Follow-up Studies of Malignant Primary Bone Tumor (Osteosarcoma, Chondrosarcoma, Ewing's sarcoma)

AbstractEwing's sarcoma (EWS) is the second most common primary bone tumor seen in children and adolescents, first being osteosarcoma. Skull lesions are seen in 6 to 9% of cases. The tumor tends to reside most frequently on frontal and parietal bones. In the literature, majority of papers on calvarial EWS present cases with intracranial involvement; extracranial extension is reported in only eight cases. The case that we are presenting in this report is a 23-year-old male patient with multiple infiltrations in femur, costal bones, and calvarium which had been diagnosed radiologically and histopathologically as EWS. The calvarial metastasis had reached a very huge size with dimensions of approximately 7.5 × 7.5 × 9.5 cm and was successfully excised totally. Twelve months of follow-up revealed no recurrence in the surgical site showing that total removal of giant cranial EWS may improve morbidity of these patients.

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Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Frontiers in Oncology ◽

10.3389/fonc.2020.586580 ◽

2020 ◽

Vol 10 ◽

Author(s):

Zhong-Wei Luo ◽

Pan-Pan Liu ◽

Zhen-Xing Wang ◽

Chun-Yuan Chen ◽

Hui Xie

Keyword(s):

Overall Survival ◽

Tumor Microenvironment ◽

Bone Tumor ◽

Immune Cells ◽

Therapeutic Approaches ◽

Immune Microenvironment ◽

Primary Bone Tumor ◽

Promising Strategy ◽

Primary Bone ◽

Malignant Primary Bone Tumor

Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor microenvironment (TME) is closely related to the occurrence and development of tumors, and macrophages are among the most abundant immune cells in the TME. Due to their vital roles in tumor progression, macrophages have gained increasing attention as the new target of tumor immunotherapy. In this review, we present a brief overview of macrophages in the TME and highlight the clinical significance of macrophages and their roles in the initiation and progression of osteosarcoma. Finally, we summarize the therapeutic approaches targeting macrophage, which represent a promising strategy in osteosarcoma therapies.

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Radio-induced Sarcomas in Survivors of Ewing's Sarcoma

Tumori Journal ◽

10.1177/030089168807400508 ◽

1988 ◽

Vol 74 (5) ◽

pp. 543-551 ◽

Cited By ~ 16

Author(s):

Stefano Boriani ◽

Piero Picei ◽

Alessandra Sudanese ◽

Aldo Toni ◽

Antonia Mancini ◽

...

Keyword(s):

Surgical Resection ◽

Bone Tumor ◽

Irradiation Dose ◽

Ewing’S Sarcoma ◽

Ewing's Sarcoma ◽

Local Treatment ◽

Statistical Analyses ◽

Tumor Center ◽

Rizzoli Orthopaedic Institute

Of 255 cases of Ewing's sarcoma recorded at the Bone Tumor Center of the Rizzoli Orthopaedic Institute, 78 patients (irradiated and with a follow-up of longer than 3 years) were considered « at risk » for the development of a second radio-induced sarcoma (RIS). Three of the 78 patients developed an RIS in the irradiated field. Theoretical and statistical analyses were carried out considering different modalities of local treatment. Statistically, the only significant factor was related to the irradiation dose. Surgical resection seems to prevent RIS.

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Tracheal chondrosarcoma and surgical management

Asian Cardiovascular and Thoracic Annals ◽

10.1177/0218492318778484 ◽

2018 ◽

Vol 27 (1) ◽

pp. 52-54 ◽

Cited By ~ 2

Author(s):

Fazal Wahab Khan ◽

Ibrahim Zahid ◽

Sarosh Moeen ◽

Sulaiman Bashir Hasan

Keyword(s):

Surgical Management ◽

Bone Tumor ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Obstructive Apnea ◽

Primary Bone Tumor ◽

Cartilage Cells ◽

Primary Bone

Chondrosarcoma is a cancer of cartilage cells, and despite being a common primary bone tumor, tracheal chondrosarcoma is rare with only 18 cases reported in the literature prior to mid-2016. A 60-year-old gentleman presented with progressively increasing cough, severe stridor, and production of phlegm for approximately 2 years. On admission to our tertiary care hospital, he developed complete obstructive apnea within an hour, and was intubated. A tracheal biopsy was performed, followed by resection. Histopathology confirmed chondrosarcoma of the trachea. The patient tolerated the procedure very well and is currently symptom-free on follow-up, with no signs of recurrence.

