Some Cases of Giant-cell Tumors and Bone Tumors mistaken for Giant-cell Tumor by X-ray Appearance

We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier. Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts. Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and talar involvement is rare. Despite this rarity, the radiographic appearance and clinical signs of talar lesions should be considered in the differential diagnosis of nontraumatic conditions in the foot. (J Am Podiatr Med Assoc 97(3): 225–228, 2007)

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Intramuscular Tenosynovial Giant Cell Tumor Harboring a Novel CSF1-CD96 Fusion Transcript

International Journal of Surgical Pathology ◽

10.1177/10668969211049833 ◽

2021 ◽

pp. 106689692110498

Author(s):

Haider Mejbel ◽

Gene P. Siegal ◽

Shi Wei

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Gene Rearrangement ◽

Fusion Transcript ◽

Cell Tumor ◽

Molecular Profile ◽

Small Subset ◽

Fusion Partner ◽

Giant Cell Tumors ◽

Tenosynovial Giant Cell Tumor

Tenosynovial giant cell tumors typically arise in the synovium of joints, bursae, or tendon sheaths. They may occur in an intra- or extra-articular location and can be divided into localized and diffuse types. The neoplastic nature of the lesion has been supported by a recurrent CSF1 gene rearrangement in a small subset of lesional cells, of which the most common fusion partner is COL6A3. Herein, we report a case of intramuscular localized tenosynovial giant cell tumor harboring a novel CSF1-CD96 fusion transcript, thus expanding the molecular profile of this tumor.

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Correlation between Campanacci’s radiological classification of giant cell tumor of bone and expression of Cyclin D1 and PCNA

Journal of Solid Tumors ◽

10.5430/jst.v7n1p47 ◽

2017 ◽

Vol 7 (1) ◽

pp. 47

Author(s):

Eréndira G. Estrada-Villaseñor ◽

Hidalgo Bravo Alberto ◽

C. Bandala ◽

P. De la Garza-Montano ◽

Reyes Medina Naxieli ◽

...

Keyword(s):

Cyclin D1 ◽

Giant Cell Tumor ◽

Giant Cell ◽

Descriptive Study ◽

Cell Tumor ◽

Giant Cell Tumors ◽

Radiological Classification ◽

Tumors Of Bone ◽

Made In

Giant cell tumor of bone is considered by his behavior a benign but aggressive neoplasm. The objective of our study was to determine if there is a correlation between the Campanacci’s radiological classification of giant cell tumors of bone and the expression by immunohistochemistry of Cyclin D1 and proliferation cell nuclear antibody (PCNA). A retrospective and descriptive study was made. In total, there were 27 cases. All cases showed Cyclin D1 and PCNA positivity. Rho Spearman for Campanacci and Cyclin D1 expression was 0.06 and for Campanacci and PCNA was 0.418. We conclude that there is a positive correlation between PCNA expression in giant cell tumors of Bone and the Campanacci’s radiological classification II and III, butCyclin D1 expression was no related with radiologic features.

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A Case Report of Giant Cell Tumor of Proximal Fibula in Children

Nepalese Journal of Cancer ◽

10.3126/njc.v4i1.31783 ◽

2020 ◽

Vol 4 (1) ◽

pp. 64-67

Author(s):

Sushil Adhikari ◽

Arun Sigdel ◽

Rajesh Kumar Sah ◽

Luna Devkota

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Cell Tumor ◽

Long Bone ◽

Lytic Lesion ◽

Radiographic Appearance ◽

X Ray ◽

Proximal Fibula ◽

Aggressive Tumor

Giant cell tumour (GCT) is histopathologically benign tumor of long bone particularly in distal femur and the proximal tibia. It commonly occurs in adults of age 20-40 years but rare in children. GCT is considered to be locally aggressive tumor and tendency of recurrence is higher even after surgery. The clinical features are nonspecific, the principle symptoms are pain, swelling and limiting adjacent joint movements. Diagnosis is based on the radiographic appearance and histopathological findings .In our case X-ray showed ill defined lytic lesion on proximal fibula with cortical thinning and MRI finding revealed expansile lyticlesion in meta-epiphysis of right fibula 16×16×28mm adjacent to growth plate with fluid level. The sclerotic rim appears hypo intense on T1 & hyper intense on T2. Core needle biopsy showed giant cell tumor on proximal fibula. Considering the risk of recurrence wide local excision was done. Management of GCT of proximal fibula in young patient is critical for preventing recurrence and enhancing functional outcomes by saving adjacent anatomical structure. No evidence of local recurrence and metastasis was found in 24 months of follow up.

