scholarly journals EVALUATION OF ANTI-HISTAMINIC ACTIVITY OF KASANKUSHA RASA IN GUINEA PIGS

2021 ◽  
Vol 9 (9) ◽  
pp. 2037-2043
Author(s):  
Divya Shekar.B ◽  
Surekha S Medikeri
Keyword(s):  
Shelf Life ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Herbal Preparations

Many formulations in Rasashastra textbooks are indicated for allergic conditions like Bronchial Asthma. Ra- saushadhis are more effective than herbal preparations owing to their infinite shelf life, lower dose, faster action and palatability1. Kasankusha rasa is a Kharaliya preparation indicated in various conditions of Shwasa and Kasa as per the reference of Rasa Yoga Sagara2 which is composed of Hingula, Maricha, Mustha, Vatsanabha and Tankana. It is chosen for the present study, focusing on its Anti-Histaminic effect. Instead of using Kajjali which is a tedious procedure to prepare as in other formulations, this yoga contains ShuddhaHingula thus easing the pro- cedure. Hence, an attempt is made to validate the classical indications of the formulation to the current bio- medicine scenario. Keywords: Kasankusha rasa, Rasashastra, Shwasa ,Kasa, Anti-Histaminic activity

scholarly journals ENDOGENOUS NITRIC OXIDE INDUCES AIRFLOW LIMITATION IN BRONCHIAL ASTHMA OF GUINEA PIGS

1997 ◽  
Vol 75 ◽  
pp. 77
Author(s):  
H. IIJIMA ◽  
Y. UCHIDA ◽  
T. ENDO ◽  
A. NOMURA ◽  
M. SHIRATO ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Airflow Limitation ◽  
Endogenous Nitric Oxide

scholarly journals CHARACTERISTIC OF INDIVIDUAL INDICATORS OF ENDOGENOUS INTOXICATION IN THE EXPERIMENTAL ASTHMA DYNAMICS AND THEIR CORRECTION BY THIOTRIASOLIN

2016 ◽  
Vol 6 ◽  
pp. 52-56
Author(s):  
Marta Kolishetska
Keyword(s):  
Experimental Model ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Gradual Increase ◽  
Numerical Results ◽  
Static Method ◽  
Endogenous Intoxication ◽  
Direct Dependence ◽  
Positive Effect ◽  
Methods Numerical

The aim of this work was to find out the specifics of changes in endogenous intoxication, middle mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of animals for experimental asthma in different periods of its development and to correct them by thiotriazolin. Material and methods. Researches were carried out on 72 guinea-pigs (males), which were divided into 6 groups for 12 animals in each of them. The last sixth group included animals that were treated by thiotriazolin. The drug thiotriazolin rate of 100 mg / kg intramuscularly since 23rd day of the experiment for 10 days was administered in the animals of sixth group. Experimental model of bronchial asthma was restored on guinea-pigs by the V.I. Babych method (1979). In all groups of animals there were determined the middle mass molecules concentration in blood in the wave of 254 nm by I.A.Volchehorskiy, D.A.Dyatlova, E.I. Lvovska and others methods and EII by V.K. Kazymyrko V.I. Maltsev methods. Numerical results were adapted with static method using Student’s criteria. Results of the research. The highest level of endogenous intoxication in the blood was in the fifth group of guinea pigs with asthma (33rd day), indicating the direct dependence of the antigenic effect on their severity. Using of the thiotriazolin within 10 days (from 23rd to 33rd day) caused the decrease of the MMM254 concentration and EII in serum compared with a group of guinea pigs, that were not entered the medicine. It approved its treating effect. Conclusions. So, the research of middle mass molecules and erythrocyte intoxication index indicators in different periods of experimental asthma showed their gradual increase in serum of guinea pigs with the greatest severity in 33rd day of the experiment. It might indicate the development of endogenous intoxication animals. But the using of thiotriazolin caused the decreasing of these indicators. That gives a reason to state its positive effect on some markers of endogenous intoxication and feasibility of further researches.

scholarly journals The influence of thiotriazoline on the change of immune system in the blood of guinea-pigs under the conditions of development of experimental bronchial asthma

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
M. S. Reheda ◽  
М. А. Kolishetska ◽  
V. R. Yurevych
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Blood Plasma ◽  
B Lymphocytes ◽  
Bronchial Asthma ◽  
Functional State ◽  
Immune Complexes ◽  
Guinea Pigs ◽  
Stimulation Of ◽  
Plasma Activity

<p>The aim of our research was to determine the character of the role and functional state of separate indexes<br />of the immune system in blood of guinea-pigs under the conditions of the development of experimental bronchial<br />asthma (BA ) and estimation of thiotriazoline influence on them. Decreasing of T-lymphocytes, stimulation of humoral<br />link of immunity, namely increasing of B-lymphocytes and immunoglobulins of A, M and G, elevation of circulatory<br />immune complexes and slump of complement blood plasma activity had been determined in this research. Immune<br />correcting action of thiotriazoline upon the pointed out indices in case of BA is revealed.</p>

scholarly journals A new bronchial asthma model using calcium ionophore A23187 in guinea pigs.

1989 ◽  
Vol 51 (3) ◽  
pp. 446-449 ◽  
Author(s):  
Miwa MISAWA ◽  
Toshihiko KAWAMURA ◽  
Kiyoteru TAKENOUCHI
Keyword(s):  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Ionophore A23187 ◽  
Asthma Model
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