scholarly journals Pulsatile Midline Solitary Plasmacytoma in the Frontal Head Region-A Case Report”

2016 ◽  
Vol 32 (1) ◽  
pp. 39-42
Author(s):  
Md Atikur Rahman ◽  
Aklaque Hossain Khan ◽  
Kanak Kanti Barua
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Case Report ◽  
Histological Examination ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Rare Entity ◽  
Head Region ◽  
Malignant Plasma Cell

Primary craniocerebral plasmacytomas are uncommon and represent only 0.7 % of all plasmacytomas. In this case solitary plasmacytoma in the midline frontal head region of the skull and discuss the clinical features and prognosis of this tumor. Plasmacytoma can present as multiple myeloma, solitary plasmacytoma of the bone or extramedullary plasmacytoma. Solitary plasmacytoma is a rare entity that composes of malignant plasma cells and involves the bone to form only one or two lesions without evidence of disease dissemination. It accounts for only 4% of malignant plasma cell tumors. 50 years old male was suffering from plasmacytoma in the frontal head region in our case which is pulsatile. On images showed multiple differential diagnosis but after operation histological examination revealed plasmacytoma. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 39-42

scholarly journals PC3 - 216 Presentation of Intradural Extramedullary Plasmacytoma with Intratumoral Hemorrhage: Case Report and Review of Literature

2016 ◽  
Vol 43 (S4) ◽  
pp. S22-S22
Author(s):  
A. Ghare ◽  
F. Haji ◽  
K. MacDougall
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Left Frontal Lobe ◽  
Axial Mass ◽  
Dural Tail ◽  
History Of ◽  
Intradural Extramedullary ◽  
Contrast Ct

Plasmacytomas are solitary tumours characterized by neoplastic proliferation of plasma cells and can be found isolated or in associated with multiple myeloma. Plasmacytomas uncommonly occur intracranially, and dural plasmacytomas without involvement of the calvarium are exceedingly rare. Reported cases indicate durally-based plasmacytomas mimick the appearance of meningioma, lymphoma or sarcoma of the dura. The authors report a case of a 77-year-old male with known multiple myeloma who presented with a 3-week history of confusion, speech impediment, and right sided weakness. A non-contrast CT scan revealed a dense extra-axial mass in the left frontal lobe with initial concerns of an extra-axial hemorrhage. A subsequent MRI demonstrated a contrast enhancing mass with a broad-based dural tail and no underlying calvarial lesion. Differential diagnosis included meningioma or intracranial plasmacytoma. The patient underwent surgical resection and was found to have intratumoural hemorrhage, with pathology confirming plasmacytoma. In the published literature, there are only 20 prior reports of dural plasmacytomas (with and without primary calvarial infiltration), of which only five previous cases reported associated intratumoural hemorrhage. Our case, along with this literature, suggests that new onset of focal neurologic deficits in patients with a history of multiple myeloma merits careful investigation, and that intracranial plasmacytoma should be considered on the differential diagnosis even when imaging reveals masses consistent with hemorrhage or meningioma.

scholarly journals Extramedullary plasmacytoma of the tongue: A case report

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Leart Berdica ◽  
◽  
Teona Bushati ◽  
Alfred Aga ◽  
Emirjona Vajushi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Histopathological Examination ◽  
English Literature ◽  
Extramedullary Plasmacytoma ◽  
Imaging Data ◽  
Plasma Cell Neoplasms ◽  
Extramedullary Plasmocytoma

Background: Tongue extramedullary plasmacytoma is a very rare pathology. Despite rare cases, extramedullary plasmacytoma should be considered as a differential diagnosis in case of a mass in the tongue. A total of 19 cases were reported with EMP in English literature along with the case we will address. It is characterized by a monoclonal neoplastic proliferation of plasma cells in the absence of multiple myeloma (MM). Histopathology and immunohistochemistry are very important for the diagnosis and differential diagnosis. Case presentation: The case we will describe is an 80-year-old lady from Albania who presents with a vegetative lesion in the form of a thick plate on the dorsal part of the tongue with dimensions 6 X 5 X 1.5 cm. A material of 0.5 cm diameter was taken from the lesion for the biopsy. After histopathological examination, immunohistochemical examinations, and after correlations with laboratory, clinical and imaging data, the diagnosis of extramedullary plasmacytoma of the tongue was reached. The patient underwent radiotherapy treatment. Conclusions: EMP is a rare tumor, accounting for 3% of plasma cell neoplasms and <1% of all head and neck tumors. The diagnosis of EMP, in this case, was reached with biopsy, immunohistochemistry, and the correlation with laboratory and imaging data. We will show the importance of biopsy along with immunohistochemistry in the diagnosis and differential diagnosis of extramedullary plasmocytoma of the tongue. Keywords: plasmacytoma; immunohistochemistry; biopsy; plasma cell. Abbreviations: EMP: Extramedullary plasmacytoma; MM: Multiple myeloma; Cm: centimeter