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Giant Cell Tumor of the Ethmoid Sinus: An Unusual Cause of Proptosis in a Child

Otolaryngology ◽

10.1177/019459988209000430 ◽

1982 ◽

Vol 90 (4) ◽

pp. 513-515 ◽

Cited By ~ 4

Author(s):

Steven D. Handler ◽

Peter J. Savino ◽

Robert G. Peyster ◽

Norman J. Schatz

Keyword(s):

Head And Neck ◽

Giant Cell Tumor ◽

Giant Cell ◽

Ethmoid Sinus ◽

Cell Tumor ◽

Giant Cell Tumors

Giant cell tumors (osteoclastoma) occur infrequently in the head and neck and are extremely rare in children. The occurrence of such a lesion in the ethmoid sinus of a 14-year-old girl is presented and discussed.

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Recurrence Potential of Diffuse-Type Giant Cell Tumor in the Foot: Radiologic and Pathologic Features

Foot & Ankle International ◽

10.1177/107110070502600608 ◽

2005 ◽

Vol 26 (6) ◽

pp. 474-478 ◽

Cited By ~ 2

Author(s):

Tominaga Shimizu ◽

Takeshi Uehara ◽

Tsutomu Akahane ◽

Kenichi Isobe ◽

Hideki Arai

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Tumor Resection ◽

Cell Tumor ◽

Cell Contact ◽

Diffuse Type ◽

Mri Findings ◽

Giant Cell Tumors ◽

Pathologic Features ◽

Type Giant

Background: Aggressive musculoskeletal tumors in the foot, such as diffuse-type giant cell tumors or extra-abdominal desmoid tumors, are difficult to treat because the foot does not have enough soft tissue to allow wide tumor resection. We reviewed the clinical behavior of diffuse-type giant cell tumor in the foot and evaluated the recurrence potential of these tumors from radiologic and pathologic perspectives. Methods: Six patients with a mean age of 37.6 years were included in this study. Radiologic studies, including sonography, computed tomography (CT), magnetic resonance imaging (MRI), and bone and gallium citrate scintigraphy, were obtained followed by surgical treatment and histologic evaluation of the tumor. Results: Recurrence occurred in three patients. Although CT and MRI findings were similar in the recurrent and nonrecurrent tumors, marked differences were found between the two by scintigraphy; positive radiotracer uptake to the affected foot with gallium citrate scintigraphy was noted only in recurrent tumors, although positive accumulation was seen in all patients with bone scintigraphy. Histologically, the necrotic area and mitotic activity were more apparent in recurrent than in the nonrecurrent tumors, and tumor cell dyscohesion was noted in the former, (the intercellular space was increased). Conclusions: Repeated recurrence with tumor invasion into tarsal bone resulted in breakage of the tarsal arch that supports the body's weight. Amputation would be necessary for patients in whom the disease had progressed to obtain local cure and relief of pain. In the present study, we found two features of the recurrence potential of diffuse-type giant cell tumors: sparse cell to cell contact on pathologic examination and positive accumulation in the tumor on gallium citrate scintigraphy. We concluded that giant cell tumors with these two features have a strong potential for local recurrence, and thus require intensive followup.

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Giant Cell Tumor of the Larynx

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949810700819 ◽

1998 ◽

Vol 107 (8) ◽

pp. 729-732 ◽

Cited By ~ 6

Author(s):

Kenneth O. Devaney ◽

Alfio Ferlito ◽

Alessandra Rinaldo

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Sarcomatoid Carcinoma ◽

Cell Tumor ◽

Long Bone ◽

Giant Cell Tumors ◽

Tentative Diagnosis ◽

True Neoplasm

Among the more uncommon tumors that may sometimes be encountered in the laryngeal region is the recently described giant cell tumor of the larynx. This lesion is a true neoplasm, presumably of the fibrohistiocytic series. Histologically, it closely resembles the more familiar true giant cell tumor of long bone. The laryngeal giant cell tumors appear, to date, to be nonmetastasizing lesions; it is possible that they may recur locally if incompletely excised (although this remains to be demonstrated). In view of the rarity of these tumors, a tentative diagnosis of such a neoplasm should always prompt consideration of other (more frequently encountered) differential diagnostic possibilities, including cytologically malignant giant cell-rich tumors such as malignant fibrous histiocytoma and sarcomatoid carcinoma.

