A Rare Case of Sinonasal Extramedullary Plasmacytoma with Orbital Involvement

ABSTRACT Extramedullary plasmacytoma (EMP) is a rare entity in the head and neck region. It is phenotypically and immunologically different from multiple myeloma. Chronic transformation to multiple myeloma or its disseminated form is well known. It may even be the first manifestation of multiple myeloma also popularly known as secondary EMP. We present a 43-year-old male patient with history of persistent progressive nasal obstruction with occasional epistaxis. Endoscopy revealed a right sinonasal mass which on excision biopsy was consistent with features of EMP. Extramedullary plasmacytoma is a rare differential diagnosis for sinonasal mass. However, multiple myeloma should be ruled out via bone marrow examination, bone scan and serum and urine electrophoretic evaluation before arising at a diagnosis of EMP. In spite of EMP of nasal cavity being a rare entity, it should be considered as one of the rare differential diagnoses. How to cite this article Ashish G, Chandrasekharan R, Parmar H. A Rare Case of Sinonasal Extramedullary Plasmacytoma with Orbital Involvement. Int J Head Neck Surg 2015; 6(3):121-124.

Download Full-text

Pulsatile Midline Solitary Plasmacytoma in the Frontal Head Region-A Case Report”

Bangladesh Journal of Neuroscience ◽

10.3329/bjn.v32i1.57412 ◽

2016 ◽

Vol 32 (1) ◽

pp. 39-42

Author(s):

Md Atikur Rahman ◽

Aklaque Hossain Khan ◽

Kanak Kanti Barua

Keyword(s):

Multiple Myeloma ◽

Differential Diagnosis ◽

Case Report ◽

Histological Examination ◽

Plasma Cells ◽

Extramedullary Plasmacytoma ◽

Solitary Plasmacytoma ◽

Rare Entity ◽

Head Region ◽

Malignant Plasma Cell

Primary craniocerebral plasmacytomas are uncommon and represent only 0.7 % of all plasmacytomas. In this case solitary plasmacytoma in the midline frontal head region of the skull and discuss the clinical features and prognosis of this tumor. Plasmacytoma can present as multiple myeloma, solitary plasmacytoma of the bone or extramedullary plasmacytoma. Solitary plasmacytoma is a rare entity that composes of malignant plasma cells and involves the bone to form only one or two lesions without evidence of disease dissemination. It accounts for only 4% of malignant plasma cell tumors. 50 years old male was suffering from plasmacytoma in the frontal head region in our case which is pulsatile. On images showed multiple differential diagnosis but after operation histological examination revealed plasmacytoma. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 39-42

Download Full-text

A Rare Case of Extramedullary Relapse of Multiple Myeloma Causing Bowel Obstruction

Case Reports in Hematology ◽

10.1155/2019/4962678 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Prarthna V. Bhardwaj ◽

Shrinkhala Khanna ◽

Majd D. Jawad ◽

Syed S. Ali

Keyword(s):

Multiple Myeloma ◽

Bowel Obstruction ◽

Rare Case ◽

Soft Tissues ◽

Plasma Cells ◽

Case Reports ◽

Rare Entity ◽

Risk Gene ◽

Gene Profiles ◽

Extramedullary Relapse

Extramedullary myeloma, defined by presence of plasma cells outside the bone marrow, is a rare entity accounting for about 3–9% of all cases. It usually is aggressive with a median survival of <6 months. It is also associated with adverse prognostic factors including 17p deletions and high-risk gene profiles. While common extramedullary sites include bones, there have been several case reports of hematogenous extramedullary myeloma to the liver, lungs, pancreas, breast, skin, and soft tissues. Extramedullary myeloma to the mesentery is a rare entity with only a handful of cases reported. We present a case of 69-year-old man presenting with relapse of multiple myeloma to the mesentery, resulting in bowel obstruction to highlight the various presentations of myeloma.

Download Full-text

Rare case of solitary plasmacytoma of the skull in a young male patient

South African Journal of Radiology ◽

10.4102/sajr.v21i1.1133 ◽

2017 ◽

Vol 21 (1) ◽

Author(s):

Swati Singh ◽

Vaishali Upadhyaya ◽

Rajat Agarwal ◽

Ratni B. Gujral

Keyword(s):

Elderly Patient ◽

Multiple Myeloma ◽

Male Patient ◽

Rare Case ◽

Osteolytic Lesion ◽

Young Male ◽

Axial Skeleton ◽

Solitary Plasmacytoma ◽

Age Group ◽

Rare Entity

Solitary plasmacytoma of bone without signs of multiple myeloma is a rare entity. It usually presents as an osteolytic lesion in the axial skeleton of an elderly patient. Here, we report a case of solitary plasmacytoma in the skull of a young male patient which emphasises the need to consider it in the differential diagnosis of a destructive calvarial mass lesion even in this age group.