Single Cell RNA-Seq Reveals Clonal Consistency and Differential Malignancy in Extramedullary Plasmacytoma of Multiple Myeloma

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4808-4808
Author(s):  
Shuang Geng ◽  
Jing Wang ◽  
Mingyi Chen ◽  
Wenming Wang ◽  
Yuhong Pang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Single Cell ◽  
Plasma Cell ◽  
Peripheral Blood ◽  
Plasma Cells ◽  
Conflicts Of Interest ◽  
Extramedullary Plasmacytoma ◽  
Rna Seq ◽  
Malignant Plasma Cell

Abstract Extramedullary Plasmacytoma (EMP) is a minor yet devastating metastatic form of Multiple Myeloma (MM), shortening patients' survival from 10 years to 6 months on average. Genetic cause of EMP in MM is yet to be defined. Transcriptome difference between EMP+ patients and EMP- patients is studied here on single cell level by RNA Sequencing (RNA-Seq). We sorted CD38+CD138+ malignant plasma cells from bone marrow and peripheral blood samples by flow cytometry, then picked up single malignant plasma cell and performed single cell RNA-Seq with SmartSeq2 protocol followed by Tn5-based library preparation from bone marrow, peripheral blood and extramedullary tissue of EMP patients. From the single cell RNA-Seq results, in bone marrow we found differential gene expression between EMP+ and EMP- samples, such as CTAG2, STMN1 and RRM2. By comparing circulating malignant plasma cells in PBMC and malignant plasma cell from the sample EMP+ patient, we observed metastatic clone in blood with the same VDJ immunoglobulin heavy chain as in bone marrow. Several genes' expression of these metastatic cells are down-regulated than in bone marrow, such as PAGE2, GTSF1, DICER1. These genes may correlate with egress capability of MM cells into peripheral to become circulating plasma cells (cPCs), and EMP eventually. Disclosures No relevant conflicts of interest to declare.

scholarly journals Solitary plasmocytoma of the skull: case report and review of the literature

2016 ◽  
Vol 30 (3) ◽  
pp. 412-418
Author(s):  
Luis Rafael Moscote-Salazar ◽  
Hernando Raphael Alvis-Miranda ◽  
Willem Guillermo Calderon-Miranda ◽  
Zenen Antonio Carmona Meza ◽  
Nidia Escobar Hernandez ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Rare Case ◽  
Plasma Cells ◽  
Age Of Onset ◽  
Reticuloendothelial System ◽  
Solitary Plasmacytoma ◽  
Review Of The Literature ◽  
Long Period ◽  
Extramedullary Plasmocytoma

Abstract Solitary plasmacytoma and extramedullary plasmocytoma are tumors of malignant character composed of plasma cells, with a mean age of onset at 60 years. They can appear anywhere where the reticuloendothelial system is present. Usually these tumors lead to the development of multiple myeloma in a period of time ranging from 3 to 5 years. We present a rare case handled in our neurosurgery service associated with an unusually long period of evolution.

scholarly journals SOLITARY PLASMACYTOMA

2017 ◽  
Vol 9 (1) ◽  
pp. e2017052 ◽  
Author(s):  
Sara Grammatico ◽  
Emilia Scalzulli ◽  
Maria Teresa Petrucci
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cells ◽  
Systemic Disease ◽  
Extramedullary Plasmacytoma ◽  
Bone Lesions ◽  
Solitary Plasmacytoma ◽  
Systemic Involvement ◽  
Number Of Patients ◽  
Solitary Bone Plasmacytoma ◽  
Solitary Extramedullary Plasmacytoma