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Dorsal Spine Giant Cell Tumor with paraplegia: A Case Report

Bangladesh Journal of Neuroscience ◽

10.3329/bjn.v31i1.57374 ◽

2015 ◽

Vol 31 (1) ◽

pp. 45-49

Author(s):

Md Atikur Rahman ◽

Mohammad Hossain ◽

ATM Mosharef Hossain

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Osteolytic Lesion ◽

Cell Tumor ◽

Posterior Arch ◽

Thoracic Region ◽

Giant Cell Tumors ◽

Surgical Biopsy ◽

Dorsal Vertebra ◽

Transpedicular Fixation

Patients of Giant cell tumors (GCT) of the spine is rarely seen . We reported a case of GCT of the eleventh dorsal vertebra presented by severe backache with paraplegia in a 30 year old woman. Imaging showed an osteolytic lesion invading the vertebral body, the posterior arch and compression of the spinal cord. Neurological decompression was performed but pain recurred after 2 months. The MRI of spine revealed recurrence of tumor and again surgical decompressions was done along with long segment transpedicular fixation and patient was significantly improved. A surgical biopsy was obtained at the same time to confirm the diagnosis. Giant cell tumor is not so common in thoracic region. We believe that the gross removal of tumor provide good outcome for the patient. Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 45-49

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Ultrastructure of giant cell tumor of the lung

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100128547 ◽

1987 ◽

Vol 45 ◽

pp. 852-853

Author(s):

C.N. Sun

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Lung Tumor ◽

Present Report ◽

White Male ◽

Lower Lobe ◽

Cell Tumor ◽

Giant Cell Tumors ◽

Tissue Samples ◽

Neoplastic Lesion

Multinucleated giant cells resembling osteoblasts seen in giant-cell tumors of bone have been described in the thyroid gland, and pancreas. However, a giant cell tumor of the lung with osteoblast-like cells is rare. The present report will describe ultrastructural aspects and histiogenesis of this type of lung tumor.A 58-year old white male patient was noted by chest x-ray to have a mass in the right lower lobe of the lung. Segmental resection of the superior segment was performed revealing a nodular neoplastic lesion of 3.5 cm in diameter located 4.3 cm from the bronchial resection margin. For EM preparation, the tissue samples were immediately fixed in 4 percent phosphate-buffered glutaraldehyde and postfixed 1 hr with 1 percent osmium tetroxide in phosphate buffer (pH 7.2), dehydrated in ethanol and embedded in Epon 812. The tumor presented a sheet-like growth pattern without evidence of encapsulation.

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The proximal fibular free flap - an ideal material for reconstructing distal radius defect after Giant tumor cell resection. A case report

Tạp chí Nghiên cứu Y học ◽

10.52852/tcncyh.v148i12.786 ◽

2021 ◽

Vol 148 (12) ◽

pp. 96-101

Author(s):

Duong Manh Chien ◽

Hoang Tuan Anh ◽

Nguyen Tran Quang Sang ◽

Phan Van Tan ◽

Nguyen Huu Trong ◽

...

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Distal Radius ◽

Free Flap ◽

Wrist Joint ◽

Cell Tumor ◽

Joint Function ◽

Giant Cell Tumors ◽

Tumor Excision ◽

Fibular Free Flap

Giant cell tumors (GCT) of the distal end of radius are relatively common tumors, representing approximately 5% of all primary bone tumors. It is the third most common location for GCT following distal femur and proximal tibia. In general, treatment includes thorough tumor excision, reconstruction of the defect, and wrist joint rehabilitation. The proximal fibular free flap is an ideal material for distal radius reconstruction after giant cell tumor excision. We present a case of a 57-year-old female, admitted to the hospital due to painful and limited proper wrist movement. Based on X-ray and Magnetic resonance imaging (MRI) images and histopathology findings, the patient was diagnosed with a stage 3 giant cell tumor of the distal radius. The patient underwent a one-step surgery of tumor excision and distal radius reconstruction by a vascularized proximal fibular free flap. 2 years follow-up post-surgery showed that the patient had no pain of the wrist, improved wrist joint function, no sign of recurrence, and good flap vitality and the knee joint remains normal. In conclusion, the surgery was successful with no further prolonged pain, improvement of the wrist joint function and overall improvement of the patient quality of life.

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