were very low birth weight, 18(11.1%) were extremely low birth weight and mean birth weight was 1294.35 (SD: 180.96) g. Frequency of ROP was 38(23.5%), where 30(20.83%) among very low birth weight (VLBW) and 8(44.44%) were among ELBW neonates. Out of 38 ROP cases, 5(13%) had stage 1 retinopathy, 3(8%) had stage 2 retinopathy, 16(42.1%) had stage 3 and remaining 14(36.8%) neonates had APROP. On univariate analysis seventeen factors were found to be significant but on stepwise logistic regression analysis only lower gestational age [OR=5.014; CI(95%),2.160-11.640, P=.001] and use of mechanical ventilator [OR=1.925; CI(95%),1.133-3.269, P=.015] was found to be the most significant for causation of ROP. Conclusion: The overall frequency of ROP was 38(23.5%), where as 30(20.83%) were among VLBW and 8(44.44%) were among ELBW neonates. Prevention of prematurity and judicious use of ventilator may reduce the incidence and severity of ROP TAJ 2019; 32(1): 54-61

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The Incidence and Risk Factors of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants in Turkey

Medical Science Monitor ◽

10.12659/msm.892262 ◽

2014 ◽

Vol 20 ◽

pp. 1647-1653 ◽

Cited By ~ 17

Author(s):

Ahmet Yagmur Bas

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants

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Faculty Opinions recommendation of Effects of Multiple Ventilation Courses and Duration of Mechanical Ventilation on Respiratory Outcomes in Extremely Low-Birth-Weight Infants.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725821841.793530824 ◽

2017 ◽

Author(s):

Vineet Bhandari

Keyword(s):

Mechanical Ventilation ◽

Birth Weight ◽

Low Birth Weight ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants ◽

Respiratory Outcomes

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A Prospective Study on Retinopathy of Prematurity in a Teritiary Care Center

Asian Journal of Clinical Pediatrics and Neonatology ◽

10.47009/ajcpn.2020.8.1.14 ◽

2020 ◽

Vol 8 (1) ◽

pp. 58-60

Author(s):

Mahaboob Basha Kallur ◽

K. Muralidhar

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Neonatal Intensive Care ◽

Care Center ◽

Low Birth Weight Infants ◽

Cross Sectional ◽

Retinal Neovascularisation ◽

Premature Babies ◽

Low Birth Weight Babies

Background: Retinopathy of prematurity (ROP) is a vaso-proliferative retinopathy which occurs mostly in premature babies. The pathological change in ROP is peripheral retinal neovascularisation which may regress completely or leave sequelae from mild myopia to bilateral total blindness. International classification of ROP helped in uniform documentation and staging of ROP. In India, the incidence of ROP is between 38 and 51.9 p.c among low-birth-weight infants. Aim & Objectives: To estimate the incidence of ROP among premature and / or low birth weight babies who were born and admitted to neonatal intensive care unit and attending neonatal follow-up clinic.Subjects and Methods:A hospital based, prospective analytical cross-sectional study was conducted in Department of Pediatrics at Shadan Institute of Medical Sciences, Teaching hospital and research center, Hyderabad, Telangana for a period of 6 months from 1st October 2018 to 31st March 2019. Prior to the study initiation, ethical clearance was obtained and written consent was taken from the parents of the respective babies. The study subjects included premature babies (less than or equal to 35 weeks of gestation) or low birth weight babies (less than or equal to 1500 grams). A predesigned, pre-tested, semi-structured proforma was used to collected the data. The data was collected, entered in Microsoft excel-2013 and analyzed using SPSS version-22 (trial). Data was presented in percentages, proportions and figures.Result:The ROP incidence in the study group was reported among 17.1 p.c of the study subjects.Conclusion:Low birth weight and prematurity are important risk factors for ROP.

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