Frequency of gall bladder carcinoma in cholecystectomies for symptomatic cholelithiasis

2020 ◽  
pp. 1-4
Author(s):  
Muhammad Amar Qudeer ◽  
Syed Asghar Naqi ◽  
Muhammad Zeeshan Sarwar ◽  
Hafiza Amina Mujahid ◽  
Admin
Keyword(s):  
Survival Rate ◽  
Gall Bladder ◽  
Gall Bladder Carcinoma ◽  
Stone Size ◽  
Gastrointestinal Malignancies ◽  
Gallbladder Polyps ◽  
Symptomatic Cholelithiasis ◽  
Carcinoma Gall Bladder ◽  
Gall Stones ◽  
Carcinoma Gallbladder

It was a Letter to the Editor to find out the frequency of carcinoma gall bladder in patients which were presented with symptomatic cholelithiasis. Carcinoma of the gallbladder is a rear malignancy with 5 year survival rate of 5%. Carcinoma gall bladder is the most common billiary tract malignancy, it is also 5th most common in gastrointestinal malignancies 1. In Pakistan the incidence of carcinoma gallbladder among patients having symptomatic cholelithiasis is 6 to 28%2. Patients with symptomatic gall stones had more risk for developing carcinoma gallbladder as compared to asymptomatic gall stones. Large stones in cholelithiasis are more dangerous than small stones as stone size reaches >3cm risk increases upto 10 fold. Gallbladder polyps >10mm, calcified(porcelain) gallbladder, choledochal cyst, seclerosing cholangitis, anomalous pancreaticobillary junctions and exposure to carcinogens are other risk factors3. Continuous...

scholarly journals MUCINOUS ADENOCARCINOMA OF GALL BLADDER: A RARE ENTITY IN GALL BALDDER ADENOCARCINOMA

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Sushil Kumar Shukla ◽  
Rohini Garg ◽  
Dushyant Gaur ◽  
Anshika Arora ◽  
Anuradha Kusum
Keyword(s):  
Gall Bladder ◽  
Mucinous Adenocarcinoma ◽  
Mucinous Carcinoma ◽  
Rare Entity ◽  
Gall Bladder Carcinoma ◽  
Mucinous Component ◽  
Carcinoma Gall Bladder ◽  
Signet Ring ◽  
Bladder Adenocarcinoma ◽  
Histopathological Subtype

Gall bladder carcinoma is the most common type of tumor of the biliary tract and adenocarcinoma is the major histopathological subtype. Mucinous variant is a rare subtype and mucinous carcinoma accompanied with signet ring is extremely rare. When mucinous component exceeds 90% of the tumor, it is labeled as pure mucinous carcinoma. Immunohistochemistry helps to distinguish primary mucinous adenocarcinoma of gall bladder from pseudo myxoma peritonei from appendiceal neoplasm. Mucinous carcinoma is CK 7 positive and CK20 negative. We report a case of mucinous adenocarcinoma arising from the fundus of the gall bladder. Keywords: Mucinous carcinoma, Gall bladder, Adenocarcinoma, Metastatic deposits

Clinicopathological study of gall bladder carcinoma: Our experience from Patan Hospital, Patan Academy of Health Sciences

2019 ◽  
Vol 22 (2) ◽  
pp. 4-10
Author(s):  
Sanjaya Paudyal ◽  
Shiva Raj K.C. ◽  
Shanta Bir Maharjan ◽  
Surendra Shah ◽  
Niraj Giri
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Advanced Disease ◽  
Radical Surgery ◽  
Curative Treatment ◽  
Common Disease ◽  
Radical Excision ◽  
Gall Bladder Carcinoma ◽  
Surgical Department ◽  
Carcinoma Gall Bladder

