Glucose-6- Phosphate Dehydrogenase Activity in Newborn in Jos:  A Necessary Evaluation for Icteric Neonates

Red blood cell glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme with the major role of meeting the cellular need for reductive biosynthesis and maintenance of redox status. G6PD deficiency is a common inherited enzyme defect associated with severe neonatal hyperbilirubinaemia that can result in permanent neurologic damage or death. This study was aimed at estimating the level of G6PD activity among icteric neonates to assess its usefulness in the evaluation of icteric neonates in Jos. One hundred and fifty icteric neonates (92 males and 58 females) whose parents consented were consecutively enrolled as they presented at the Special Care Baby Units (SCBU) of the Jos University Teaching Hospital (JUTH), Bingham University Teaching Hospital (BhUTH), and the Plateau State Specialist Hospital (PSSH), Jos. These subjects had their G6PD activity levels assayed using the Pointe Quantitative Diagnostic Kit (USA) while other relevant clinical information was obtained using a questionnaire. G6PD activity of the icteric neonates ranged between 0.54 and 24.18 IU/gHb with a mean of 8.02 ± 4.87 IU/gHb. Sixty-one (40.7 %), comprising 45 males and 16 female neonates were G6PD deficient with mean G6PD activity of 3.79 ± 1.37 IU/gHb while eighty-nine (59.3%) were G6PD normal with a mean G6PD activity of 10.92 ± 4.24 IU/gHb. G6PD activity in icteric neonates in Jos varies widely with a relatively high proportion of these neonates being G6PD deficient. Determination of G6PD activity in icteric neonates should therefore form an important evaluation tool for identification and intervention in those with the deficiency.

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Glucose-6- Phosphate Dehydrogenase Activity in Newborn in Jos: A Necessary Evaluation for Icteric Neonates

Journal of BioMedical Research and Clinical Practice ◽

10.46912/2i4.2019127 ◽

2019 ◽

Vol 2 (4) ◽

pp. 191-196

Author(s):

ED Jatau ◽

OB Toma ◽

OJ Egesie ◽

DO Damulak ◽

Z Ayuba ◽

...

Keyword(s):

Teaching Hospital ◽

Clinical Information ◽

Redox Status ◽

G6pd Activity ◽

University Teaching ◽

Activity Levels ◽

Evaluation Tool ◽

Plateau State ◽

Glucose 6 Phosphate Dehydrogenase

Red blood cell glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme with the major role of meeting the cellular need for reductive biosynthesis and maintenance of redox status. G6PD deficiency is a common inherited enzyme defect associated with severe neonatal hyperbilirubinaemia that can result in permanent neurologic damage or death. This study was aimed at estimating the level of G6PD activity among icteric neonates to assess its usefulness in the evaluation of icteric neonates in Jos. One hundred and fifty icteric neonates (92 males and 58 females) whose parents consented were consecutively enrolled as they presented at the Special Care Baby Units (SCBU) of the Jos University Teaching Hospital (JUTH), Bingham University Teaching Hospital (BhUTH), and the Plateau State Specialist Hospital (PSSH), Jos. These subjects had their G6PD activity levels assayed using the Pointe Quantitative Diagnostic Kit (USA) while other relevant clinical information was obtained using a questionnaire. G6PD activity of the icteric neonates ranged between 0.54 and 24.18 IU/gHb with a mean of 8.02 ± 4.87 IU/gHb. Sixty-one (40.7 %), comprising 45 males and 16 female neonates were G6PD deficient with mean G6PD activity of 3.79 ± 1.37 IU/gHb while eighty-nine (59.3%) were G6PD normal with a mean G6PD activity of 10.92 ± 4.24 IU/gHb. G6PD activity in icteric neonates in Jos varies widely with a relatively high proportion of these neonates being G6PD deficient. Determination of G6PD activity in icteric neonates should therefore form an important evaluation tool for identification and intervention in those with the deficiency.

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Glucose-6- Phosphate Dehydrogenase Activity in Newborn in Jos: A Necessary Evaluation for Icteric Neonates

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp.v2.i4.2019.127 ◽

2019 ◽

Vol 2 (4) ◽

pp. 191-196

Author(s):

ED Jatau ◽

OB Toma ◽

OJ Egesie ◽

DO Damulak ◽

Z Ayuba ◽

...