Solitary plasmacytoma is a rare disease characterized by a localized proliferation of neoplastic monoclonal plasma cells, without evidence of systemic disease. It can be subdivided into solitary bone plasmacytoma, if the lesion originates in bone, or solitary extramedullary plasmacytoma, if the lesion involves a soft tissue. Incidence of solitary bone plasmacytoma is higher than solitary extramedullary plasmacytoma. Also prognosis is different: even if both forms respond well to treatment, overall survival and progression free survival of solitary bone plasmacytoma is poorer than solitary extramedullary plasmacytoma due to its higher rate of evolution in multiple myeloma. However, the recent advances in the diagnosis of multiple myeloma can better refine also the diagnosis of plasmacytoma. Flow cytometry studies and molecular analysis may reveal clonal plasma cells in the bone marrow; magnetic resonance imaging or 18 Fluorodeoxyglucose positron emission tomography could better define osteolytic bone lesions. A more precise exclusion of eventual occult systemic involvement can avoid cases of misdiagnosed multiple myeloma patients, that were previously considered solitary plasmacytoma and less treated, with an unavoidable poor prognosis.Due to the rarity of the disease, there is no uniform consensus about prognostic factors and treatment. Radiotherapy is the treatment of choice; however, some authors debates about the radiotherapy dose and the relationship with the response rate. Moreover, the role of surgery and chemotherapy is still under debate. Nevertheless, we must consider that the majority of studies include a small number of patients and analyze the efficacy of conventional chemotherapy; few cases are reported concerning the efficacy of novel agents.Keywords: solitary plasmacytoma; myeloma; radiotherapy; osteolytic lesions  

scholarly journals Solitary Intracranial Plasmacytoma in an Unusual Location – A Case Report

2019 ◽  
Vol 16 (1) ◽  
pp. 55-57
Author(s):  
Suresh Bishokarma ◽  
Shikher Shrestha ◽  
Kajan Ranabhat ◽  
Rajesh Panth
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Cerebellopontine Angle ◽  
Plasma Cells ◽  
Solitary Plasmacytoma ◽  
Cranial Nerve Involvement ◽  
Rare Form ◽  
Plasma Cell Dyscrasias ◽  
Systemic Manifestations ◽  
Multiple Cranial Nerve

Plasmacytoma is rare form of plasma cell dyscrasias, where there is malignant proliferation  of plasma cells. Solitary plasmacytoma developsin isolation without systemic manifestations of multiple myeloma (MM). We report a case of cerebellopontine angle (CPA) plasma cytoma, which masqueraded as a schwannoma with multiple cranial nerve involvement and review a literature pertaining to the same pathological entity.

scholarly journals Diagnóstico e tratamento do plasmocitoma solitário ósseo em mandíbula / Diagnosis and treatment of solitary bone plasmacytoma in mandible

2020 ◽  
Vol 65 (1) ◽  
pp. 1
Author(s):  
Dayane Mendonça dos Santos ◽  
Claudia Rebecca Costa Cavalcante Silva ◽  
Ney Morgado Vieira Filho ◽  
Luiz Felipe Lins de Sousa Santos ◽  
Valtuir Barbosa Felix
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Clinical Characteristics ◽  
Plasma Cells ◽  
Solitary Plasmacytoma ◽  
Plasma Cell Disorders ◽  
Accurate Treatment ◽  
Solitary Bone Plasmacytoma ◽  
The Right

Introdução: O plasmocitoma solitário pertence a um conjunto de desordens de células plasmáticas. É representado por uma massa lítica que pode ser encontrada nos ossos, sendo classificado como plasmocitoma solitário ósseo. O seu diagnóstico precoce é fundamental de modo a prevenir a progressão da doença para mieloma múltiplo. Relato de caso: Paciente do sexo feminino, de raça branca, com 81 anos, diagnosticada com plasmocitoma solitário ósseo em mandíbula à direita e tratada com radioterapia de 45Gy. Resultados: Dois anos após a conclusão do tratamento, a paciente continua em acompanhamento odontológico e hematológico, não demonstrando a evidência de transformação para mieloma múltiplo. Conclusão: Devido as características clínicas inespecíficas do plasmocitoma solitário ósseo, a correta utilização dos recursos atuais disponíveis para investigação da lesão possibilita um diagnóstico diferencial, assim como um acurado tratamento e uma proservação contínua da doença.Palavras Chave: Plasmócitos, Mandíbula, Mieloma múltiploABSTRACTIntroduction: Solitary plasmacytoma belongs to a set of plasma cell disorders. It is represented by a lytic mass that can be found in the bones, being classified as solitary bone plasmacytoma. Its precocious diagnosis is essential in order to prevent the progression of the disease for multiple myeloma. Case report: Female patient, Caucasian, 81 years old, diagnosed with solitary bone plasmacytoma in the right mandible and treated with 45Gy radiotherapy. Results: Two years after completion of treatment, the patient continues in dental and hematological follow-up, showing no evidence of transformation for multiple myeloma. Conclusion: Due the not specific clinical characteristics of solitary bone plasmacytoma, the correct use of available resources for investigation of injuries enables for a differential diagnosis, as well as an accurate treatment and a continuous disease preservation.Keywords: Plasma cells, Mandible, Multiple myeloma

