scholarly journals The Role of Oral Cyclosporine in the Management of Steven Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Multicentric Observational Study

2021 ◽  
Vol 02 (03) ◽  
Author(s):  
Rajnish Kumar ◽  
Rashmi Singh ◽  
Uday Kumar Udayan
Keyword(s):  
Observational Study ◽  
Toxic Epidermal Necrolysis ◽  
Johnson Syndrome ◽  
Steven Johnson Syndrome

scholarly journals Toxic Epidermal Necrolysis and Steven–Johnson Syndrome: A Comprehensive Review

2020 ◽  
Vol 9 (7) ◽  
pp. 426-439 ◽  
Author(s):  
Olivia A. Charlton ◽  
Victoria Harris ◽  
Kevin Phan ◽  
Erin Mewton ◽  
Chris Jackson ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Comprehensive Review ◽  
Johnson Syndrome ◽  
Steven Johnson Syndrome

scholarly journals DRUG-INDUCED STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS

2016 ◽  
Vol 65 (4) ◽  
pp. 377-381
Author(s):  
Dalia Dop ◽  
◽  
Desdemona Stepan ◽  
Cristian Gheonea ◽  
Elena Carmen Niculescu ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Rare Diseases ◽  
Intravenous Immunoglobulins ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Johnson Syndrome ◽  
Medical Emergencies ◽  
Steven Johnson Syndrome ◽  
Restitutio Ad Integrum

Steven-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare diseases that appear following the administration of risk drugs. Both are severity grades of the same condition and are considered medical emergencies, because they are potentially lethal. They are characterized by mucocutaneous tenderness, erythema, necrosis and bullous detachment similar to extended burns. We report 3 cases of SJS/TEN in which the etiology was probably drug-related (Paracetamol, Atomoxetinum, Sulfamethoxazolum + trimethoprinum), with restitutio ad integrum following the administration of intravenous immunoglobulins.

scholarly journals Steven-Johnson Syndrome in Child

2019 ◽  
Vol 70 (9) ◽  
pp. 3213-3215
Author(s):  
Ramona Mihaela Nedelcuta ◽  
Vlad Dumitru Baleanu ◽  
Dragos Virgil Davitoiu ◽  
Tiberiu Stefanita Tenea Cojan ◽  
Cosmin Alexandru Ciora ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Toxic Epidermal Necrolysis ◽  
Rare Diseases ◽  
Early Investigation ◽  
Direct Relation ◽  
Skin Damage ◽  
Effective Prevention ◽  
Johnson Syndrome ◽  
Skin Integrity ◽  
Steven Johnson Syndrome

Steven-Johnson Syndrome and NET (toxic epidermal necrolysis), different expressions of the same condition were named according to the percentage of affected skin: [10% in Steven-Johnson Syndrome and]30% in NET. Small ages may be a target for these rare diseases, in direct relation to drug abuse (antibiotics, NSAIDs, antiepileptics, etc.). Survival depends on the rapid response of the causative agent, the early investigation of the therapy to block Fas-FasL interaction and to reestablish skin integrity (Fas-receptor on the surface of cells involved in apoptosis). Massive skin damage is associated with a severe prognosis, as is the age of the baby.It is necessary to use wise the medication or automedication for a complete and effective prevention of Steven-Johnson Syndrome.

scholarly journals Association of the HLA-B alleles with carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype

2017 ◽  
Vol 18 (18) ◽  
pp. 1643-1648 ◽  
Author(s):  
Rika Yuliwulandari ◽  
Erna Kristin ◽  
Kinasih Prayuni ◽  
Qomariyah Sachrowardi ◽  
Franciscus D Suyatna ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

scholarly journals The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

2021 ◽  
Vol 27 ◽  
pp. 107602962095083
Author(s):  
Michael Sadek ◽  
Omer Iqbal ◽  
Fakiha Siddiqui ◽  
Sean Till ◽  
Melissa Mazariegos ◽  
...  
Keyword(s):  
Skin Biopsy ◽  
Toxic Epidermal Necrolysis ◽  
Lichen Planus ◽  
Stevens Johnson Syndrome ◽  
Corneal Epithelial ◽  
Johnson Syndrome ◽  
Tnf Α ◽  
Normal Human ◽  
Human Corneal Epithelial Cells

Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are Severe Cutaneous Adverse Reactions (SCARS) characterized by fever and mucocutaneous lesions leading to necrosis and sloughing of the epidermis. Conjunctival lesions are reported in 85% of patients. The pathogenesis of SJS/TEN/SCARS is not completely understood. It is hypothesized that IL-13, IL-15 and Granulysin expressed in plasma and skin may play a role. We measured the circulating levels of these cytokines in the plasma using ELISA and their expression in the skin using immunofluorescence microscopy. A total of 12 SJS/TEN skin biopsy samples (8 SJS, 2 SJS/TEN overlap and 2 TEN) were analyzed. Biopsy samples from patients with Lichen Planus (an inflammatory condition of the skin and mucous membranes) served as controls. Studies were also performed in human corneal epithelial cells where expression of these cytokines were measured following a challenge with TNF-α (0, 1, 10 and 100 ng/ml). The intensity of immunofluorescence was measured Using Imaris® software. The results showed significantly increased expression of these cytokines in the skin biopsy samples as measured by the average intensities of IL-13 (6.1 x 133.0 ± 4.231 x 10^8), and Granulysin (4.2 x 123.0 ± 4.231 x 10^8) compared to Lichen planus control (3.0 x 123.0 ±1.62 x 10^5). Increased expression of IL-13 and IL-15 were noted in cell culture studies and in the plasma samples when compared to Normal Human Plasma as controls. It is concluded that IL-13, IL-15 and Granulysin play a role in the pathogenesis of SJS/TEN.

TOXIC EPIDERMOLYSIS CAUSED BY ANTIEPILEPTIC DRUGS: CLINICAL OBSERVATIONS

2021 ◽  
Vol 100 (1) ◽  
pp. 282-287
Author(s):  
M.A. Ufimtseva ◽  
◽  
M.A. Zakharov ◽  
O.Yu. Averyanov ◽  
O.V. Kozhevnikova ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Antiepileptic Drugs ◽  
Stevens Johnson Syndrome ◽  
International Literature ◽  
Emergency Medical Care ◽  
Clinical Observations ◽  
Johnson Syndrome

Toxic epidermal necrolysis (Lyell's syndrome) and Stevens–Johnson syndrome are severe types of toxicodermia and require emergency medical care. The pathophysiology of toxicoderma is associated with an adverse drug reaction. The article provides data from Russian and international literature on the role of antiepileptic drugs in these diseases occurrence. It also presents clinical cases of toxic epidermal necrolysis in children caused by anticonvulsants intake.

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