scholarly journals To Compare Neutrophil Lymphocyte Ratio with Other Parameters in Acute Exacerbation of COPD and Stable COPD: A Hospital Based Study

2020 ◽  
Vol 9 (1) ◽  
pp. PM20-PM23
Author(s):  
Kailash Sharma ◽  
Gajendra Singh ◽  
Ummed Singh
Keyword(s):  
Acute Exacerbation ◽  
Complete Blood Count ◽  
Cost Effective ◽  
Mean Value ◽  
Normal Range ◽  
Acute Exacerbation Of Copd ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Wbc Count ◽  
Exacerbation Of Copd

Background: White blood cell (WBC) count and its subtypes are also well known systemic inflammatory markers. The ratio of neutrophils to lymphocytes (NLR), which is calculated from complete blood count with differential, is an inexpensive widely available marker of inflammation. The aim of this study to compared the neutrophil lymphocyte ratio with other parameters in acute exacerbation of COPD and stable COPD.Subjects and Methods:A Hospital based comparative study done on 50 Patients with COPD (stable/ exacerbation) attending at Government Medical College, Bharatpur, Rajasthan. While the upper limit of neutrophils count for normal range was set at 8x109/l, the lower limit of lymphocyte count for the normal range was set at 0.9x109/l. NLR was calculated as the ratio of neutrophils to lymphocytes, both of which were obtained from the same automated blood samples for the study.Results:Our study showed that the comparison of mean value of age, BMI & pack years was statistically significant (P=0.0112, P<0.0001 & P=0.0141 respectively) in between groups. The comparison of mean value of NLR was statistical significant (P=0.0009) in between groups. NLR measurement demonstrated a sensitivity and specificity of 40%and 77.14%. PPV and NPV for NLR were 63.64%and 56.25%, and OR and RR were 2.250 and 1.455. A positive correlation was determined between NLR and CRP (r=0.482; p<0.05).Conclusion: NLR, like CRP, both readily available and simple parameters, could also be used as a cost-effective marker of inflammation in AECOPD.

scholarly journals Mean Platelet Volume and Neutrophil/Lymphocyte Ratio among Patients with Ulcerative Colitis as an Indicator of Activation

2021 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Kadir Serkan Yalcin
Keyword(s):  
Ulcerative Colitis ◽  
Platelet Count ◽  
Mean Platelet Volume ◽  
Complete Blood Count ◽  
Activity Index ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Wbc Count ◽  
Two Parameters

Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in activation period among patients with ulcerative colitis (UC). Methods: Overall, 83 patients (49 female and 34 male) diagnosed with UC were retrospectively screened and includ- ed in this study. The complete blood count results, including hemoglobin, white blood cell (WBC) count, NLR, platelet count, and MPV, of all patients were recorded in both activation and remission periods. The serum C-reactive protein (CRP) and sedimentation levels of all patients were also recorded. Endoscopic disease activities (endoscopic activity index (EAI)) were also noted. Results: Compared with the remission periods, MPV values were statistically significantly lower (p=0.023) and NLR values were statistically significantly higher (p=0.011) in activation periods. In the correlation analysis, MPV levels were correlated with disease age (p=0.019), hemoglobin (p=0.012), WBC count (p=0.009), platelet count (p=0.001), sedimentation rate (p=0.001), CRP levels (p=0.009), and EAI (p=0.008) during activation periods. Conversely, the NLR did not correlate with MPV, hemoglobin, WBC, platelet count, or sedimentation and CRP levels; however, the NLR was also correlated with EAI (p=0.036). Discussion and Conclusion: We have studied two inexpensive, easily applicable, and noninvasive serum biomarkers, MPV and NLR, to determine UC activation and found that these two parameters are well correlated with other inflam- matory markers and EAI.

scholarly journals Pattern of Serum Electrolytes Imbalance among Patients with Acute Exacerbation of COPD Admitted in a Tertiary Level Hospital

2020 ◽  
Vol 15 (1) ◽  
pp. 24-27
Author(s):  
Suranjit Kumar Saha ◽  
Md Yusuf Ali ◽  
MM Shahin Ul Islm ◽  
Khan Mohammad Arif ◽  
Mohammad Anisur Rahman Hawlader ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Chronic Obstructive ◽  
Normal Range ◽  
Serum Electrolytes ◽  
College Hospital ◽  
Cross Sectional ◽  
Metabolic Derangement ◽  
Acute Exacerbation Of Copd ◽  
The Mean ◽  
Exacerbation Of Copd

Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease and there is not yet a cure. Not only in Bangladesh but also worldwide the incidence of COPD is increasing. The disease is associated with some metabolic derangement such as electrolytes imbalance. Those factors further worsen the disease course. As a result COPD related morbidity, mortality and cost to health systems are also increasing. This cross-sectional observational study was conducted in Faridpur Medical College Hospital (FMCH) over 6 months among 100 patients who were admitted with acute exacerbation of COPD. The mean age was (58.13 ± 9.96) years. In this study serum electrolytes were found below the normal range in 68 (68%) cases and within normal range in 32(32%) cases. Isolated hyponatremia was observed in 36(53%) and 15(22%) had isolated hypokalaemia. Both hyponatremia and hypokalaemia was found in 17(25%) cases. The mean serum sodium level was (133.82±2.52) mmol/l. Among patients with isolated hyponatremia, 24(67%) had mild hyponatremia and 12(33%) got moderate hyponatremia. Again the mean serum potassium was (3.45±0.23) mmol/l. Among patients with isolated hypokalaemia, 10(67%) had mild hypokalaemia and 5(33%) had moderate hypokalaemia. Both hyponatremia and hypokalaemia was observed in one fourth of total electrolytes depleted cases and all were within the mild range. No patient had severe hyponatremia or hypokalaemia. Faridpur Med. Coll. J. Jan 2020;15(1): 24-27

Study of serum magnesium levels in acute exacerbation of COPD

2016 ◽  
Vol 3 (1) ◽  
pp. 56-64
Author(s):  
M.G.Krishna Murthy ◽  
◽  
Tarigopula Pramod Kumar ◽  
M. Kiran kumar
Keyword(s):  
Acute Exacerbation ◽  
Serum Magnesium ◽  
Acute Exacerbation Of Copd ◽  
Exacerbation Of Copd
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