scholarly journals Huge Sellar Plasmacytoma as Differential Diagnosis of Invasive Pituitary Adenoma: A Case Report

2021 ◽  
Author(s):  
J. A. Filgueira-Junior ◽  
M. H. Dornelas ◽  
R. Barboza-Filho ◽  
D. B. Basílio ◽  
R. J. B. Valadares ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Visual Acuity ◽  
Differential Diagnosis ◽  
Case Report ◽  
Pituitary Adenoma ◽  
Sphenoid Sinus ◽  
Plasma Cells ◽  
Final Diagnosis ◽  
Osteolytic Lesions ◽  
Extensive Lesion

AbstractSellar plasmacytomas are rare tumors arising from plasma cells. They are often misdiagnosed as adenomas. We report the case of a 63-year-old woman with headache, cranial nerve III palsy and decreased visual acuity. Imaging revealed an extensive lesion centered on the clivus, extending to the cavernous sinus bilaterally and into the sphenoid sinus. The hormonal tests were compatible with panhypopituitarism and mild hyperprolactinemia. The first hypothesis was invasive pituitary adenoma. Partial resection was achieved, and the immunohistochemical evaluation was compatible with plasmacytoma. After a few weeks, she developed lumbar and hip pain, and the imaging confirming osteolytic lesions. The final diagnosis was multiple myeloma.

scholarly journals Retrobulbar secondary plasmacytoma: a case report and systematic review of the literature

2018 ◽  
Vol 5 (9) ◽  
pp. 2703-2707 ◽  
Author(s):  
Mehrdad Payandeh ◽  
Noorodin Karami ◽  
Soode Enayati ◽  
Afshin Karami ◽  
Mehrnoush Aeinfar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Multiple Myeloma ◽  
Case Report ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Therapeutic Options ◽  
Review Of The Literature ◽  
Orbital Involvement ◽  
Therapeutic Measures ◽  
Uncommon Case

Multiple myeloma is described by the proliferation of malignant plasma cells, in which orbital involvement is rare. In this report, we collected all cases with orbital multiple myeloma from 2009 to 2018 and investigated the characteristics such as sex, age, common orbital symptoms, unilateral or bilateral and different therapeutic options. Also, we reported an uncommon case of multiple myeloma that has been developed into plasmacytoma. Our patient had been initially diagnosed with multiple myeloma, but after a few months, the disease had progressed to secondary extramedullary plasmacytoma in the retrobulbar. Therapeutic measures, such as surgery to prevent its development in the patient's eye, were successful.

scholarly journals Oral manifestation of multiple myeloma: a case report

2021 ◽  
Author(s):  
Jefferson da Rocha Tenório ◽  
Basílio de Almeida Milani ◽  
Bruno Fernandes Matuck
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Plasma Cells ◽  
Dental Service ◽  
Extramedullary Plasmacytoma ◽  
Histopathological Analysis ◽  
Oral Manifestations ◽  
Incisional Biopsy ◽  
Maxillofacial Region ◽  
Oral Manifestation

Multiple myeloma (MM) is a relatively uncommon oncohematological condition characterized by abnormal proliferation of plasma cells. Oral manifestations of MM can occur in soft and intraosseous parts. We present a case of a 69-year-old man diagnosed with MM and undergoing chemotherapy, referred to the dental service complaining of a nodular swelling in the maxilla. An incisional biopsy was conducted and the histopathological analysis showed a monoclonal proliferation of plasma cells with a positive CD 138 immunophenotype, which allowed the diagnosis of extramedullary plasmacytoma. The outcome of the case was unfavorable and the patient died. We emphasize the importance of diagnosing MM extramedullary disease in the maxillofacial region.

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