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Rare Case of Metastatic Pleomorphic Liposarcoma of Thigh Presenting as Ewing’s Sarcoma

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v19i1.3324 ◽

2021 ◽

Vol 19 (1) ◽

pp. 215-217

Author(s):

Sandip Giri ◽

Anisha Gehani ◽

Sheena Alphones ◽

Divya Midha ◽

Dibash Baral

Keyword(s):

Ewing’S Sarcoma ◽

Distal Femur ◽

Ewing's Sarcoma ◽

Pediatric Population ◽

Plain Radiograph ◽

Radiology Department ◽

Retroperitoneal Mass ◽

Pleomorphic Liposarcoma ◽

Primary Bone Tumor ◽

Primary Bone

Liposarcoma is an uncommon group of tumors in the pediatric population. Of the various known subtypes,pleomorphic liposarcoma is the most infrequent in children.We present the case of a 7-year old child coming to the radiology department for evaluation of a right knee swelling. Plain radiograph and corresponding MRI images showed features of primary bone tumor possibly Ewing’s sarcoma in right distal femur. The child developed right shoulder pain and CT thorax abdomen was done which revealed retroperitoneal mass with hepatic and pulmonary metastases.Subsequent core needle biopsy from the femur confirmed metastatic liposarcoma with pleomorphic features, extremely rare in childhood.The very rare incidence of metastasis that too presenting as a common primary tumor the misdiagnosis of which could result in catastrophic fate. So it’s of prime importance that clinicians should be aware of this entity. Keywords: FISH; liposarcoma; myxiod dedifferentiated liposarcoma; pleomorphic liposarcoma; softsarcoma

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Primary Bone Tumours of the Pelvis in Childhood—Ewing's Sarcoma of the Ilium, Pubis and Ischium. (Report of 30 cases) (Part I)

Australasian Radiology ◽

10.1111/j.1440-1673.1989.tb03312.x ◽

1989 ◽

Vol 33 (4) ◽

pp. 354-360 ◽

Cited By ~ 4

Author(s):

K. KOZLOWSKI ◽

J. CAMPBELL ◽

G. BELUFFI ◽

J.C. HOEFFEL ◽

L. MORRIS ◽

...

Keyword(s):

Ewing’S Sarcoma ◽

Ewing's Sarcoma ◽

Bone Tumours ◽

Primary Bone ◽

Primary Bone Tumours

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Precise single column resection and reconstruction with femoral head plus THR for malignant pelvic tumors

10.29007/nvsk ◽

2018 ◽

Author(s):

Xiaohui Niu ◽

Yongkun Yang ◽

Qing Zhang ◽

Yuan Li ◽

Hairong Xu ◽

...

Keyword(s):

Femoral Head ◽

Ewing’S Sarcoma ◽

Ewing's Sarcoma ◽

Posterior Column ◽

Surgical Margins ◽

Wide Resection ◽

Navigation Group ◽

Single Column ◽

And Function

Background Some malignant pelvic tumor may affect the anterior or posterior column at the acetabula area. The postoperative recurrenceand complication rate are high. Precise resection with safe surgical margin could cure the patients while saving healthier host bone for relative simple reconstruction.Questions/Purposes The purpose of this study is to evaluate the effect of precise single column resection and reconstruction with femoral head plus THR for malignant pelvic tumorswith respect to the (1) surgical safety, (2) oncological outcome and (3) prosthesis survivorship and function.Methods This is a clinical cases study. From 2007 to 2015, 19 patients with primary malignant tumors of the pelvis were enrolled in the study. The diagnosis included 16 cases of chondrosarcoma, 1 case of undifferentiated polymorphic sarcoma, 1 case of Ewing's sarcoma and 1 case of solitary plasmacytoma. All tumors were resected with safe surgical margins, which were proved by the postoperative specimen evaluation. Anterior column was involved in 17 cases and posterior column in 2 cases. Ten of 19 tumors were resected assisted by computer navigation. Femoral heads were used to reconstruct anterior or posterior column defects and fixed by screws; THR was used for the joint reconstruction. Oncologic outcome and function were evaluated by regular follow-up.Results The follow up time was more than 12 months in 14 cases with the average of 58.4 months (median 61, range 13-118) months. Surgical margins contained wide resection in 12 cases and marginal resection in 7 cases. The bony wide resection rate was 90% (9/10) in the navigation group and 77.8% (7/9) in free hand group respectively. One patient with Ewing's sarcoma died 14 months postoperative due to lung metastasis. There was only one case with chondrosarcoma was found recurrence in 61 months postoperatively, who was in the navigation group and having marginal margin resection. There was one prosthesis removed due to prosthesis infection (14 months postoperatively). There were another two patients with minor wound infection. The average MSTS function score was 24.8 (17-29).Conclusions The current treatment method is oncological safe and functional with less complications. The hardware is relatively cost effective and right on the shelf. However, this procedure is highly skill needed.

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