scholarly journals Injury of Partial Colon Obstruction in Colonic Interstitial Cells With/Without Interstitial Cells of Cajal

2020 ◽  
Vol 26 (2) ◽  
pp. 291-293
Author(s):  
Jianlin Lv ◽  
Meng Xia ◽  
Zengzi Zhou ◽  
Zhenbin Hu
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Colon Obstruction ◽  
Cells Of Cajal

Sa1950 Interstitial Cells of Cajal Do Not Mediate Mechanotranscription and Suppression of Motility Function in Partial Colon Obstruction

2012 ◽  
Vol 142 (5) ◽  
pp. S-366
Author(s):  
Chester C. Wu ◽  
You Min Lin ◽  
John H. Winston ◽  
Sushil K. Sarna ◽  
Xuan-Zheng P. Shi
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Colon Obstruction ◽  
Cells Of Cajal

Decreased density of interstitial cells of cajal and malformations of the enteric nervous system in patients with slow transit consitpation and megacolon

2001 ◽  
Vol 120 (5) ◽  
pp. A332-A332
Author(s):  
T WEDEL ◽  
J SPIEGLER ◽  
S SCHRADER ◽  
H VONKOSCHITZKY ◽  
U ROBLICK ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Slow Transit ◽  
Cells Of Cajal

Sodium current in human small intestinal interstitial cells of cajal

2001 ◽  
Vol 120 (5) ◽  
pp. A201-A201 ◽  
Author(s):  
P STREGE ◽  
A RICH ◽  
Y OU ◽  
S GIBBONS ◽  
M SARR ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Sodium Current ◽  
Interstitial Cells ◽  
Small Intestinal ◽  
Cells Of Cajal

Effects of Morphine on Interstitial Cells of Cajal in Rabbit Colon and Small Intestinal Transit: An Experimental Study

2020 ◽  
Vol 20 (3) ◽  
pp. 240-246
Author(s):  
Heng Yang ◽  
Xiao-Ju Jin ◽  
Hong Luo ◽  
Yuan-Hai Li
Keyword(s):  
Protein Expression ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Saline Control ◽  
Morphine Group ◽  
Small Intestinal Transit ◽  
Medium Concentration ◽  
Epidural Puncture ◽  
Mrna And Protein Expression ◽  
Cells Of Cajal

Objective: This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. Methods: Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of morphine group (L group), medium concentration of morphine group (M group), high concentration of morphine group (H group), medium concentration of morphine and naloxone mixed with antagonist group (NM group). Rabbits in these five groups were administered with an epidural puncture tube and dorsal epidural analgesia pump, and were continuously infused for seven days. Fecal characteristics were observed, and the ink propulsion rate was calculated. The expression level of ICC C-kit protein in colon tissues was tested by western blot. Results: The stool characteristics in the L, M and H groups were more severe than those in the NS and NM groups. Furthermore, the intestinal propulsion rate in the L, M and H groups was lower than that in the NS and NM groups. The C-kit mRNA and protein expression in the colon of rabbits were significantly lower in the L, M and H groups, when compared to the NS and NM groups. Conclusions: Naloxone blocked the mRNA and protein expression of C-kit, and improved intestinal motor function.

Is there a Role for Human Pluripotent Stem Cells in Modelling Interstitial Cells of Cajal and Gut Motility Disorders?

2015 ◽  
Vol 10 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Wenbo Meng ◽  
Jerry Zhou ◽  
Ross Elliott ◽  
Patricia Murphy ◽  
Vincent Ho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Human Pluripotent Stem Cells ◽  
Gut Motility ◽  
Motility Disorders ◽  
Cells Of Cajal

Morphology of the canine pyloric sphincter in relation to function

1989 ◽  
Vol 67 (12) ◽  
pp. 1560-1573 ◽  
Author(s):  
E. E. Daniel ◽  
I. Berezin ◽  
H. D. Allescher ◽  
H. Manaka ◽  
V. Posey-Daniel
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Smooth Muscle Cells ◽  
Gap Junctions ◽  
Vasoactive Intestinal Polypeptide ◽  
Interstitial Cells Of Cajal ◽  
Circular Muscle ◽  
Interstitial Cells ◽  
Pyloric Sphincter ◽  
Cells Of Cajal

The ultrastructure and immunocytochemistry of the canine distal pyloric muscle loop, the pyloric sphincter, were studied. Cells in this muscle were connected by gap junctions, fewer than in the antrum or corpus. The sphincter had a dense innervation and a sparse population of interstitial cells of Cajal. Most such cells were of the circular muscle type but a few were of the type in the myenteric plexus. Nerves were sometimes associated with interstitial cell profiles, but most nerves were neither close to nor associated with interstitial cells nor close to smooth muscle cells. Nerve profiles were characterized by an unusually high proportion of varicosities with a majority or a high proportion of large granular vesicles. Many of these were shown to contain material immunoreactive for vasoactive intestinal polypeptide (VIP) and some had substance P (SP) immunoreactive material. All were presumed to be peptidergic. VIP was present in a higher concentration in this muscle than in adjacent antral or duodenal circular muscle. Interstitial cells of Cajal made gap junctions to smooth muscle and to one another and might provide myogenic pacemaking activity for this muscle, but there was no evidence of a close or special relationship between nerves with VIP or SP and these cells. The absence of close relationships between nerves and either interstitial cells or smooth muscle cells leaves unanswered questions about the structural basis for previous observations of discrete excitatory responses or pyloric sphincter to single stimuli or nerves up to one per second. In conclusion, the structural observations suggest that this muscle has special neural and myogenic control systems and that interstitial cells may function to control myogenic activity of this muscle but not to mediate neural signals.Key words: vasoactive intestinal polypeptide, interstitial cells of Cajal, neuropeptides, gap junctions, substance P.

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