Keyword(s):

Teaching Hospital ◽

Clinical Information ◽

Redox Status ◽

G6pd Activity ◽

University Teaching ◽

Activity Levels ◽

Evaluation Tool ◽

Plateau State ◽

Glucose 6 Phosphate Dehydrogenase

Red blood cell glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme with the major role of meeting the cellular need for reductive biosynthesis and maintenance of redox status. G6PD deficiency is a common inherited enzyme defect associated with severe neonatal hyperbilirubinaemia that can result in permanent neurologic damage or death. This study was aimed at estimating the level of G6PD activity among icteric neonates to assess its usefulness in the evaluation of icteric neonates in Jos. One hundred and fifty icteric neonates (92 males and 58 females) whose parents consented were consecutively enrolled as they presented at the Special Care Baby Units (SCBU) of the Jos University Teaching Hospital (JUTH), Bingham University Teaching Hospital (BhUTH), and the Plateau State Specialist Hospital (PSSH), Jos. These subjects had their G6PD activity levels assayed using the Pointe Quantitative Diagnostic Kit (USA) while other relevant clinical information was obtained using a questionnaire. G6PD activity of the icteric neonates ranged between 0.54 and 24.18 IU/gHb with a mean of 8.02 ± 4.87 IU/gHb. Sixty-one (40.7 %), comprising 45 males and 16 female neonates were G6PD deficient with mean G6PD activity of 3.79 ± 1.37 IU/gHb while eighty-nine (59.3%) were G6PD normal with a mean G6PD activity of 10.92 ± 4.24 IU/gHb. G6PD activity in icteric neonates in Jos varies widely with a relatively high proportion of these neonates being G6PD deficient. Determination of G6PD activity in icteric neonates should therefore form an important evaluation tool for identification and intervention in those with the deficiency.

Download Full-text

Glucose-6- Phosphate Dehydrogenase Activity in Newborn in Jos: A Necessary Evaluation for Icteric Neonates

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp.v2i42019.127 ◽

2019 ◽

Vol 2 (4) ◽

pp. 191-196

Author(s):

ED Jatau ◽

OB Toma ◽

OJ Egesie ◽

DO Damulak ◽

Z Ayuba ◽

...

Keyword(s):

Teaching Hospital ◽

Clinical Information ◽

Redox Status ◽

G6pd Activity ◽

University Teaching ◽

Activity Levels ◽

Evaluation Tool ◽

Plateau State ◽

Glucose 6 Phosphate Dehydrogenase

Red blood cell glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme with the major role of meeting the cellular need for reductive biosynthesis and maintenance of redox status. G6PD deficiency is a common inherited enzyme defect associated with severe neonatal hyperbilirubinaemia that can result in permanent neurologic damage or death. This study was aimed at estimating the level of G6PD activity among icteric neonates to assess its usefulness in the evaluation of icteric neonates in Jos. One hundred and fifty icteric neonates (92 males and 58 females) whose parents consented were consecutively enrolled as they presented at the Special Care Baby Units (SCBU) of the Jos University Teaching Hospital (JUTH), Bingham University Teaching Hospital (BhUTH), and the Plateau State Specialist Hospital (PSSH), Jos. These subjects had their G6PD activity levels assayed using the Pointe Quantitative Diagnostic Kit (USA) while other relevant clinical information was obtained using a questionnaire. G6PD activity of the icteric neonates ranged between 0.54 and 24.18 IU/gHb with a mean of 8.02 ± 4.87 IU/gHb. Sixty-one (40.7 %), comprising 45 males and 16 female neonates were G6PD deficient with mean G6PD activity of 3.79 ± 1.37 IU/gHb while eighty-nine (59.3%) were G6PD normal with a mean G6PD activity of 10.92 ± 4.24 IU/gHb. G6PD activity in icteric neonates in Jos varies widely with a relatively high proportion of these neonates being G6PD deficient. Determination of G6PD activity in icteric neonates should therefore form an important evaluation tool for identification and intervention in those with the deficiency.

