Serious Antimalaria Resistance, Genetic Markers of Kelch 13, Plasmepsine 2 Cnv Associated with Dihydroartemisinine - Piperaquine Resistance in Plasmodium Falciparum Population in Malaria Endemic Zone Of Dak Lak Province, 2019-2020

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Huynh Hong Quang
Keyword(s):  
Plasmodium Falciparum ◽  
Genetic Markers ◽  
Falciparum Population ◽  
Kelch 13

Detection of Genetic markers associated with Plasmodium falciparum drug resistance among malaria patients in Kaduna State, Nigeria

2021 ◽  
Vol 42 (2) ◽  
pp. 206-213
Author(s):  
G.Y. Benjamin ◽  
H.I. Inabo ◽  
M.H.I. Doko ◽  
B.O. Olayinka
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Phylogenetic Tree ◽  
Genetic Markers ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Health Concern ◽  
Cross Sectional ◽  
Blood Samples ◽  
Test Kit

Malaria is a disease of public health concern in Nigeria and sub-Saharan Africa. It is caused by intracellular parasites of the genus Plasmodium. The aim of this study was to detect genetic markers associated with Plasmodium falciparum drug resistance among malaria patients in Kaduna State, Nigeria. The study was a cross-sectional study that lasted from May 2018 to October 2018. Three hundred blood samples were collected from consenting individuals attending selected hospitals, in the three senatorial districts of Kaduna State, Nigeria. Structured questionnaire were used to obtain relevant data from study participants. The blood samples were screened for malaria parasites using microscopy and rapid diagnostic test kit. Polymerase Chain Reaction was used for detection of the drug resistance genes. Pfcrt, pfmdr1, pfdhfr, pfdhps and pfatpase6 genes were detected at expected amplicon sizes from the malaria positive samples. The pfatpase6 PCR amplicons were sequenced and a phylogenetic tree was created to determine their relatedness. Result showed that Pfcrt (80%) had the highest prevalence, followed by pfdhfr (60%), pfmdr1 (36%) and pfdhps (8%). Pfatpase6 was also detected in 73.3% of the samples, and a phylogenetic tree showed relatedness between the pfatpase6  sequences in this study and those deposited in the GenBank. In conclusion, the study detected that Plasmodium falciparum genes were associated with drug resistance to commonly used antimalarials.

The question of Plasmodium falciparum population structure

2001 ◽  
Vol 17 (8) ◽  
pp. 351-353 ◽  
Author(s):  
Philip Awadalla ◽  
David Walliker ◽  
Hamza Babiker ◽  
Margaret Mackinnon
Keyword(s):  
Plasmodium Falciparum ◽  
Population Structure ◽  
Falciparum Population

scholarly journals Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

2021 ◽  
Vol 27 (1) ◽  
pp. 294-296
Author(s):  
Clara Bergmann ◽  
Welmoed van Loon ◽  
Felix Habarugira ◽  
Costanza Tacoli ◽  
Julia C. Jäger ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Kelch 13

scholarly journals Plasmodium falciparum Kelch 13 mutations and treatment response in patients in Hpa-Pun District, Northern Kayin State, Myanmar

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Craig A. Bonnington ◽  
Aung Pyae Phyo ◽  
Elizabeth A. Ashley ◽  
Mallika Imwong ◽  
Kanlaya Sriprawat ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Treatment Response ◽  
Kelch 13

scholarly journals Differential genetic hitchhiking around mutant pfcrt alleles in the Indian Plasmodium falciparum population

2011 ◽  
Vol 67 (3) ◽  
pp. 600-608 ◽  
Author(s):  
Vanshika Lumb ◽  
Rahul Madan ◽  
Manoj K. Das ◽  
Vipin Rawat ◽  
Vas Dev ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Genetic Hitchhiking ◽  
Falciparum Population

scholarly journals Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0157949 ◽  
Author(s):  
Praveen Kumar Bharti ◽  
Himanshu Singh Chandel ◽  
Amreen Ahmad ◽  
Sri Krishna ◽  
Venkatachalam Udhayakumar ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Deletion ◽  
Falciparum Population

scholarly journals A clonal Plasmodium falciparum population in an isolated outbreak of malaria in the Republic of Cabo Verde

Parasitology ◽  
1999 ◽  
Vol 118 (4) ◽  
pp. 347-355 ◽  
Author(s):  
A. P. AREZ ◽  
G. SNOUNOU ◽  
J. PINTO ◽  
C. A. SOUSA ◽  
D. MODIANO ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Genetic Analysis ◽  
Epidemiological Data ◽  
Parasite Line ◽  
Cross Sectional ◽  
Blood Samples ◽  
Cabo Verde ◽  
The Republic ◽  
Santiago Island ◽  
Falciparum Population

We present the first parasitological, molecular and longitudinal analysis of an isolated outbreak of malaria. This outbreak occurred on Santiago Island (Republic of Cabo Verde), a region where malaria is hypoendemic and controlled, and thus the population is considered non-immune. Blood samples were collected from the inhabitants over 1 month and during cross-sectional surveys in the following year. The presence and nature of the parasites was determined by PCR. Plasmodium falciparum was the only species detected. Genetic analysis revealed that the circulating parasites were genetically homogeneous, and probably clonal. Gametocytes were found throughout this period. Our data suggest that this represented a focal outbreak, resulting in the infection of at least 40% of the villagers with a clonal parasite line. Thus, P. falciparum infections can persist for at least 1 year in a substantial proportion (10%) of the hosts. Implications for malaria control and the interpretation of epidemiological data are discussed.

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