scholarly journals TOMOGRAFÍA DE COHERENCIA ÓPTICA COMO MARCADOR PARA LAS ENFERMEDADES NEURODEGENERATIVAS DE ALZHEIMER Y PARKINSON.

2021 ◽  
Vol 32 (1) ◽  
Author(s):  
Victoria Coba ◽  
Cristina Paredes ◽  
Jorge Rivera
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Review Literature ◽  
Observational Research ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Ancillary Test ◽  
Potential Biomarker

Background: Optical coherence tomography (OCT) is an ancillary test used in retinal pathology. The objective of the present dissertation is to review literature regarding (OCT) and its importance as a biomarker in neurodegenerative Alzheimer’s and Parkinson’s disease, through an analysis of medical journal articles published between 2015 and 2019. Methods: A retrospective systematic review without meta-analysis of literature was carried out using observational research design, allowing to summarize the results of multiple primary investigations. Ten studies published between 2015 and 2019 regarding the application of OCT and ANGIO OCT in adult patients older than 60 years of age with preclinical Alzheimer’s disease (AD) or Parkinson’s disease (PD) with retinal microvascular abnormalities, were selected. Results: Areas of increased thickness of ganglion cell-inner plexiform layer (GCIPL) and nerve fiber layer (NFL) adyacent to the macula suggest that dynamic changes can occur as a result of AD progression. Thinning of the retina is present during early stages of PD. This correlates with disease severity and may be related to degeneration of dopaminergic neurons in the substantia nigra. Conclusion: Optical Coherence Tomography is a potential biomarker for AD and PD, and if these pathologies are suspected early, and if these pathologies are suspected early, it could be requested as diagnostic support.

A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography

2015 ◽  
Vol 30 (12) ◽  
pp. 1692-1695 ◽  
Author(s):  
Samantha Slotnick ◽  
Yin Ding ◽  
Sofya Glazman ◽  
Mary Durbin ◽  
Shahnaz Miri ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Optical Coherence

scholarly journals Scanning laser polarimetry and spectral domain optical coherence tomography for the detection of retinal changes in Parkinson's disease

2015 ◽  
Vol 93 (8) ◽  
pp. e672-e677 ◽  
Author(s):  
Birthe Stemplewitz ◽  
Matthias Keserü ◽  
Diana Bittersohl ◽  
Carsten Buhmann ◽  
Christos Skevas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Scanning Laser ◽  
Optical Coherence ◽  
Scanning Laser Polarimetry ◽  
Laser Polarimetry

scholarly journals Peripapillary microvasculature in patients with diabetes mellitus: An optical coherence tomography angiography study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yong-Il Shin ◽  
Ki Yup Nam ◽  
Seong Eun Lee ◽  
Min-Woo Lee ◽  
Hyung-Bin Lim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Plexiform Layer ◽  
Control Group ◽  
Diabetic Patients ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Regression Analyses ◽  
Fiber Layer

Abstract To evaluate changes in peripapillary microvascular parameters in diabetes mellitus (DM) patients using optical coherence tomography angiography (OCTA). Seventy-one diabetic patients (40 in the no diabetic retinopathy [DR] group and 31 in the non-proliferative DR [NPDR] group) and 50 control subjects. OCTA (Zeiss HD-OCT 5000 with AngioPlex) 6 × 6 mm scans centered on the optic disc were analyzed. Peripapillary vessel density (VD), perfusion density (PD) in superficial capillary plexus (SCP) were automatically calculated. The average macular ganglion cell-inner plexiform layer (mGC-IPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses of the no DR and NPDR groups were significantly thinner than those of the control group. The no DR and NPDR groups showed lower peripapillary VD and PD in SCP compared with the control group. Using univariate regression analyses, the average mGC-IPL thickness, the pRNFL thickness, the no DR group and NPDR group were significant factors that affected the peripapillary VD and PD in SCP. Multivariate regression analyses showed that the grade of DR was a significant factor affecting the peripapillary VD and PD in SCP. OCTA revealed that peripapillary microvascular parameters in the no DR and NPDR groups were lower than those of normal controls. The peripapillary VD and PD in SCP were correlated with the mGC-IPL thickness, the pRNFL thickness, and the no DR and NPDR groups. Changes in peripapillary OCTA parameters may help with understanding the pathophysiology of DM and evaluating a potentially valuable biomarker for patients with subclinical DR.

scholarly journals Outer Retinal Assessment Using Spectral-Domain Optical Coherence Tomography in Patients With Alzheimer's and Parkinson's Disease

2018 ◽  
Vol 59 (7) ◽  
pp. 2768 ◽  
Author(s):  
Atsuro Uchida ◽  
Jagan A. Pillai ◽  
Robert Bermel ◽  
Aaron Bonner-Jackson ◽  
Alexander Rae-Grant ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Optical Coherence

scholarly journals Optical coherence tomography findings in Parkinson's disease

2018 ◽  
Vol 34 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Turkoglu Sule Aydin ◽  
Dogan Umit ◽  
Ogun Muhammed Nur ◽  
Ulas Fatih ◽  
Keles Asena ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Optical Coherence

scholarly journals Visual Impairments Are Associated With Retinal Microvascular Density in Patients With Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Min Zhou ◽  
Lei Wu ◽  
Qinyuan Hu ◽  
Congyao Wang ◽  
Jiacheng Ye ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Impairment ◽  
Characteristic Curve ◽  
Microvascular Density ◽  
Inner Plexiform Layer ◽  
Healthy Controls ◽  
Fiber Layer ◽  
P100 Latency ◽  
Retinal Microvasculature

ObjectiveThis study aimed to evaluate retinal microvascular density in patients with Parkinson’s disease (PD) and its correlation with visual impairment.MethodsThis cross-sectional study included 24 eyes of 24 patients with PD and 23 eyes of 23 healthy controls. All participants underwent ophthalmic examination, visual evoked potential (VEP) test, 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), and optical coherence tomography angiography (OCTA) examination. The correlation between retinal microvascular density and visual parameter was evaluated using Spearman correlation analysis, and the area under receiver operating characteristic curve (AUROC) was calculated.ResultsParkinson’s disease patients had prolonged P100 latency (P = 0.041), worse vision-related quality of life (composite score and 3 of 12 subscales in NEI VFQ-25), and decreased vessel density (VD) in all sectors of 3-mm-diameter region (all P < 0.05) compared with healthy controls. There were no statistical differences in the ganglion cell-inner plexiform layer (GCIPL) thickness and retinal nerve fiber layer (RNFL) thickness between the two groups. A negative correlation was found between P100 latency and nasal and superior sectors of macular VD in a 3-mm-diameter region (r = −0.328, P = 0.030; r = −0.302, and P = 0.047, respectively). Macular VD in a 3-mm-diameter region showed diagnostic capacities to distinguish PD patients from healthy controls (AUROCs, ranging from 0.655 to 0.723).ConclusionThis study demonstrated that decreased retinal microvascular density was correlated with visual impairment in PD patients. Retinal microvasculature change may occur earlier than visual decline and retinal structure change and has the potential to be a promising diagnostic marker for early PD.

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