Introduction: Gall bladder carcinoma is not a common disease. The overall prevalence is low worldwide. It is a highly malignant tumor with a poor prognosis. The outcome of gallbladder carcinoma is poor, and the overall 5-year survival rate is less than 5%. The carcinoma gall bladder is 2-6 times more common in females compared to males and its incidence increases with increasing age. Aggressive surgical management and preoperative adjuvant therapy have helped to prolong survival in patients with gallbladder cancer. We conducted a study with an aim to evaluate the clinicopathological aspect of the disease in patients of gall bladder cancer managed in our surgical department. Methods: Data were recorded retrospectively by reviewing the charts of the patients who were diagnosed and treated for carcinoma gall bladder in Patan hospital from Aug 2017 to Aug 2019. Results: Thirty patients were included in the study. Twenty (66.7%) were female and ten (33.33%) were males. Age ranged from 36 to 83 years with the median age of presentation at 63.5 yrs. Curative treatment was possible in 43.33% of the patients, among them 12 had radical surgery and one had cholecystectomy alone for the T1a stage.  All other (56.6%) required palliative treatment. One patient developed liver metastasis within six months of radical excision. Conclusions: The majority of the patients present with an advanced disease which makes it less chance for curative surgical resection. Since only palliative care is possible in an advanced stage, early detection and curative treatment are advisable.

scholarly journals Role of Tumour Markers Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, & Alpha Fetoprotein in Carcinoma Gall Bladder

2021 ◽  
Vol 10 (10) ◽  
pp. 719-723
Author(s):  
Saurabh Rai ◽  
Chandra Shekhar ◽  
Osman Musa ◽  
Nisar Ansari ◽  
Rahul Agrawal ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Carcinoembryonic Antigen ◽  
Bladder Carcinoma ◽  
Carbohydrate Antigen ◽  
Tumour Markers ◽  
Alpha Fetoprotein ◽  
Advanced Stage ◽  
Gall Bladder Carcinoma ◽  
Carcinoma Gall Bladder

BACKGROUND Gallbladder cancer is recognised as an irreversible malignancy with a high fatality rate. The highest incidence of gall bladder carcinoma is seen in India and Chile, and relatively low level in many Western countries. Gall bladder carcinoma has an extremely poor prognosis, increasing incidence, and diagnosed at an advanced stage despite recent advances in diagnostic modalities. Considering the high rate of mortality attributable mainly to late detection of disease at an advanced stage, early diagnosis remains to be one of the most important determinants of the outcome. This study was conducted to assess the role of tumour markers, namely carbohydrate antigen (CA 19-9), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in the diagnosis of gall bladder carcinoma. We wanted to assess the diagnostic role of tumour markers in carcinoma gall bladder. METHODS Patients with radiologically and histopathologically confirmed diagnosis of carcinoma gall bladder were invited to participate in the study. A thorough history was taken, and relevant examination done as per protocol. All necessary laboratory and radiologic investigations were done according to study design. Assessment of the tumour markers CA19-9, CEA and AFP was done, and values compared with carcinoma gall bladder patients. RESULTS The diagnostic value of tumour markers has been studied in context with histopathological grade as all the cases were histopathologically proven cases of carcinoma gall bladder (Ca GB). CONCLUSIONS The present study showed that CA 19-9 was most effective with regard to its ability to differentiate between different grades of gall bladder carcinoma. KEY WORDS CA 19-9, CEA, AFP, Carcinoma Gallbladder

scholarly journals Mucinous Carcinoma of Gall Bladder – A Rare Case Report

2021 ◽  
Vol 11 (6) ◽  
pp. 326-328
Author(s):  
Nanda Patil ◽  
Vaidehi Nagar
Keyword(s):  
Case Report ◽  
Gall Bladder ◽  
Histopathological Examination ◽  
Mucinous Carcinoma ◽  
Tumour Volume ◽  
Definitive Diagnosis ◽  
Gall Bladder Carcinoma ◽  
Rare Type ◽  
Carcinoma Gall Bladder ◽  
Rare Case Report

Background: Mucinous carcinoma of the gall bladder is a very rare type of gall bladder carcinoma. It is characterized by production of extracellular mucin >50% of tumour volume. Case Report: We report a case of primary mucinous carcinoma of gall bladder in a 60-year-old female patient who was diagnosed clinically as acute cholecystitis. Histopathological examination gave the definitive diagnosis in this case. Conclusion: Mucinous carcinoma of gall bladder exhibit significant clinicopathological difference from conventional adenocarcinoma of gall bladder and display aggressive clinical behaviour. Key words: Mucinous Carcinoma, Gall Bladder, Primary.