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Determination of some haematological parameters in malaria infected subjects in Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto, Nigeria

Bayero Journal of Pure and Applied Sciences ◽

10.4314/bajopas.v8i1.14 ◽

2015 ◽

Vol 8 (1) ◽

pp. 80 ◽

Cited By ~ 2

Author(s):

N Garba ◽

SB Danladi ◽

A Muhammad

Keyword(s):

Teaching Hospital ◽

University Teaching ◽

Haematological Parameters

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Histopathologic pattern of ovarian masses in Usmanu Danfodiyo university teaching hospital, Sokoto, Nigeria

Indian Journal of Pathology and Oncology ◽

10.18231/j.ijpo.2021.101 ◽

2021 ◽

Vol 8 (4) ◽

pp. 492-496

Author(s):

Usman Bello ◽

Umar Amina Gambo ◽

Hassan Ibrahim ◽

Aminu Abbas ◽

Muhammad S Haruna ◽

...

Keyword(s):

Ovarian Carcinoma ◽

Teaching Hospital ◽

Cystic Teratoma ◽

Clinical Information ◽

Young Female ◽

University Teaching ◽

Common Disease ◽

Malignant Tumours ◽

Fourth Decade ◽

Ovarian Masses

Diseases of the ovary are diversely arising from the different parenchymal tissue components. This span between reactive functional cysts to more debilitating ovarian carcinoma. Ovarian carcinoma is the sixth most common cancer and one of the leading cause of cancer death among female. This study aims to determine the epidemiological and histopathological patterns of ovarian masses in our setting.The study material was all the ovarian tissues biopsy specimen submitted to the Department of Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto over five years. These were fixed in 10% formal saline embedded in paraffin wax, tissue blocks formed and were sections and stained with hematoxylin and eosin on the glass slides. Request cards and case folders were used to extract clinical information. These were reviewed, analysed and presented as frequency distribution figures.There were 112 ovarian biopsies during the study period. Their ages ranged between 13 and 67 years and peaked in the fourth decade of life. Fifty per cent of all the cases were seen between the ages of 21 and 40 years. Benign neoplastic diseases formed 50% of the ovarian masses and matured cystic teratoma was the most common. Others were reactive and functional ovarian cysts (24.1%), malignant neoplastic conditions (14.3%) and inflammatory / infectious diseases (11.6%). Overall mature cystic teratoma constitutes 27% of the entire ovarian masses. Matured cystic teratoma was the most common disease of the ovary in our setting, afflicting young female, while malignant tumours dominated by serous cystadenocarcinoma affect the older age group. The fourth decade of life was the most common age of affectation. We advocate for proper histopathologic evaluation of all ovarian masses to arrive at a definitive diagnosis to offer an appropriate treatment modality.

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An Assessment of the Adequacy of Clinical Communication between Clinicians and Radiographers on the Quality of Diagnostic Ultrasound Reports: A Case of the University Teaching Hospital in Lusaka, Zambia

Edelweiss Applied Science and Technology ◽

10.33805/2576-8484.143 ◽

2018 ◽

pp. 225-231

Author(s):

Helen Nampungwe ◽

Foster Munsanje ◽

Titus Haakonde

Keyword(s):

Teaching Hospital ◽

Work Experience ◽

Social Scientist ◽

Clinical Information ◽

Diagnostic Ultrasound ◽

University Teaching ◽

Cross Sectional ◽

Clinical Communication ◽

The University

Background: Clear clinical communication between clinicians and radiographers in confirming of clinical information remains key in the provision of quality healthcare. As per procedure, clinicians make a clinical diagnosis and thereafter, request the radiographers to carry out sonographic examinations and produce Diagnostic Ultrasound Reports (DURs) based on the clinician’s request. Therefore, this study aimed at assessing the adequacy of clinical communication between clinicians and radiographers on the quality of DURs at the University Teaching Hospital (UTH) in Lusaka, Zambia. Methods: A cross-sectional descriptive study design was used. A total of 40 Clinicians were conveniently recruited into the study while 12 radiographers were purposefully sampled. Two types of special semi-structured, self-administered questionnaires were administered. Each type was to a specific professional discipline, i.e. clinicians or radiographers. Data analysis was done using Social Statistical Packages for Social Scientist Version 22. Results: The study revealed that it was a common practice for the radiographers to receive requests from the clinicians demanding for repeat of the DURs. Clinical meetings between clinicians and radiographers were irregularly held. Less than a quarter of the clinicians lacked specialized training in Diagnostic Ultrasound. The study further revealed that practitioners’ gender had no effect on the adequacy of communication between clinicians and radiographers while qualifications and work experience had effect. Conclusion: The study showed that communication between clinicians and radiographers at the UTH was inadequate. The major causes to this inadequacy included the use of unstandardized radiological request forms and lack of regular clinical meetings.

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