Download Full-text

Relapse of multiple myeloma presenting as extramedullary plasmacytoma surrounding the aorta: a rare case report

Hematology Transfusion and Cell Therapy ◽

10.1016/j.htct.2020.09.094 ◽

2020 ◽

Vol 42 ◽

pp. 52

Author(s):

O. Ekinci ◽

A. Dogan ◽

M. Aslan ◽

S. Ebinc ◽

C. Demir

Keyword(s):

Multiple Myeloma ◽

Case Report ◽

Rare Case ◽

Extramedullary Plasmacytoma ◽

Rare Case Report

Download Full-text

A rare case of acrochordon of external auditory canal

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20204642 ◽

2020 ◽

Vol 6 (11) ◽

pp. 2119

Author(s):

Chandre Gowda Bendiganahalli Venkate Gowda ◽

Rakshita R. Kamath

Keyword(s):

Differential Diagnosis ◽

External Auditory Canal ◽

Rare Case ◽

Neck Region ◽

Excisional Biopsy ◽

Rare Entity ◽

Head And Neck Region ◽

Polypoidal Growth ◽

The Right ◽

The Masses

<p class="abstract">Independently arising acrochordon of the external auditory canal is a rare entity with only one reported case in literature. We present here the second such case. A 54-yr old lady presented to our outpatient department with complains of aural fullness and reduced hearing in right ear for 2 weeks. Clinical examination showed a pedunculated polypoidal growth in the external auditory canal. Excisional biopsy and histopathology revealed an acrochordon. Following the procedure, patient was free of symptoms and all structures of the right ear were normal. In the head and neck region, acrochordons have only but once been reported in the external auditory canal and hence should be considered as a differential diagnosis in the masses of this region. Resection must be done for confirmation of diagnosis, differentiation from neoplasia and alleviation of symptoms when associated. </p>

Download Full-text

A Rare Case of Extramedullary Plasmacytoma of the Pleura Causing Spinal Cord Compression in a Patient with Multiple Myeloma

Medical Science Case Reports ◽

10.12659/mscr.901989 ◽

2017 ◽

Vol 4 ◽

pp. 19-24

Author(s):

Carmen E. González ◽

Maria T. Cruz-Carreras ◽

Nandita Guha-Thakurta ◽

Ninotchka Brydges ◽

Patrick S. Chaftari

Keyword(s):

Spinal Cord ◽

Multiple Myeloma ◽

Spinal Cord Compression ◽

Rare Case ◽

Cord Compression ◽

Extramedullary Plasmacytoma

Download Full-text

Triple manifestation of extramedullary plasmacytoma in the upper airway: an unusual clinical entity

The Journal of Laryngology & Otology ◽

10.1017/s0022215111001046 ◽

2011 ◽

Vol 125 (9) ◽

pp. 970-972 ◽

Cited By ~ 2

Author(s):

I Morariu ◽

P Burns ◽

P Roche ◽

S Hone

Keyword(s):

Multiple Myeloma ◽

Rare Case ◽

Unusual Case ◽

English Literature ◽

Upper Airway ◽

Extramedullary Plasmacytoma ◽

Review Of The Literature ◽

Close Cooperation ◽

Disease Free ◽

Extramedullary Plasmacytomas

AbstractObjective:We report an extremely rare case of extramedullary plasmacytoma.Method:Case report and review of the English-literature concerning extramedullary plasmacytoma and multiple myeloma.Result:We present an unusual case of multiple extramedullary plasmacytomas, which, over a protracted course of 30 years, presented on different occasions at three separate sites in the head and neck. The patient was managed surgically on all occasions, and was disease-free at the time of writing.Conclusion:Following review of the literature, we believe this to be the only case with this extremely unusual presentation. This case is noteworthy, not only because of the rarity of extramedullary plasmacytoma, but also because it highlights a number of important clinical issues. The diagnosis and management of extramedullary plasmacytoma require close cooperation between multiple disciplines.

Download Full-text

A Rare Nasopharyngeal Presentation of Amyloidosis

Ear Nose & Throat Journal ◽

10.1177/0145561320914432 ◽

2020 ◽

pp. 014556132091443

Author(s):

Erika Crosetti ◽

Andrea Manca ◽

Elena Maldi ◽

Giovanni Succo

Keyword(s):

Multiple Myeloma ◽

Head And Neck ◽

Rare Case ◽

Standard Treatment ◽

Inflammatory Diseases ◽

Systemic Diseases ◽

Rare Entity ◽

Chronic Inflammatory Diseases ◽

Transoral Resection

Amyloidosis is a heterogeneous group of diseases characterized by the extracellular deposition of insoluble proteins whose pathogenesis is not yet fully understood. The deposition of amyloid proteins can be systemic or localized, idiopathic or related to systemic diseases, mostly multiple myeloma or chronic inflammatory diseases. Localized head and neck amyloidosis is a rare entity, mainly involving the larynx. Given the rarity of the disease and the absence of a lasting follow-up protocol, there is no standard treatment defined for localized amyloidosis. We report a rare case of localized nasopharyngeal amyloidosis, treated with complete transoral resection and confirmed by histological examination.

Download Full-text