Outcome in Periprosthetic Joint Infection Treatment

Author(s):  
Claudio Diaz-Ledezma ◽  
Erik Hansen ◽  
Joel Durinka
2021 ◽  
Author(s):  
Vasiliy N. Leonenko ◽  
Yulia E. Kaliberda ◽  
Vasiliy A. Artyuk

In this paper, we present a framework, which aims at facilitating the choice of the best strategy related to the treatment of periprosthetic joint infection (PJI). The framework includes two models: a detailed non-Markovian model based on the decision tree approach, and a general Markov model, which captures the most essential states of a patient under treatment. The application of the framework is demonstrated on the dataset provided by Russian Scientific Research Institute of Traumatology and Orthopedics “R.R. Vreden”, which contains records of patients with PJI occurred after total hip arthroplasty. The methods of cost-effectiveness analysis of treatment strategies and forecasting of individual treatment outcomes depending on the selected strategy are discussed.


2016 ◽  
Vol 26 (1) ◽  
pp. 20-33 ◽  
Author(s):  
Roland Becker ◽  
Martin Clauss ◽  
Niccolo Rotigliano ◽  
Michael Tobias Hirschmann

2019 ◽  
Vol 2019 ◽  
pp. 1-2
Author(s):  
Bernd Fink ◽  
Konstantinos Anagnostakos ◽  
Heinz Winkler

2019 ◽  
Vol 40 (1_suppl) ◽  
pp. 3S-4S
Author(s):  
Ilker Uçkay ◽  
Christopher B. Hirose ◽  
Mathieu Assal

Recommendation: Every intra-articular injection of the ankle is an invasive procedure associated with potential healthcare-associated infections, including periprosthetic joint infection (PJI) following total ankle arthroplasty (TAA). Based on the limited current literature, the ideal timing for elective TAA after corticosteroid injection for the symptomatic native ankle joint is unknown. The consensus workgroup recommends that at least 3 months pass after corticosteroid injection and prior to performing TAA. Level of Evidence: Limited. Delegate Vote: Agree: 92%, Disagree: 8%, Abstain: 0% (Super Majority, Strong Consensus)


Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 434
Author(s):  
Frank Sebastian Fröschen ◽  
Sophia Schell ◽  
Matthias Dominik Wimmer ◽  
Gunnar Thorben Rembert Hischebeth ◽  
Hendrik Kohlhof ◽  
...  

The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by measuring the individual synovial fluid levels of complement factors (C1q, C3b/iC3b, C4b, C5, C5a, C9, factor B, factor D, factor H, factor I, properdin, and mannose-binding lectin [MBL]). The patients (n = 74) were classified into septic (n = 28) and aseptic (n = 46). Receiver-operator characteristic curves and a multiple regression model to determine the feasibility of a combination of the tested cytokines to determine the infection status were calculated. The synovial fluid levels of C1q, C3b/C3i, C4b, C5, C5a, MBL, and properdin were significantly elevated in the PJI group. The best sensitivity and specificity was found for C1q. The multiple regression models revealed that the combination of C1q, C3b/C3i, C4b, C5, C5a, and MBL was associated with the best sensitivity (83.3%) and specificity (79.2%) for a cutoff value of 0.62 (likelihood ratio: 4.0; area under the curve: 0.853). Nevertheless, only a combined model showed acceptable results. The expression patterns of the complement factors suggested that PJI activates all three pathways of the complement system.


2021 ◽  
pp. 231-249
Author(s):  
Yvonne Achermann ◽  
Michael C. Glanzmann ◽  
Christoph Spormann

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