Gallbladder polyp

2018 ◽  
Vol 1 (1) ◽  
pp. 23-24
Author(s):  
Watcharasak Chotiyaputta
Keyword(s):  
Gall Bladder ◽  
Gallbladder Polyp ◽  
Gallbladder Polyps ◽  
Upper Abdomen ◽  
Bladder Polyp

Gall bladder polyp เป็นภาวะที่พบได้บ่อย คาดว่าพบได้ประมาณร้อยละ 5 ของประชากรทั่วไป การวินิจฉัยที่สำคัญคือการตรวจด้วยอัลตร้าซาวนด์บริเวณถุงน้ำดีซึ่งต้องแยกให้ดีระหว่าง gall bladder polyp และ gallstone การรักษาที่สำคัญคือการผ่าตัดถุงน้ำดีออกเมื่อติ่งเนื้อมีขนาดเกิน 1 ซม ถ้าขนาดไม่เกินควรทำการติดตามดุว่าติ่งเนื้อมีขนาดใหญ่ขึ้นหรือไม่ โดยเฉพาะในช่วง 2 ปีแรก Figure 4 CT of upper abdomen แสดง multiple gallbladder polyps และ gallstones โดยลักษณะของ gallstones เป็น densed hyperdensity มากกว่า gallbladder polyps

Krukenberg tumor secondary to gall bladder carcinoma masquerading C3 glomerulopathy

2020 ◽  
Vol 4 (3) ◽  
pp. 105-108
Author(s):  
Priti Meena ◽  
Vinant Bhargava ◽  
Devinder Singh Rana ◽  
Anil Kumar Bhalla ◽  
Ashwani Gupta ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Case Reports ◽  
Abdominal Distension ◽  
Gastrointestinal Neoplasms ◽  
Solid Organ ◽  
Krukenberg Tumor ◽  
C3 Glomerulopathy ◽  
Gall Bladder Carcinoma ◽  
Loss Of Appetite

Background: C3 glomerulopathy is caused by dysregulation of the alternative complement pathway. Association with solid organ tumors is rare. However, there have been a few case reports of membranoproliferative glomerulonephritis secondary to gastrointestinal neoplasms. Case: A 38-year-old female presented with abdominal distension, loss of appetite, amenorrhea, and easy fatigability. She had been diagnosed 8 months back with C3 glomerulopathy and had received immunosuppression. On evaluation, she was incidentally detected to have Krukenberg tumor. The primary site of malignancy was gall bladder. Conclusion: Our case report highlights a possible association between C3 glomerulopathy and Krukenberg tumor secondary to gall bladder carcinoma and emphasizes the fact that even in cases of C3 glomerulopathy, occult malignancy should be considered as an underlying pathology.

INCIDENTAL GALL BLADDER CARCINOMA (IGBC) IN CHOLECYSTECTOMY SPECIMENS REMOVED FOR CHOLELITHIASIS

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Dharmpal Godara ◽  
Vijay Pal Singh Dhayal
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Survival Outcome ◽  
Sectional Study ◽  
Gall Bladder Carcinoma ◽  
Cross Sectional ◽  
Hospital Records

Background: The present study highlights the occurrence of Incidental gallbladder carcinoma (IGBC) detected during histopathological examination in cholecystectomy specimens removed for cholelithiasis. Methods- This is a tertiary hospital based cross-sectional study of 500 cholecystectomy specimens removed during cholelithiasis. Relevant hospital records, histopathology slides and reports were reviewed, re-evaluated and studied. Results: 4(0.80%) cases of incidental gall bladder carcinoma (IGBC) were diagnosed from the histopathological evaluation (HPE) of 500 cholecystectomy specimens, constituting 0.80% of gall bladder specimens received during the study period. The age of the patients with IGBC ranged from 51-80 years. More females were affected than males with a M:F ratio of 1:3. Conclusion: Early detection of IGBC by histopathological examination would have a favourable impact on prognosis and management thereby increasing the survival outcome. Keywords: Cholelithiasis, Incidental Gall Bladder Carcinoma

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